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Journal of Experimental & Clinical Cancer Research, 2023 Background Disseminated tumor cells (DTCs) can enter a dormant state and cause no symptoms in cancer patients. On the other hand, the dormant DTCs can reactivate and cause metastases progression and lethal relapses.
Ruihua Liu +10 more
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A cellular automaton model for tumor dormancy: emergence of a proliferative switch. [PDF]
PLoS ONE, 2014 Malignant cancers that lead to fatal outcomes for patients may remain dormant for very long periods of time. Although individual mechanisms such as cellular dormancy, angiogenic dormancy and immunosurveillance have been proposed, a comprehensive ...
Duyu Chen, Yang Jiao, Salvatore Torquato
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Recent Insights into Mechanisms Governing Breast Cancer Dormancy
Zhongliu Fangzhi Yanjiu, 2023 Tumor dormancy refers to the status of disseminated cancer cells that remain in a viable yet not proliferating state for a prolonged period. Dormant cells will eventually "re-awake" resume their proliferation, and produce overt metastasis.
MA Lanjing, ZHANG Baihong
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Tumor‐vascular interactions and tumor dormancy [PDF]
APMIS, 2008 Tumor progression is dependent on a number of sequential steps, including initial tumor‐vascular interactions and recruitment of blood vessels (i.e., the angiogenic switch), as well as tumor cells interacting with the surrounding microenvironment and its different components.
George N, Naumov +3 more
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Mechanisms of Metastatic Tumor Dormancy [PDF]
Journal of Clinical Medicine, 2013 Tumor metastasis can occur years after an apparent cure due to a phenomenon known as metastatic tumor dormancy; in which tumor masses or individual tumor cells are growth restricted for extended periods of time. This period of dormancy is induced and maintained by several mechanisms, including: (1) Tumor microenvironment factors such as cytokine ...
Osisami, Mary, Keller, Evan T.
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Global Dormancy of Metastases Due to Systemic Inhibition of Angiogenesis [PDF]
, 2014 Autopsy studies of adults dying of non-cancer causes have shown that virtually all of us possess occult, cancerous lesions. This suggests that, for most individuals, cancer will become dormant and not progress, while only in some will it become ...
Benzekry, Sébastien +2 more
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Cancer therapeutic potential of combinatorial immuno- and vaso-modulatory interventions [PDF]
, 2015 Currently, most of the basic mechanisms governing tumor-immune system interactions, in combination with modulations of tumor-associated vasculature, are far from being completely understood.
Alfonso, J. C. L. +5 more
core +3 more sources
Targeting Immune-Mediated Dormancy: A Promising Treatment of Cancer
Frontiers in Oncology, 2019 Immune-mediated dormancy is when the immune system keeps proliferating tumor cells unchanged, mostly via cytotoxic activity of immune cells. Cancer dormancy, especially immune-mediated dormancy, may be the explanation for tumor refractory and may be ...
Hao-fan Wang +6 more
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Tumor-reactive immune cells protect against metastatic tumor and induce immunoediting of indolent but not quiescent tumor cells [PDF]
, 2016 Two major barriers to cancer immunotherapy include tumor-induced immune suppression mediated by myeloid-derived suppressor cells and poor immunogenicity of the tumor-expressing self-antigens.
Bear, Harry D. +8 more
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TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling [PDF]
, 2013 In patients, non-proliferative disseminated tumour cells (DTCs) can persist in the bone marrow (BM) while other organs (such as lung) present growing metastasis.
Aguirre Ghiso, Julio A. +7 more
core +2 more sources