Results 91 to 100 of about 229,236 (394)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Summer Dormancy in Perennial Cool-Season Forage Grasses
Türkiye Tarımsal Araştırmalar Dergisi, 2018 Plants survive in unfavorable environmental conditions by developing some strategies. One of these strategies is dormancy. This article was prepared to provide information about the summer dormancy of plants in summer. Summer dormancy is a type of endo-
Özlem ÖNAL AŞCI, Ömer EĞRİTAŞ
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Horticulturae, 2023 Euphorbia maculata L. has been confirmed to have functional properties, including anticytotoxic, anti-inflammatory, and antioxidative effects. However, studies on the dormancy and germination of its seeds for cultivation purposes are lacking.
Kyungtae Park +3 more
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Autophagy-deficient breast cancer shows early tumor recurrence and escape from dormancy [PDF]
, 2018 Breast cancer patients who initially respond to cancer therapies often succumb to distant recurrence of the disease. It is not clear why people with the same type of breast cancer respond to treatments differently; some escape from dormancy and relapse ...
Manjili, Masoud H.
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Mechanism of endocarp-imposed constraints of germination of Lannea microcarpa seeds [PDF]
, 2008 Lannea microcarpa, a multipurpose tree species from the dry African savanna, sheds seeds that often display inhibition of germination. The underlying mechanism was investigated using seeds processed from fully matured fruits collected from natural stands
Golovina, E.A., Hoekstra, F.A., Neya, O.
core +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
A laboratory simulation of Arabidopsis seed dormancy cycling provides new insight into its regulation by clock genes and the dormancy-related genes DOG1 , MFT , CIPK23 and PHYA [PDF]
, 2017 Environmental signals drive seed dormancy cycling in the soil to synchronise germination with the optimal time of year; a process essential for species fitness and survival.
Finch-Savage, William E. +3 more
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FEBS Open Bio, EarlyView.Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu +6 more
wiley +1 more source
Inflammatory cytokines mediate the induction of and awakening from metastatic dormancy
Cell ReportsSummary: Metastases arise from disseminated cancer cells (DCCs) that detach from the primary tumor and seed distant organs. There, quiescent DCCs can survive for an extended time, a state referred to as metastatic dormancy.
Paulo Pereira +10 more
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Some considerations concerning the germination and dormant period of seeds
Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 1996 The storage of dormancy or active life in seed is on their chemical composition and anatomic structure, as well on environmental factors. According to the season upon which seeds enter or are in dormancy, one can discern a primary and a secondary ...
Alexandru SALONTAI
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