Results 111 to 120 of about 127,678 (374)
Novel Phenotypes and Deep Intronic Variant Expand TH‐Associated Dopa‐Responsive Dystonia Spectrum
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Approximately 20% of dopa‐responsive dystonia (DRD) cases remain genetically unresolved. Using whole‐genome sequencing, we identified two TH variants in a young DRD patient, including a novel deep intronic variant. Minigene assays confirmed that this variant causes aberrant splicing.
Xiaosheng Zheng +6 more
wiley +1 more source
Seed Germination and Dormancy.
The Plant Cell, 1997 Seeds are a vital component of the world’s diet. Cereal grains alone, which comprise -90% of all cultivated seeds, contribute up to half of the global per capita energy intake. Not surprisingly then, seed biology is one of the most extensively researched
J. Bewley
semanticscholar +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Certain frontotemporal lobar degeneration subtypes, including TDP‐A and B, can either occur sporadically or in association with specific genetic mutations. It is uncertain whether syndromic or imaging features previously associated with these patient groups are subtype or genotype specific.
Sean Coulborn +17 more
wiley +1 more source
Control of seed dormancy and germination by DOG1-AHG1 PP2C phosphatase complex via binding to heme
Nature Communications, 2018 Abscisic acid (ABA) regulates abiotic stress and developmental responses including regulation of seed dormancy to prevent seeds from germinating under unfavorable environmental conditions. ABA HYPERSENSITIVE GERMINATION1 (AHG1) encoding a type 2C protein
N. Nishimura +11 more
semanticscholar +1 more source
Longitudinal Trajectories of Digital Cognitive Biomarkers for Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Cognitive impairment is one of the most common and debilitating symptoms of relapsing–remitting multiple sclerosis (RRMS). Digital cognitive biomarkers require less time and resources and are rapidly gaining popularity in clinical settings.
Yi Chao Foong +17 more
wiley +1 more source
Claustrum Volume Is Reduced in Multiple Sclerosis and Predicts Disability
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The claustrum is a small, thin structure of predominantly gray matter with broad connectivity and enigmatic function. Little is known regarding the impact of claustrum pathology in multiple sclerosis (MS). Methods This study assessed whether claustrum volume was reduced in MS and whether reductions were associated with specific ...
Nicole Shelley +5 more
wiley +1 more source
The grain yield modulator miR156 regulates seed dormancy through the gibberellin pathway in rice
Nature Communications, 2019 The widespread agricultural problem of pre-harvest sprouting (PHS) could potentially be overcome by improving seed dormancy. Here, we report that miR156, an important grain yield regulator, also controls seed dormancy in rice.
Chunbo Miao +7 more
semanticscholar +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Music interventions have been shown to have beneficial effects on hemodynamic parameters, pain, and anxiety in various medical settings. However, music interventions in the setting of acute stroke have not been studied. The objective of this trial was to perform a pilot feasibility study of music interventions in the setting of acute
Jeffrey J. Fletcher +7 more
wiley +1 more source
Breeding for reduced seed dormancy to domesticate new grass species [PDF]
Genetics and Molecular BiologyIntroducing new grass species into cultivation has long been proposed as beneficial to increase the sustainability and diversity of productive systems.
Nicolás Glison +3 more
doaj +1 more source