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Microenvironments Dictating Tumor Cell Dormancy [PDF]
, 2012 The mechanisms driving dormancy of disseminated tumor cells (DTCs) remain largely unknown. Here, we discuss experimental evidence and theoretical frameworks that support three potential scenarios contributing to tumor cell dormancy. The first scenario proposes that DTCs from invasive cancers activate stress signals in response to the dissemination ...
Paloma, Bragado +4 more
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Autophagy and Hepatic Tumor Microenvironment Associated Dormancy
Journal of Gastrointestinal Cancer, 2021 The goal of successful cancer treatment is targeting the eradication of cancer cells. Although surgical removal of the primary tumors and several rounds of chemo- and radiotherapy reduce the disease burden, in some cases, asymptomatic dormant cancer cells may still exist in the body. Dormant cells arise from the disseminated tumor cells (DTCs) from the
Yunus Akkoc, Devrim Gozuacik
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Microenvironment in neuroblastoma: Isolation and characterization of tumor-derived mesenchymal stromal cells [PDF]
, 2018 Background: It has been proposed that mesenchymal stromal cells (MSCs) promote tumor progression by interacting with tumor cells and other stroma cells in the complex network of the tumor microenvironment. We characterized MSCs isolated and expanded from
Apuzzo T. +14 more
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The Potential for Circulating Tumor Cells in Pancreatic Cancer Management. [PDF]
, 2017 Pancreatic cancer is one the most lethal malignancies. Only a small proportion of patients with this disease benefit from surgery. Chemotherapy provides only a transient benefit.
Michael Pimienta +4 more
core +2 more sources
Tumor dormancy and oncogene addiction [PDF]
APMIS, 2008 Cancer is caused by genetic changes that activate oncogenes or inactivate tumor suppressor genes. The repair or inactivation of mutant genes may be effective in the treatment of cancer. Indeed, drugs that target oncogenes can be effective in the treatment of cancer.
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Cancer stem cells, tumor dormancy, and metastasis [PDF]
Frontiers in Endocrinology, 2012 Tumor cells can persist undetectably for an extended period of time in primary tumors and in disseminated cancer cells. Very little is known about why and how these tumors persist for extended periods of time and then evolve to malignancy. The discovery of cancer stem cells (CSCs) in human tumors challenges our current understanding of tumor recurrence,
Patel, Purvi, Chen, Emily I.
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The chloride channel cystic fibrosis transmembrane conductance regulator (CFTR) controls cellular quiescence by hyperpolarizing the cell membrane during diapause in the crustacean Artemia [PDF]
, 2019 Cellular quiescence, a reversible state in which growth, proliferation, and other cellular activities are arrested, is important for self-renewal, differentiation, development, regeneration, and stress resistance.
Bossier, Peter +10 more
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Tumor Cell Dormancy—Triggered by the Niche [PDF]
Developmental Cell, 2019 Dormant cancer cells often survive treatment and increase the risk for tumor relapse, associated with dismal prognosis. Two recent papers describe mechanisms used by the bone marrow niche to regulate leukemia dormancy. The findings provide a molecular basis for niche-targeting therapies that may enable elimination of dormant tumor cells.
Senft, D., Jeremias, I.
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Review of Tumor Dormancy Therapy Using Traditional Oriental Herbal Medicine
Journal of Pharmacopuncture, 2013 Objective: Standard cancer therapy prolongs survival, but can be detrimental to the quality of life, compromise the immune system, and leave residual disease that can cause recurrence years or decades in the future.
Lee Jong-Ho +4 more
doaj +1 more source
Fibroblasts in cancer dormancy: foe or friend?
Cancer Cell International, 2021 Cancer dormancy is defined that the residual cancer cells could enter into a state of quiescence and patients remain asymptomatic for years or even decades after anti-tumor therapies.
Li Dai +5 more
doaj +1 more source