Results 91 to 100 of about 19,706 (202)

Attenuation of Visceral and Somatic Nociception by Ghrelin Mimetics

Journal of Experimental Pharmacology, 2020
Ehsan N Mohammadi,1 Tijs Louwies,1 Claudio Pietra,2 S Robert Northrup,3 Beverley Greenwood-Van Meerveld1 1Oklahoma Center for Neuroscience, Department of Physiology, University of Oklahoma Health Science Center, Oklahoma City, OK, USA; 2Helsinn ...
N Mohammadi E, Louwies T, Pietra C, Northrup SR, Greenwood-Van Meerveld B   +4 more
doaj  

P2X3 receptors mediate visceral hypersensitivity during acute chemically-induced colitis and in the post-inflammatory phase via different mechanisms of sensitization.

PLoS ONE, 2015
ObjectivesExperiments using P2X3 knock-out mice or more general P2X receptor antagonists suggest that P2X3 receptors contribute to visceral hypersensitivity.
Annemie Deiteren, Laura van der Linden, Anouk de Wit, Hannah Ceuleers, Roeland Buckinx, Jean-Pierre Timmermans, Tom G Moreels, Paul A Pelckmans, Joris G De Man, Benedicte Y De Winter   +9 more
doaj   +1 more source

Clinical Trial: Effectiveness and Safety of a Novel Anal Insert Device for Treatment of Faecal Incontinence

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 5, Page 603-614, September 2026.
StaySure is a novel anal insert device that safely and effectively treats medically refractory faecal incontinence. Treatment reduced incontinence episodes by 69%, improved quality of life beyond clinically meaningful thresholds, and was well tolerated with no treatment‐related serious adverse events. ABSTRACT Background Treatment options for medically‐
Adil E. Bharucha, Ramesh Lamichhane, Joel G. Fletcher, Nicholas R. Oblizajek, Misha Gautam, Kent R. Bailey, Lawrence A. Szarka   +6 more
wiley   +1 more source

An interorgan neuroimmune circuit promotes visceral hypersensitivity

Abstract Visceral pain disorders such as interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS) often manifest concurrently in the bladder and colon. Yet, the mechanistic basis of such comorbidities and the transmission of neural hypersensitivity across organ systems has remained a mystery.
Brian Kim, Zhen Wang, Xia Meng, Zili Xie, Chia Chun Hor, wenwen zhang, Xu Li, Keaton Song, Kelsey Auyeung, Hisato Iriki, Rintaro Shibuya, Wen Zhang, Jack Major, Lydia Zamidar, Daniel Yassky, Olivia Seker, Joshua Wollam, Christiane Villescaz, Alan Vest, Swetha Sriniva, Michelle Solomon, Rui Chang, Shruti Naik, Masato Kubo, Veena Viswanath, Shawn Xu, Xinzhong Dong, David Artis, Bo Duan, Hongzhen Hu   +29 more
openaire   +2 more sources

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Systemic acquired resistance: an emerging role for jasmonates in local signal biogenesis, translocation and distal signal decoding

New Phytologist, Volume 251, Issue 6, Page 3142-3158, September 2026.
Jasmonate signalling underpins establishment of plant systemic acquired resistance (SAR). Activation of the hypersensitive response (HR) not only contains the pathogen but establishes broad spectrum resistance in unchallenged leaves. The strong burst of reactive oxygen/nitrogen species initiating the HR results in lipid peroxidation (illustrated by ...
Fay Bennett, Erin Stroud, Pradeep Kachroo, Murray Grant   +3 more
wiley   +1 more source

L‐Probe: New Approach for Spike Removal in Raman Hyperspectral Imaging Based on Local Prominence Peak Filtering

Journal of Chemometrics, Volume 40, Issue 8, August 2026.
ABSTRACT Raman hyperspectral imaging is an indispensable analytical technique that can provide simultaneous chemical and spatial information of a sample, enabling a higher comprehension and sampling of the analyzed material. However, a known challenge in processing large hyperspectral Raman datasets is the effective removal of spurious, high‐intensity ...
Leonardo Francisco Rafael Lemes, Victor Klassen de Oliveira, Frederico Luis Felipe Soares   +2 more
wiley   +1 more source

Skin Rash Management Based on Early Elevation in the Eosinophil Proportion Within 3 Months of Initiating Apalutamide for Prostate Cancer

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Skin rash (SR) is a key issue in the long‐term use of apalutamide (APA) in patients with prostate cancer (PCa); however, there is currently no established strategy for the safe management of APA in preventing SR. Aims To investigate the predictive value of early elevation in the proportion of eosinophils (EE) for SR in patients ...
Dai Koguchi, Hideyasu Tsumura, Ken‐ichi Tabata, Takefumi Satoh, Takashi Tachibana, Shuhei Hirano, Masaomi Ikeda, Daisuke Ishii, Kazumasa Matsumoto   +8 more
wiley   +1 more source

An Olfactory Piriform Cortex‐Lateral Hypothalamus Neural Circuit Contributes to Linalool‐Induced Analgesia

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Linalool odor exposure activates a glutamatergic projection from the piriform cortex to the lateral hypothalamus (PiriGlu‐LH), mediating descending inhibitory pain pathways. This demonstrates a novel neural mechanism for olfactory‐induced pain modulation and suggests potential therapeutic implications for pain management.
Yunhe Zhu, Jingping Sun, Shan Wang, Qidong Zhang, Jian Mao, Guobi Chai, Qingzhao Shi, Wu Fan, Jianping Xie   +8 more
wiley   +1 more source

Mental health multimorbidity and physical conditions in children aged 6–17 years in the United States

General Psychiatry, Volume 39, Issue 4, August 2026.
ABSTRACT Background The rising prevalence and early onset of mental health problems among children and adolescents pose a critical public health challenge. Aims This study aimed to identify distinct profiles of mental health multimorbidity, examine their associations with physical conditions and evaluate the dose–response relationships between the ...
Hua He, Feng Li, Guodong Ding, Fei Li
wiley   +1 more source