Advances in the molecular regulation mechanism of tumor dormancy and its therapeutic strategy [PDF]
Discover OncologyTumor dormancy is a stage in the growth and development of malignant cells and is one of the biological characteristics of malignant cells. Complex transitions involving dormant tumor cells between quiescent and proliferative states pose challenges for ...
Yuan Wang +7 more
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Local and distant tumor dormancy during early stage breast cancer are associated with the predominance of infiltrating T effector subsets [PDF]
Breast Cancer Research, 2020 Background Although breast cancer mortality is a result of distant recurrences associated with the establishment of tumor dormancy, current clinical practice guidelines recommend a wait and watch approach for tumor recurrences.
Hussein F. Aqbi +13 more
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Tumor Dormancy and Interplay with Hypoxic Tumor Microenvironment. [PDF]
Int J Mol Sci, 2019 The tumor microenvironment is a key factor in disease progression, local resistance, immune-escaping, and metastasis. The rapid proliferation of tumor cells and the aberrant structure of the blood vessels within tumors result in a marked heterogeneity in the perfusion of the tumor tissue with regions of hypoxia.
Butturini E +3 more
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Tumor dormancy and disease recurrence. [PDF]
Cancer Metastasis Rev, 2023 Kirkland JL.
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Engineered In Vitro Models of Tumor Dormancy and Reactivation [PDF]
Journal of Biological Engineering, 2018 Metastatic recurrence is a major hurdle to overcome for successful control of cancer-associated death. Residual tumor cells in the primary site, or disseminated tumor cells in secondary sites, can lie in a dormant state for long time periods, years to ...
Shantanu Pradhan +3 more
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Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy [PDF]
Cells, 2020 Here, we provide an overview of the importance of cellular fate in cancer as a group of diseases of abnormal cell growth. Tumor development and progression is a highly dynamic process, with several phases of evolution.
Francisco Triana-Martínez +2 more
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Tumor Dormancy and Slow-Cycling Cancer Cells. [PDF]
Adv Exp Med Biol, 2019 Cancer cell heterogeneity is a universal feature of human tumors and represents a significant barrier to the efficacy and duration of anticancer therapies, especially targeted therapeutics. Among the heterogeneous cancer cell populations is a subpopulation of relatively quiescent cancer cells, which are in the G0/G1 cell-cycle phase and refractory to ...
Davis JE, Kirk J, Ji Y, Tang DG.
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Inhibition of DEC2 is necessary for exiting cell dormancy in salivary adenoid cystic carcinoma
Journal of Experimental & Clinical Cancer Research, 2021 Background Patients were prone to have poor prognosis once dormant tumor cells being reactivated. However, the molecular mechanism of tumor cell dormancy remains poorly understood.
Xiao Yang +10 more
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Dormancy signatures and metastasis in estrogen receptor positive and negative breast cancer. [PDF]
PLoS ONE, 2012 Breast cancers can recur after removal of the primary tumor and treatment to eliminate remaining tumor cells. Recurrence may occur after long periods of time during which there are no clinical symptoms.
Ryung S Kim +6 more
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Pan-Cancer Survey of Tumor Mass Dormancy and Underlying Mutational Processes
Frontiers in Cell and Developmental Biology, 2021 Tumor mass dormancy is the key intermediate step between immune surveillance and cancer progression, yet due to its transitory nature it has been difficult to capture and characterize. Little is understood of its prevalence across cancer types and of the
Anna Julia Wiecek +4 more
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