Results 101 to 110 of about 128,870 (374)

How the interplay of dormancy and selection affects the wave of advance of an advantageous gene [PDF]

arXiv, 2021
In this paper we investigate the spread of advantageous genes in two variants of the F-KPP model with dormancy. The first variant, in which dormant individuals do not move in space and instead form "localized seed banks", has recently been introduced in Blath, Hammer and Nie (2020).
arxiv  

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Earthing effects on mitochondrial function: ATP production and ROS generation

FEBS Open Bio, EarlyView.
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley   +1 more source

Tumor dormancy in bone

Cancer Reports, 2019
AbstractBackgroundBone marrow is a common site of metastasis for a number of tumor types, including breast, prostate, and lung cancer, but the mechanisms controlling tumor dormancy in bone are poorly understood. In breast cancer, while advances in drug development, screening practices, and surgical techniques have dramatically improved survival rates ...
Tolu Omokehinde, Rachelle W. Johnson, Rachelle W. Johnson, Vera Mayhew   +3 more
openaire   +4 more sources

Overexpression of Prunus DAM6 inhibits growth, represses bud break competency of dormant buds and delays bud outgrowth in apple plants.

PLoS ONE, 2019
Most deciduous fruit trees cultivated in the temperate zone require a genotype-dependent amounts of chilling exposure for dormancy release and bud break.
Hisayo Yamane, Masato Wada, Chikako Honda, Takakazu Matsuura, Yoko Ikeda, Takashi Hirayama, Yutaro Osako, Mei Gao-Takai, Mikiko Kojima, Hitoshi Sakakibara, Ryutaro Tao   +10 more
doaj   +1 more source

I Want to (Bud) Break Free: The Potential Role of DAM and SVP-Like Genes in Regulating Dormancy Cycle in Temperate Fruit Trees

Frontiers in Plant Science, 2019
Bud dormancy is an adaptive process that allows trees to survive the hard environmental conditions that they experience during the winter of temperate climates.
V. S. Falavigna, Baptiste Guitton, E. Costes, F. Andrés   +3 more
semanticscholar   +1 more source

Validity and Reliability of Clinical and Patient‐Reported Outcomes in Multisystem Proteinopathy 1

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Valosin‐containing protein (VCP)‐associated multisystem proteinopathy 1 (MSP1) is caused by variants in the VCP gene. MSP1 results in various phenotypes including progressive myopathy, Paget's disease of bone, frontotemporal dementia, amyotrophic lateral sclerosis, and parkinsonism, among others.
Lindsay N. Alfano, Megan A. Iammarino, Natalie F. Reash, Linda P. Lowes, Lindsay Pietruszewski, Kathleen Adderley, Lauren Humphrey, Audrey B. Knight, Christopher L. Steiner, Melissa A. Smith, Zarife Sahenk, Anne M. Connolly, Momen Almomen, Eleonora S. D'Ambrosio, Nathan Peck, Allison Peck   +15 more
wiley   +1 more source

Stromal changes in the aged lung induce an emergence from melanoma dormancy

Nature, 2022
Mitchell E. Fane, Yash Chhabra, Gretchen M. Alicea, Devon A. Maranto, Stephen M. Douglass, Marie R. Webster, V. Rebecca, Gloria E. Marino, Filipe V Almeida, B. Ecker, Daniel J. Zabransky, Laura Hüser, T. Beer, Hsin-Yao Tang, A. Kossenkov, M. Herlyn, D. Speicher, Wei Xu, Xiaowei Xu, E. Jaffee, J. Aguirre-Ghiso, A. Weeraratna   +21 more
semanticscholar   +1 more source

Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression

Nature Communications, 2019
Breast cancer stem cells (BCSCs) are unique in their ability to undergo unlimited self-renewal, an essential process in breast cancer recurrence following metastatic dormancy.
Alyssa La Belle Flynn, B. Calhoun, Arishya Sharma, Jenny C. Chang, A. Almasan, W. Schiemann   +5 more
semanticscholar   +1 more source