Results 71 to 80 of about 57,239 (306)

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source

Impacto da terapia manual visceral na melhora da qualidade de vida de pacientes com dor abdominal crônica

Revista Dor
JUSTIFICATIVA E OBJETIVOS: A dor abdominal secundária à constipação intestinal crônica funcional (CICF) afeta uma proporção substancial de pessoas, especialmente mulheres. O objetivo deste estudo foi avaliar a eficácia da terapia manual visceral (TMV) em
Barbara Borges Ferraz, Marielza R. Ismael Martins, Marcos Henrique Dall'Aglio Foss   +2 more
doaj   +1 more source

Urolitíase pediátrica: experiência de um hospital infantil de cuidados terciários

Brazilian Journal of Nephrology, 2016
Resumo Introdução: A urolitíase pediátrica tornou-se mais prevalente nas últimas décadas, com altas taxas de recorrência e considerável morbidade.
Luana Amancio, Maira Fedrizzi, Nilzete Liberato Bresolin, Maria Goretti Moreira Guimarães Penido   +3 more
doaj   +1 more source

Description of the larval stages of Gymnochthebius jensenhaarupi and phylogenetic analysis of the relationships with other species of the subfamily Ochthebiinae (Coleoptera: Hydraenidae) [PDF]

, 2005
The three larval instars of Gymnochthebius jensenhaarupi (Knisch, 1924) are described and illustrated, including a detailed analysis of their chaetotaxy and porotaxy. The specimens used in this study were collected with adults of G.
Archangelsky, Miguel, Delgado, Juan A.
core   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Phase Ib study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis

Hepatology, EarlyView., 2022
Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...
Jun Zhou, Yongkun Sun, Wen Zhang, Jiajia Yuan, Zhi Peng, Wei Wang, Jifang Gong, Lin Yang, Yanshuo Cao, Hong Zhao, Chao Chen, Weifeng Wang, Lin Shen, Aiping Zhou   +13 more
wiley   +1 more source

Superior mesenteric artery compression syndrome - case report

Journal of Coloproctology, 2011
Superior mesenteric artery syndrome is an entity generally caused by the loss of the intervening mesenteric fat pad, resulting in compression of the third portion of the duodenum by the superior mesenteric artery.
Paulo Rocha França Neto, Rodrigo de Almeida Paiva, Antônio Lacerda Filho, Fábio Lopes de Queiroz, Teon Noronha   +4 more
doaj   +1 more source

DOR ABDOMINAL NA EMERGÊNCIA: ENTENDENDO O MANEJO

Periódicos Brasil. Pesquisa Científica
Introdução: A dor abdominal é uma queixa comum na prática médica, especialmente nas emergências, onde a rapidez e a precisão do diagnóstico são cruciais para o manejo eficaz. Metodologia: A metodologia para abordar o manejo da dor abdominal na emergência envolve uma série de etapas sistemáticas e interligadas.
Silvano Alves da Silva, Manuella Meneses Chaves, Sophya Bezerra Silva Rocha, Rhaira Fernanda Ayoub Casalvara, Fernanda Marinho de Souza, Enzzo Cavalcante Pereira, Guilherme Protázio Oliveira Pires de Sá, Julia Cordeiro Schneider Ferreira, Fernando Rodrigues Dias, Fillipe Eduardo Amorim Mesquita, Thúlio Willen Siqueira Neder   +10 more
openaire   +1 more source

Generic changes in United States Issini (Hemiptera, Fulgoroidea, Issidae) [PDF]

, 2006
Three new genera of the family Issidae are described for species formerly included in the genus Hysteropterum sensu lato: Balduza Gnezdilov and O’Brien, gen. n. (type species: Hysteropterum unum Ball 1910), Stilbometopius Gnezdilov and O’Brien, gen.
Gnezdilov, Vladimir M., O'Brien, Lois B.
core   +1 more source

Real‐Time In Vivo Monitoring of Anastomotic Intestinal Ischemia Using Implantable Resorbable Organic Sensors

Advanced Science, EarlyView.
Resorbable impedance sensors are successfully implanted into porcine small intestinal anastomoses. Impedance was recorded for 2 hours prior, and 2 hours following ischemia induction, and a significant drop in tissue impedance was observed. Abstract Anastomotic failure remains one of the most severe complications in gastrointestinal surgery.
Dennis Wahl, Finn Jaekel, Julia Henne, Richard Kantelberg, Daniel C. Freund, Eberhard Grambow, Brigitte Vollmar, Amelie R. Zitzmann, Hans Kleemann, Jochen Hampe, Sebastian Hinz, Clemens Schafmayer, Karl Leo   +12 more
wiley   +1 more source