Results 121 to 130 of about 184,182 (219)

A primary auditory cortex-anterior cingulate cortex circuit underlying cross-modal visceral pain modulation

Nature Communications
Visceral pain represents an unmet clinical need due to the lack of safe and generalizable therapies. Given the analgesic potential of music and the underlying crosstalk between auditory and nociceptive pathways, this study aims to delineate the neural ...
Yang Yu, Wen-Qiong Kuang, Yu-Hang He, Qian-Qian Chen, Yong-Chang Li, Fu-Chao Zhang, Hua-Dong Ni, Guang-Yin Xu   +7 more
doaj   +1 more source

Transient receptor potential ion channel function in sensory transduction and cellular signaling cascades underlying visceral hypersensitivity

, 2017
Visceral hypersensitivity is an important mechanism underlying increased abdominal pain perception in functional gastrointestinal disorders including functional dyspepsia, irritable bowel syndrome, and inflammatory bowel disease in remission.
Mira M. Wouters, Karel Talavera, Dafne Balemans, Guy E. Boeckxstaens   +3 more
core   +1 more source

Evaluating Whole Fruit Feijoa Powder for Type 2 Diabetes Risk Prevention: A Randomised Controlled Trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10709-10724, November 2026.
ABSTRACT Background Low energy diets (LEDs) are effective for body weight (BW) loss and improvement of type 2 diabetes (T2D) risk biomarkers. Emerging evidence suggests that whole fruit feijoa powder, rich in polyphenols and abscisic acid, may further support T2D prevention.
I. A. Mohamed, I. R. Sequeira‐Bisson, J. J. Lim, L. D. Plank, R. Murphy, S. D. Poppitt, J. L. Miles‐Chan   +6 more
wiley   +1 more source

Opioid Modulation of Major Neurotransmitter Systems: Acute, Chronic, and Withdrawal Effects

European Journal of Neuroscience, Volume 64, Issue 9, November 2026.
Opioids are widely used but also frequently misused drugs that affect multiple neurotransmitter systems, including dopaminergic, glutamatergic, GABAergic, serotonergic, and cholinergic pathways. Opioid‐induced neuroadaptations depend on the duration of drug exposure, with distinct changes also emerging following drug discontinuation.
Daniela Novakova, Eliska Pritulova, Jiri Novotny   +2 more
wiley   +1 more source

The long road to diagnosis, from gastroesophageal reflux disease, through Barrett's esophagus, to visceral hypersensitivity: a case report

Journal of Education, Health and Sport
Background: Visceral hypersensitivity syndrome is a condition involving excessive perception of mechanical stimuli in the intestines. In patients suffering from this disorder, physiological bowel function causes pain and discomfort.
Małgorzata Wirkijowska, Jolanta Mędyk, Yauheniya Patarocha, Michał Rogulski, Aleksandra Ślusarska, Paulina Błasiak, Patryk Mikołajec, Ruslan Huk, Barbara Bilecka, Jakub Wirkijowski   +9 more
doaj   +1 more source

Postelectroacupuncture Fecal Microbiota Transplantation (post‐EA FMT) Regulates Gastrointestinal Hormones in Functional Dyspepsia Rats Is Associated With Modulation of the Intestinal Microbiota‐Bile Acid Metabolic Pathway

Journal of Gastroenterology and Hepatology, Volume 41, Issue 11, Page 3466-3481, November 2026.
ABSTRACT Background Electroacupuncture (EA) reshapes intestinal flora; whether post‐EA fecal microbiota transplantation (post‐EA FMT) regulates gastrointestinal hormones via the gut microbiota–bile acid (BA) pathway remains unclear. Methods Sham EA (SEA) served as control. Gastrointestinal hormones/motility were assessed post‐EA.
Yong‐Li Han, Dong‐Fang Shang, Juli Tang, Dong‐Dong Yu, Liang‐Yu Zhang, Jing Zhou, Qing‐Bo Wang   +6 more
wiley   +1 more source

TRPA1 in the spinal dorsal horn is involved in post-inflammatory visceral hypersensitivity: in vivo study using TNBS-treated rat model

Journal of Pain Research, 2016
Qian Li,1,* Cheng-Hao Guo,2,* Mohammed Ali Chowdhury,1 Tao-Li Dai,1 Wei Han,1,3 1Department of Gastroenterology, Qilu Hospital of Shandong University, 2Department of Pathology, Medical School of Shandong University, 3Laboratory of Translational ...
Li Q, Guo C, Chowdhury MA, Dai T, Han W
doaj  

Lipotoxicity Amplifies IL‐6 Trans‐Signaling in Sinusoidal Endothelial Cells to Promote Endotheliopathy and Liver Injury

Journal of Gastroenterology and Hepatology, Volume 41, Issue 11, Page 3587-3599, November 2026.
ABSTRACT Background and Aims Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects approximately 25% of the global population and is a major health concern. Liver sinusoidal endothelial cells (LSECs) undergo morphological and functional alterations during MASLD progression, resulting in endotheliopathy characterized by pro ...
Yasuhiko Ueda, Nao Kawaguchi, Yosuke Inomata, Jun Arima, Mitsuaki Ishida, Yuko Ito, Sang‐Woong Lee, Kohei Taniguchi   +7 more
wiley   +1 more source

Microbiota From Human Infants Consuming Secretors Mothers' Milk Affects Murine Intestinal Motility and Enteric Nervous System Development in a Sex‐Dependent Manner

Neurogastroenterology &Motility, Volume 38, Issue 11, November 2026.
Early feeding influences the gut microbiome, which programs gut neuronal function later in life. Transferring gut bacteria from breastfed and formula‐fed infants into germ‐free mice revealed sex‐specific effects. Microbiota from infants of secretor mothers increased transit efficiency and nitrergic neurons in the large intestine of female mice, while ...
Bharath K. Kumar, Valentina Caputi, Kirandeep K. Gill, Bindu Nanduri, Tanya Leroith, Renee Fox, Fernanda Rosa, Joshua M. Lyte, Laxmi Yeruva   +8 more
wiley   +1 more source

Functional dyspepsia: the role of visceral hypersensitivity in its pathogenesis.

, 2012
Functional, or non-ulcer, dyspepsia (FD) is one of the most common reasons for referral to gastroenterologists. It is associated with significant morbidity and impaired quality of life.
Quigley, Eamonn M M, Keohane, John
core