The basolateral amygdala decodes visceral pain and itch via distinct circuits and molecules [PDF]
Nature CommunicationsAs aversive sensations, visceral pain and itch are highly refractory to conventional treatments. Accumulating evidence suggests that the basolateral amygdala (BLA) is involved in pain and itch; however, how the BLA segregates visceral pain and itch ...
Qiuying Zhao +10 more
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Molecular Mechanisms and Pathways in Visceral Pain [PDF]
CellsChronic visceral pain, a significant contributor to morbidity in the United States, affects millions and results in substantial economic costs. Despite its impact, the mechanisms underlying disorders of gut–brain interaction (DGBIs), such as irritable ...
Qiqi Zhou, George Nicholas Verne
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A primary auditory cortex-anterior cingulate cortex circuit underlying cross-modal visceral pain modulation [PDF]
Nature CommunicationsVisceral pain represents an unmet clinical need due to the lack of safe and generalizable therapies. Given the analgesic potential of music and the underlying crosstalk between auditory and nociceptive pathways, this study aims to delineate the neural ...
Yang Yu +7 more
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The enhanced analgesic effects of electroacupuncture and repetitive transcranial magnetic stimulation on visceral pain via ventral lateral septal nucleus [PDF]
Molecular PainIrritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized primarily by chronic visceral pain, with a complex pathogenesis and limited efficacy of current therapeutic interventions.
Rui-Xia Weng +10 more
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Paraventricular hypothalamic input to anterior cingulate cortex controls food preferences in chronic visceral pain mice [PDF]
Nature CommunicationsChronic visceral pain is frequently accompanied by changes in food preference. The paraventricular hypothalamus (PVH) and the anterior cingulate cortex (ACC) are well-known regions involved in pain processing and food intake.
Qi-Ya Xu +9 more
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Costly pain avoidance and its impact on the modulation and extinction of visceral pain-related fear [PDF]
Scientific ReportsAlong the gut-brain axis, visceral pain demonstrably evokes emotional learning and memory processes shaping behavior in clinically relevant ways. Avoidance motivated by learned fear may constitute a major obstacle to treatment success in extinction-based
Franziska Labrenz +3 more
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Neural circuits regulating visceral pain [PDF]
Communications BiologyVisceral hypersensitivity, a common clinical manifestation of irritable bowel syndrome, may contribute to the development of chronic visceral pain, which is a major challenge for both patients and health providers.
Xiaoli Chang +2 more
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Neuroimaging of Visceral Pain [PDF]
Reviews in Pain, 2009 • Functional neuroimaging allows conscious reporting by human subjects to be related to changes in brain activation during painful stimulation. • Brain regions thought to be involved in the perception of pain include the primary and secondary somatosensory cortex, the anterior cingulate cortex, the prefrontal cortex, the insula and the thalamus ...
Emily, Johns, Irene, Tracey
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Paclitaxel—A Valuable Tool for Inducing Visceral Pain in Preclinical Testing?
International Journal of Translational Medicine, 2023 Visceral pain is a unique clinical entity that lacks an effective and safe treatment. Proper preclinical models are essential for assessing new drugs developed for the treatment of this pathology.
Corina Andrei +3 more
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Stress-Induced Chronic Visceral Pain of Gastrointestinal Origin
Frontiers in Systems Neuroscience, 2017 Visceral pain is generally poorly localized and characterized by hypersensitivity to a stimulus such as organ distension. In concert with chronic visceral pain, there is a high comorbidity with stress-related psychiatric disorders including anxiety and ...
Beverley Greenwood-Van Meerveld +3 more
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