Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao+14 more
wiley +1 more source
Paving the way to secondary dormancy: mind the DOG's tail. [PDF]
Cao D.
europepmc +1 more source
Factors Influencing Dormancy of Peanut Seeds [PDF]
Vivian K. Toole+2 more
openalex +1 more source
Chromatin Organization Governs Transcriptional Response and Plasticity of Cancer Stem Cells
Through a combination of transcriptomic and histone mapping studies integrated with chromatin imaging, we define how chromatin organization in nanoscale packing domains fine tunes the plasticity of cancer stem cells (CSCs) driving evasion from and survival after chemotherapy.
Yinu Wang+20 more
wiley +1 more source
Effect of Temperature and Covering Structures in Seed Dormancy and Germination Traits of Manchurian Striped Maple (<i>Acer tegmentosum</i> Maxim.) Native to Northeast Asia. [PDF]
Kim S, Ko CH, Kwon HC, Rhie YH, Lee SY.
europepmc +1 more source
Rest Intensity of Dormant Peach and Apricot Leaf Buds as Influenced By Temperature, Cold Hardiness and Respiration1 [PDF]
Anthony H. Hatch, D. R. Walker
openalex +1 more source
α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model
A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro+14 more
wiley +1 more source
Towards understanding cancer dormancy over strategic hitching up mechanisms to technologies. [PDF]
Yang S+8 more
europepmc +1 more source
Prunin Identification, Biological Activity and Quantitative Change in Comparison to Naringenin in Dormant Peach Buds [PDF]
A. Erez, S. Lavee
openalex +1 more source