Results 111 to 120 of about 21,147 (220)

Hypersensitivity to visceral and cutaneous pain in the irritable bowel syndrome

Pain, 2001
Irritable bowel syndrome (IBS) is one of the most common gastrointestinal illnesses and is characterized by altered visceral perception. Previous studies in IBS have failed to demonstrate altered somatic or cutaneous perception. The aims of the study were to determine whether IBS patients have visceral hypersensitivity and cutaneous heat-induced ...
Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Florida, FL, USA ( host institution ), Verne, G.Nicholas ( author ), Robinson, Michael E ( author ), Price, Donald D ( author )   +3 more
openaire   +3 more sources

Survodutide for the Treatment of Obesity Disease in Japanese Participants: Rationale, Design and Baseline Characteristics of the Phase 3 SYNCHRONIZE‐JP Trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6595-6606, August 2026.
ABSTRACT Aims There is an unmet need for effective pharmacotherapy for obesity disease management in Japan. Survodutide is a novel glucagon receptor/glucagon‐like peptide‐1 receptor (GLP‐1R) dual agonist with the potential to induce greater weight reductions than GLP‐1R mono‐agonists. We report the design and baseline participant characteristics of the
Koutaro Yokote, Toshimasa Yamauchi, Yasushi Fukushima, Yoji Takatsuka, Marie Kato, Shijia Yan, Takayoshi Inoue, Luiza Borowska, Martina Brueckmann, Wataru Ogawa, on behalf of the SYNCHRONIZE‐JP Trial Investigators   +10 more
wiley   +1 more source

P2X3 receptors mediate visceral hypersensitivity during acute chemically-induced colitis and in the post-inflammatory phase via different mechanisms of sensitization.

PLoS ONE, 2015
ObjectivesExperiments using P2X3 knock-out mice or more general P2X receptor antagonists suggest that P2X3 receptors contribute to visceral hypersensitivity.
Annemie Deiteren, Laura van der Linden, Anouk de Wit, Hannah Ceuleers, Roeland Buckinx, Jean-Pierre Timmermans, Tom G Moreels, Paul A Pelckmans, Joris G De Man, Benedicte Y De Winter   +9 more
doaj   +1 more source

Functional dyspepsia: The role of visceral hypersensitivity in its pathogenesis

World Journal of Gastroenterology, 2006
Functional, or non-ulcer, dyspepsia (FD) is one of the most common reasons for referral to gastroenterologists. It is associated with significant morbidity and impaired quality of life. Many authorities believe that functional dyspepsia and irritable bowel syndrome represent part of the spectrum of the same disease process.
John, Keohane, Eamonn M M, Quigley
openaire   +2 more sources

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

Attenuation of Visceral and Somatic Nociception by Ghrelin Mimetics

Journal of Experimental Pharmacology, 2020
Ehsan N Mohammadi,1 Tijs Louwies,1 Claudio Pietra,2 S Robert Northrup,3 Beverley Greenwood-Van Meerveld1 1Oklahoma Center for Neuroscience, Department of Physiology, University of Oklahoma Health Science Center, Oklahoma City, OK, USA; 2Helsinn ...
N Mohammadi E, Louwies T, Pietra C, Northrup SR, Greenwood-Van Meerveld B   +4 more
doaj  

An interorgan neuroimmune circuit promotes visceral hypersensitivity

Abstract Visceral pain disorders such as interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS) often manifest concurrently in the bladder and colon. Yet, the mechanistic basis of such comorbidities and the transmission of neural hypersensitivity across organ systems has remained a mystery.
Brian Kim, Zhen Wang, Xia Meng, Zili Xie, Chia Chun Hor, wenwen zhang, Xu Li, Keaton Song, Kelsey Auyeung, Hisato Iriki, Rintaro Shibuya, Wen Zhang, Jack Major, Lydia Zamidar, Daniel Yassky, Olivia Seker, Joshua Wollam, Christiane Villescaz, Alan Vest, Swetha Sriniva, Michelle Solomon, Rui Chang, Shruti Naik, Masato Kubo, Veena Viswanath, Shawn Xu, Xinzhong Dong, David Artis, Bo Duan, Hongzhen Hu   +29 more
openaire   +2 more sources

Caenorhabditis elegans and Drosophila melanogaster as Model Organisms in Biofactor Research

BioFactors, Volume 52, Issue 4, July/August 2026.
This review presents Caenorhabditis elegans and Drosophila melanogaster as powerful and ethically sound invertebrate model organisms that can be used to investigate nutritional science questions relating to biofactors. Such nutritional phenotyping studies can bridge the gap between in vitro studies and in vivo research in mammals.
Kai Lüersen, Thomas Roeder, Gerald Rimbach   +2 more
wiley   +1 more source

Effect of Nutritional Factors on Mental Health Problems in Autism Spectrum Disorder: A Narrative Synthesis of Current Evidence

Brain and Behavior, Volume 16, Issue 7, July 2026.
This narrative synthesis of 21 studies evaluates nutritional interventions for psychiatric comorbidities in ASD. Vitamin D3, omega‐3 fatty acids, and probiotics show preliminary benefits for anxiety and irritability, whereas GFCF diet results remain inconclusive.
Nalan Hakime Nogay, Gulin Ozturk Ozkan
wiley   +1 more source

Diagnostic Accuracy of Tests for Hymenoptera Venom Hypersensitivity: A Systematic Review and Bayesian Meta‐Analysis Protocol

Health Science Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background and Aims Hymenoptera venom hypersensitivity is a potentially life‐threatening condition that may affect up to 7.5% of adults worldwide and can result in systemic allergic reactions ranging from generalized cutaneous symptoms to severe anaphylaxis.
Bharat Kumar, Madalyn Walsh, Amir Abidov, Melissa Swee   +3 more
wiley   +1 more source