Results 111 to 120 of about 184,182 (219)

Piezo1‐mediated unfolded protein response in goblet cells regulates intestinal mucus barrier homeostasis through the Ca2+–IRE1α–XBP1 pathway

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
This study demonstrates that activation of Piezo1 channels in goblet cells by intestinal mechanical stimulation modulates ER calcium homeostasis via calcium ion (Ca2+) flux, which in turn regulates Mucin2 production and synthesis through the IRE1α‐XBP1. Intraperitoneal administration of Yoda1 alleviates mucus barrier impairment in DSS/WAS‐treated mice.
Jiandi Wu, Shaotong Wang, Zhe Wang, Jianhua Fang, Xueyan Li, Qingqing Zhang, Yan Dai, Wenjing Tian, Yize Ma, Gangping Li, Lei Zhang, Yudong Jiang, Xiaohua Hou, Jun Song   +13 more
wiley   +1 more source

Microbiota dysbiosis induced by defect of paneth cells triggers visceral hypersensitivity in mice

, 2016
Microbiota dysbiosis induced by defect of paneth cells triggers visceral hypersensitivity in mice.
Riba, Ambre, Sommer, Caroline, Ménard, Sandrine, Cartier, Christel, Olier, Maïwenn, Theodorou, Vassilia, Alquier-Bacquié, Valérie, Baron, Marine, Harkat, Cherryl, Laurent, Fabrice, Lencina, Corinne, Mallet, Virginie, Gillet, Marion, Lamandé, Sonia   +13 more
core   +3 more sources

A selective, high affinity 5-HT_2Breceptor antagonist inhibits visceral hypersensitivity in rats

, 2010
A selective, high affinity 5-HT2Breceptor antagonist inhibits visceral hypersensitivity in ...
Y kurebayashi (19471153), D himaki (19471141), John Furness (13070439), M kawai (19471147), JD gale (19471150), K ohashi-doi (19471138), K nagao (19471144)   +6 more
core  

Investigating Interoceptive Beliefs in Individuals With Endometriosis

European Journal of Pain, Volume 30, Issue 10, November 2026.
ABSTRACT Background Research has indicated that individuals experiencing chronic pain differ in their ability to sense and interpret signals arising from inside the body, termed interoception. It is unclear whether differences in interoception exist for those with endometriosis, a common condition where pain is a major symptom. Methods This study aimed
Annabel Horsburgh, Aidan Lewis, Annaleise Naylor, Simon J. Summers, Richard J. Keegan, Paul Hoskins, Constantino Toufexis, Jack Mest, Andrew Flood   +8 more
wiley   +1 more source

Beyond Connection: Paradoxes of Psychedelic Resonance in Late Modernity

Future Humanities, Volume 4, Issue 2, November 2026.
ABSTRACT This essay explores the enduring suspicion that psychedelic experiences are antithetical to the structural dynamic of modern societies through Hartmut Rosa's concepts of ‘resonance’ and ‘social acceleration’. Rosa's theoretical framework is particularly generative for studying the social meaning of contemporary psychedelia because it enables a
Mateo Sanchez Petrement
wiley   +1 more source

Management of advanced mycosis fungoides and Sézary Syndrome: International Recommendations for systemic treatments and allogeneic hematopoietic cell transplantation from the European Hematology Association, the EORTC Cutaneous Lymphoma Tumours Group, the International Society for Cutaneous Lymphoma, and the Lymphoma Working Party of the EBMT

HemaSphere, Volume 10, Issue 11, November 2026.
Abstract Advanced mycosis fungoides (MF) and Sézary syndrome (SS) are the most aggressive forms of cutaneous T‐cell lymphoma and remain associated with a poor prognosis and heterogeneous therapeutic approaches. Recent advances, including targeted therapies and improved transplant strategies, have substantially expanded treatment options, highlighting ...
Francesco Onida, Pietro Quaglino, Julia Scarisbrick, Anna Sureda, Emmilia Hodak, Evangelia Papadavid, Silvia Alberti‐Violetti, Martine Bagot, Lorenzo Cerroni, Amrita Goyal‐O'Leary, Rudolf Stadler, Rein Willemze, Jasmine Zain, Marco Ardigò, Emilio Berti, Adèle de Masson, Rafael F. Duarte, Francine Foss, Eva González‐Barca, Joan Guitart, Pablo Ortiz‐Romero, Alessandro Pileri, Pierluigi Porcu, Henry M. Prince, Sima Rozati, Serena Rupoli, Maarten H. Vermeer, Sean Whittaker, Nicola Pimpinelli, Pier Luigi Zinzani   +29 more
wiley   +1 more source

Dengue Virus Pathogenesis: Innate Immune Signaling and Cell Death Receptor Pathways

Immunity, Inflammation and Disease, Volume 14, Issue 11, November 2026.
ABSTRACT Background The infection caused by the dengue virus (DENV) involves a complicated interaction between viral replication and the body's immune responses. As the first line of defense, the innate immune response limits viral replication but can also lead to immunopathology if it is improperly regulated.
Farjana Islam
wiley   +1 more source

ScRNA‐Seq Reveals Jiangfu Zhixie Formula Alleviates IBS‐D by Inhibiting Macrophage M1 Polarization through HIF‐1α‐Glycolysis Axis

Immunity, Inflammation and Disease, Volume 14, Issue 11, November 2026.
ABSTRACT Background Irritable bowel syndrome with diarrhea (IBS‐D) remains a challenging condition to manage due to its chronic nature and the limited long‐term efficacy of current treatments. The traditional Chinese herbal formula Jiangfu Zhixie (JFZX) has shown clinical benefits, but its underlying mechanisms remain unclear.
Xiaosong Xu, Yao Du, Lipeng Du, Wanning Zhang, Bowen Guo, Yanru Cai, Tianyi Zhang   +6 more
wiley   +1 more source

Transperineal Ultrasound in Chronic Pelvic Pain: A Systematic Review

Journal of Clinical Ultrasound, Volume 54, Issue 9, Page 2252-2268, November/December 2026.
Graphical abstract illustrating the systematic review process and highlighting key pelvic floor musculature (PFM) alterations detected by transperineal ultrasound (TPU) in patients with chronic pelvic pain (CPP) and associated conditions. These findings provide insights to enhance understanding and management of CPP.
Giulia Paoni Saccone, Noemi Tonti, Valeria Gangale, Maria Grazia Porpora, Federica Tomao, Violante Di Donato, Innocenza Palaia, Giusi Santangelo, Ludovico Muzii, Giuseppe Rizzo, Giorgia Perniola   +10 more
wiley   +1 more source

Intestinal Permeability in Irritable Bowel Syndrome With and Without Comorbid Conditions: Results From the European DISCOvERIE Cohort

United European Gastroenterology Journal, Volume 14, Issue 9, November 2026.
ABSTRACT Background Irritable bowel syndrome (IBS) is a disorder of gut‐brain interaction often accompanied by psychiatric and/or somatic comorbidities. Intestinal‐barrier dysfunction has been implicated in IBS pathophysiology. However, the contribution of psychiatric and somatic comorbidities to intestinal permeability remains unclear.
Alice Rustichelli, Juan Manuel Garcia‐Illarramendi, Javier Santos, Ana Maria González‐Castro, Magnus Simrén, Irina Midenfjord, Amanda Rodriguez‐Urrutia, Elba Expósito, Beatriz Lobo, Jose Alegre‐Martin, Miriam Almirall, Jesús Castro‐Marrero, Ramon Sanmartin‐Sentañes, Jan Tack, Florencia Carbone, Lukas Van Oudenhove, Maaike Van Den Houte, Liene Bervoets, Sybren Rinckhout, Daisy Jonkers, Michelle Bosman, Maria Raffaella Barbaro, Giovanni Barbara, Istvan Bitter, Eva Jekkel, Andreas Reif, Mareike Aichholzer, Carmen Uckermark, Alejandro Arias Vasquez, Dan Lucian Dumitrascu, Andrei‐Vasile Pop, Kristin Verbeke, Carmen Alonso‐Cotoner, Ricard Farré   +33 more
wiley   +1 more source