The acceleration of metastases after tumor removal and the paradoxical phenomenon of concomitant tumor resistance [PDF]
, 2018 Although surgical extirpation of tumors is usually clinically recommended, tumor removal may entail an undesired side effect: the risk of accelerating the growth of metastases.
Chiarella, Paula +3 more
core +1 more source
Cellular Phenotype Plasticity in Cancer Dormancy and Metastasis
Frontiers in Oncology, 2018 Cancer dormancy is a period of cancer progression in which residual tumor cells exist, but clinically remain asymptomatic for a long time, as well as resistant to conventional chemo- and radiotherapies.
Xiao Yang +4 more
doaj +1 more source
Abscisic acid regulates dormancy of prostate cancer disseminated tumor cells in the bone marrow
Neoplasia: An International Journal for Oncology Research, 2021 Prostate cancer (PCa) commonly metastasizes to the bone where the cells frequently undergo dormancy. The escape of disseminated tumor cells from cellular dormancy is a major cause of recurrence in marrow.
Younghun Jung +8 more
doaj +1 more source
Tumor Dormancy and Cell Signaling. V. Regrowth of the BCL1 Tumor After Dormancy Is Established [PDF]
Blood, 1997 AbstractThe majority of BALB/c mice immunized with the BCL1 lymphoma-derived idiotype (Id+) IgM and subsequently challenged with BCL1 tumor cells develop a state of tumor dormancy. The vast majority of dormant lymphoma cells are in cell cycle arrest, but there are also residual replicating cells.
E S, Vitetta +9 more
openaire +2 more sources
Cellular dormancy in minimal residual disease following targeted therapy
Breast Cancer Research, 2021 Background Breast cancer mortality is principally due to tumor recurrence, which can occur following extended periods of clinical remission that may last decades.
Jason R. Ruth +11 more
doaj +1 more source
The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition [PDF]
, 2016 M. tuberculosis is a facultative anaerobe and its characteristic pathological hallmark, the granuloma, exhibits hypoxia in humans and in most experimental models. Thus the host and bacillary adaptation to hypoxia is of central importance in understanding
Barry III, CE +5 more
core +1 more source
Minimal Residual Disease, Metastasis and Immunity
Biomolecules, 2021 Progression from localized to metastatic disease requires cancer cells spreading to distant organs through the bloodstream. Only a small proportion of these circulating tumor cells (CTCs) survives dissemination due to anoikis, shear forces and ...
Jordi Badia-Ramentol +3 more
doaj +1 more source
Autophagy-deficient breast cancer shows early tumor recurrence and escape from dormancy [PDF]
, 2018 Breast cancer patients who initially respond to cancer therapies often succumb to distant recurrence of the disease. It is not clear why people with the same type of breast cancer respond to treatments differently; some escape from dormancy and relapse ...
Manjili, Masoud H.
core +1 more source
Escaping Antiangiogenic Therapy: Strategies Employed by Cancer Cells [PDF]
, 2016 Indexación: Web of ScienceTumor angiogenesis is widely recognized as one of the hallmarks of cancer. Consequently, during the last decades the development and testing of commercial angiogenic inhibitors has been a central focus for both basic and ...
Carrasco-Avino, G +4 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background The management of clinically apparent single lesions or oligofocal nephroblastomatosis, a facultative precursor of nephroblastoma, remains debated. Methods We retrospectively analyzed 37 patients with clinically apparent single or oligofocal nephroblastomatosis (two to three lesions per kidney) among 2347 patients registered between
Nils Welter +17 more
wiley +1 more source