Results 1 to 10 of about 26,172 (170)

Bioengineered models to study tumor dormancy [PDF]

Journal of Biological Engineering, 2019
The onset of cancer metastasis is the defining event in cancer progression when the disease is considered lethal. The ability of metastatic cancer cells to stay dormant for extended time periods and reawaken at later stages leading to disease recurrence ...
Shreyas S. Rao, Raghu Vamsi Kondapaneni, Akshay A. Narkhede   +2 more
doaj   +5 more sources

The Relationship Between Mesenchymal Stem Cells and Tumor Dormancy [PDF]

Frontiers in Cell and Developmental Biology, 2021
Tumor dormancy, a state of tumor, is clinically undetectable and the outgrowth of dormant tumor cells into overt metastases is responsible for cancer-associated deaths.
Linxian Zhao, Kai Zhang, Hongyu He, Yongping Yang, Wei Li, Tongjun Liu, Jiannan Li   +6 more
doaj   +2 more sources

Tumor cell dormancy [PDF]

Molecular Oncology, 2017
Metastasis is the primary cause of death in cancer patients and current treatments fail to provide durable responses. Efforts to treat metastatic disease are hindered by the fact that metastatic cells often remain dormant for prolonged intervals of years,
Aceto, Adam, Aguirre-Ghiso, Aguirre-Ghiso, Aguirre-Ghiso, Alix-Panabieres, Balz, Berx, Bidwell, Bos, Brabletz, Bragado, Cameron, Casanova, Celia-Terrassa, Coleman, Coleman, Coleman, Conejo-Garcia, Cox, Deng, Duda, Dumont, Early Breast Cancer Trialists’ Collaborative Group, Erler, Ewton, Eyles, Feuerer, Gao, Gao, Ghajar, Giampieri, Giancotti, Goss, Gupta, Gupta, Hess, Hickson, Howlader, Ibrahim, Jin, Joyce, Kang, Kang, Kaplan, Kelly, Kessenbrock, Klein, Klein, Kobayashi, Kozlow, Labelle, Labelle, Lawler, Lawson, Lawson, Lu, Lu, Luzzi, Lyden, Malanchi, Malladi, Mani, Massague, Minn, Mitra, Morales, Moretta, Morikawa, Muller, Nesbitt, Nguyen, Nieswandt, Obenauf, Ocana, Osisami, Oskarsson, Padua, Paolino, Pavlovic, Peinado, Pozo Martin, Qian, Roger R. Gomis, Schewe, Sequeira, Sethi, Shankaran, Shiozawa, Smith, Smyth, Sosa, Sparmann, Stephens, Straume, Strauss, Sylwia Gawrzak, Tierney, Torrano, Trumpp, Urosevic, Valastyan, Valiente, Vander Griend, Vleminckx, Wang, Wang, Wculek, Weilbaecher, Wells, White, Willis, Wolf, Wyckoff, Yin, Yoneda, Yu, Yu, Zhang, Zhang   +119 more
core   +5 more sources

Remodeling the tumor dormancy ecosystem to prevent recurrence and metastasis [PDF]

Signal Transduction and Targeted Therapy
Dormant tumor cells, major contributors to tumor recurrence and metastasis, are characterized by cell cycle arrest and reactivation potential. Tumor dormancy arises from the dynamic interplay between intrinsic tumor properties and extrinsic factors ...
Yu Liang, Wo-Ming Chen, Youming Zhang, Lei Li   +3 more
doaj   +2 more sources

Tumor Dormancy: Biologic and Therapeutic Implications. [PDF]

World J Oncol, 2022
Metastatic cancer can arise years after treatment of the primary tumor because residual tumor cells can enter dormancy and evade elimination by anti-neoplastic therapies. The mechanisms underlying this phenomenon have been investigated and a number of hypotheses have been proposed.
Balayan V, Guddati AK.
europepmc   +4 more sources

Tumor Dormancy and Reactivation: The Role of Heat Shock Proteins [PDF]

Cells
Tumors are a heterogeneous group of cell masses originating in various organs or tissues. The cellular composition of the tumor cell mass interacts in an intricate manner, influenced by humoral, genetic, molecular, and tumor microenvironment cues that ...
Haneef Ahmed Amissah, Stephanie E. Combs, Maxim Shevtsov   +2 more
doaj   +2 more sources

Tumor dormancy in bone. [PDF]

Cancer Rep (Hoboken), 2020
AbstractBackgroundBone marrow is a common site of metastasis for a number of tumor types, including breast, prostate, and lung cancer, but the mechanisms controlling tumor dormancy in bone are poorly understood. In breast cancer, while advances in drug development, screening practices, and surgical techniques have dramatically improved survival rates ...
Mayhew V, Omokehinde T, Johnson RW.
europepmc   +4 more sources

Sleepyhead, deadly awakening: the dynamics of metastatic organotropism, tumor dormancy and therapeutic implications [PDF]

Frontiers in Oncology
As per the global mortality-related data, metastasis and tumor-related relapse are the major determinants of cancer-related deaths. This phenomenon is largely driven by tumor dormancy - a state in which disseminated tumor cells (DTCs) persist in a non ...
Soumyajit Sarkar, Suresh P. K.
doaj   +2 more sources

Tumor Dormancy: Implications for Invasion and Metastasis. [PDF]

Int J Mol Sci, 2021
Tumor dormancy refers to a critical stage of cancer development when tumor cells are present, but cancer does not progress. It includes both the concept of cellular dormancy, indicating the reversible switch of a cancer cell to a quiescent state, and that of tumor mass dormancy, indicating the presence of neoplastic masses that have reached cell ...
Gomatou G, Syrigos N, Vathiotis IA, Kotteas EA.   +3 more
europepmc   +5 more sources

Tumor dormancy and relapse: understanding the molecular mechanisms of cancer recurrence [PDF]

Military Medical Research
Cancer recurrence, driven by the phenomenon of tumor dormancy, presents a formidable challenge in oncology. Dormant cancer cells have the ability to evade detection and treatment, leading to relapse.
Muhammad Tufail, Can-Hua Jiang, Ning Li
doaj   +2 more sources