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Tumor dormancy and immunoescape [PDF]
APMIS, 2008 The role of the immune system in tumor dormancy is now well established. In several experimental models it is possible to induce tumor dormancy in immunocompetent hosts by prior immunization against tumor cells. Equilibrium between immune response and tumor cells leads to long‐term tumor dormancy.
Bruno Quesnel, Bruno Quesnel
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Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
Horticulturae, 2023 Euphorbia maculata L. has been confirmed to have functional properties, including anticytotoxic, anti-inflammatory, and antioxidative effects. However, studies on the dormancy and germination of its seeds for cultivation purposes are lacking.
Kyungtae Park +3 more
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Breast Cancer: Targets and Therapy, 2012 Tumor dormancy describes a prolonged quiescent state in which tumor cells are present, but disease progression is not yet clinically apparent. Breast cancer is especially known for long asymptomatic periods, up to 25 years, with no evidence of the disease, followed by a relapse.
Tanja Fehm +6 more
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Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
Summer Dormancy in Perennial Cool-Season Forage Grasses
Türkiye Tarımsal Araştırmalar Dergisi, 2018 Plants survive in unfavorable environmental conditions by developing some strategies. One of these strategies is dormancy. This article was prepared to provide information about the summer dormancy of plants in summer. Summer dormancy is a type of endo-
Özlem ÖNAL AŞCI, Ömer EĞRİTAŞ
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Targeting Indoleamine 2,3-Dioxygenase 1: Fighting Cancers via Dormancy Regulation
Frontiers in Immunology, 2021 The connection between indoleamine 2,3-dioxygenase 1 (IDO1) and tumour dormancy – a quiescent state of tumour cells which has been consistently linked to metastasis and cancer recurrence – is rarely discussed despite the pivotal role of IDO1 in cancer ...
Chao Yang +5 more
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Seed germination and dormancy: The classic story, new puzzles, and evolution.
Journal of Integrative Plant Biology, 2019 This review highlights recent progresses in seed germination and dormancy research. Research on the weakening of the endosperm during germination, which is almost a classic theme in seed biology, was resumed by α-xylosidase studies.
H. Nonogaki
semanticscholar +1 more source
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Some considerations concerning the germination and dormant period of seeds
Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 1996 The storage of dormancy or active life in seed is on their chemical composition and anatomic structure, as well on environmental factors. According to the season upon which seeds enter or are in dormancy, one can discern a primary and a secondary ...
Alexandru SALONTAI
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