FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Inflammatory cytokines mediate the induction of and awakening from metastatic dormancy
Cell ReportsSummary: Metastases arise from disseminated cancer cells (DCCs) that detach from the primary tumor and seed distant organs. There, quiescent DCCs can survive for an extended time, a state referred to as metastatic dormancy.
Paulo Pereira +10 more
doaj +1 more source
Summer Dormancy in Perennial Cool-Season Forage Grasses
Türkiye Tarımsal Araştırmalar Dergisi, 2018 Plants survive in unfavorable environmental conditions by developing some strategies. One of these strategies is dormancy. This article was prepared to provide information about the summer dormancy of plants in summer. Summer dormancy is a type of endo-
Özlem ÖNAL AŞCI, Ömer EĞRİTAŞ
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Environment sensing in spring-dispersed seeds of a winter annual Arabidopsis influences the regulation of dormancy to align germination potential with seasonal changes [PDF]
, 2014 Seed dormancy cycling plays a crucial role in the lifecycle timing of many plants. Little is known of how the seeds respond to the soil seed bank environment following dispersal in spring into the short-term seed bank before seedling emergence in autumn.
Clay, Heather A. +3 more
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Some considerations concerning the germination and dormant period of seeds
Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 1996 The storage of dormancy or active life in seed is on their chemical composition and anatomic structure, as well on environmental factors. According to the season upon which seeds enter or are in dormancy, one can discern a primary and a secondary ...
Alexandru SALONTAI
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Development and germination of Sandersonia aurantiaca (Hook.) seeds : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Plant Biology and Biotechnology at Massey University [PDF]
, 1996 Sandersonia aurantiaca (Hook.) has recently become an important horticultural crop through its economic value for export of its cut flowers and tubers.
Zou, Xiuying
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Physiology of Chatham Island forget-me-not (Myosotidium hortensia) seed : a thesis presented in partial fulfilment of the requirements for the degree of Master of Applied Science in Seed Science and Technology at Massey University [PDF]
, 2003 Chatham Island forget-me-not (Myosotidium hortensia (Decne) Baillon) is endemic to the Chatham Islands where it is mainly confined to the outer islands. There is speculation that seed of M.
McGill, Craig Robert
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