Results 101 to 110 of about 21,147 (220)

Estrogen-dependent visceral hypersensitivity following stress in rats: An fMRI study [PDF]

, 2016
We used functional MRI and a longitudinal design to investigate the brain mechanisms in a previously reported estrogen-dependent visceral hypersensitivity model. We hypothesized that noxious visceral stimulation would be associated with activation of the
da Silva, Joyce Teixeira, Traub, Richard J, Karpowicz, Jane M, Seminowicz, David A, Hubbard, Catherine, Furman, Andrew J   +5 more
core   +1 more source

Advances in the role of intestinal ion channels in the pathogenesis of irritable bowel syndrome [PDF]

Jichu yixue yu linchuang, 2020
Ion channels are widely present in mucous membranes of the digestive tract, their abnormal expression and(or) function are important pathogenic mechanisms of irritable bowel syndrome (IBS).
LAN Fei, LIU Tai-yang, YANG Jie
doaj  

Women in space: A review of known physiological adaptations and health perspectives

Experimental Physiology, EarlyView.
Abstract Exposure to the spaceflight environment causes adaptations in most human physiological systems, many of which are thought to affect women differently from men. Since only 11.5% of astronauts worldwide have been female, these issues are largely understudied.
Millie Hughes‐Fulford, Danielle J. Carroll, Heather C. M. Allaway, Bonnie J. Dunbar, Aenor J. Sawyer   +4 more
wiley   +1 more source

Microbiota dysbiosis induced by defect of enteric antimicrobial activity triggers visceral hypersensitivity in young adult mice [PDF]

, 2016
Paneth cell-derived antimicrobial peptides like lysozyme provide antibacterial protection and maintain intestinal homeostasis. We aimed to analyze the consequences of altered Paneth cells function on fecal antimicrobial activity, intestinal homeostasis ...
Riba, Ambre, Olier, Maiwenn, Sommer, Caroline, Ménard, Sandrine, Cartier, Christel, Salvador Cartier, Christel, Théodorou, Vassilia, Alquier-Bacquié, Valérie, Baron, Marine, Harkat, Cherryl, Laurent, Fabrice, Lencina, Corinne, Mallet, Virginie, Bacquié, Valérie, Gillet, Marion, Lamandé, Sonia, Lacroix Lamandé, Sonia   +16 more
core   +4 more sources

Inflammation, mechanical allodynia and an exaggerated exercise pressor reflex during disease progression in UCD‐type 2 diabetes mellitus rats

Experimental Physiology, EarlyView.
Abstract Chronic low‐grade inflammation characterizes type 2 diabetes mellitus (T2DM) and underlies the development of peripheral neuropathy, symptoms of which include mechanical allodynia and an exaggerated exercise pressor reflex. The purpose of this study was to determine whether mechanical allodynia and/or specific concentrations of inflammatory ...
Michelle L. Harrison, Richard K. McCuller, Yu Huo, Amshula N. Gajula, Kai Ybarbo, Mark J. Van Ryzin, Kimber L. Stanhope, Peter J. Havel, Audrey J. Stone   +8 more
wiley   +1 more source

Therapeutic potential of spexin in diabetic neuropathy: Insights from in vitro and in vivo models

Experimental Physiology, EarlyView.
Abstract The present study investigated the therapeutic potential of spexin (SPX) on both in vitro and in vivo models of diabetic neuropathy (DN). A total of 40 male BALB/c mice were randomly allocated into four experimental groups (n = 10 per group): a normoglycaemic control, an untreated DN group and two SPX treatment groups (DN+SPX‐12.5 and DN+SPX ...
Mehmet Refik Bahar, Seval Ulku Orhan, Cigdem Tekin, Asli Taslidere, Mete Ozcan, Suat Tekin   +5 more
wiley   +1 more source

Transient receptor potential ion channel function in sensory transduction and cellular signaling cascades underlying visceral hypersensitivity [PDF]

, 2017
Visceral hypersensitivity is an important mechanism underlying increased abdominal pain perception in functional gastrointestinal disorders including functional dyspepsia, irritable bowel syndrome, and inflammatory bowel disease in remission.
Mira M. Wouters, Karel Talavera, Dafne Balemans, Guy E. Boeckxstaens   +3 more
core   +1 more source

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

Pharmacological Inhibition of Cav2.2 Channels by Recombinant Phα1β Toxin (CTK01512‐2)

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 2, August 2026.
The recombinant Phα1β toxin (CTK01512‐2) partially and reversibly inhibits Cav2.2 calcium channels in HEK‐293 cells. CTK01512‐2 displays dose‐dependent inhibition of N‐type calcium currents, with an IC50 of 3.94 nM. In vivo, CTK01512‐2 effectively reduces mechanical allodynia in a neuropathic pain model, confirming its antinociceptive activity ...
Natália Virtude Carobin, Thamyris Reis Moraes, Luana Assis Ferreira, Christopher Kushmerick, Marcus Vinícius Gomez, Célio José Castro Junior   +5 more
wiley   +1 more source

Histamine H4 and H1 receptors contribute to postinflammatory visceral hypersensitivity [PDF]

, 2014
OBJECTIVES: Substantial evidence implicates mast cells and their main constituent histamine in the pathogenesis of visceral hypersensitivity. We explored the specific contribution of histamine H4 (H4R) and H1 (H1R) receptors to visceral hypersensitivity ...
Pelckmans, P., Pelckmans, Paul, Deiteren, A., De Winter, Benedicte, Moreels, Tom, Ruyssers, N., De Man, J., De Winter, B., de Man, Joris, Moreels, T., Ruyssers, Deiteren, Annemie   +11 more
core   +1 more source