Results 61 to 70 of about 16,329 (248)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

CYTOLOGICAL STUDIES IN DORMANCY II. PATHOLOGICAL AGEING CHANGES DURING PROLONGED DORMANCY AND RECOVERY UPON DORMANCY RELEASE [PDF]

open access: yesNew Phytologist, 1972
SummarySeeds with a chilling requirement were maintained fully imbibed at 22–25° C for more than 6 years without germination. Similar seeds stored air‐dry at the same temperatures were dead by the second year. Cytological changes in the radicle meristem cells during the first year included the development of complex associations of ER with protein ...
openaire   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

High-concentration co-application of 2,3-Butanedione monoxime and gibberellic acid synergistically promote dormancy release and improve post-planting agronomic traits in lily bulbs

open access: yesScientia Horticulturae
Dormancy regulation is a major challenge for sustainable lily (Lilium spp.) production, as incomplete or prolonged dormancy release impacts vegetative growth and flowering.
Jinlong Li   +14 more
doaj   +1 more source

Molecular mechanism of seed dormancy release induced by fluridone compared with cod stratification in Notopterygium incisum

open access: yesBMC Plant Biology, 2018
Background Notopterygium incisum is an important Chinese medicinal plant. Its mature seeds have underdeveloped embryos and are physiological dormant.
Li Aihua   +7 more
doaj   +1 more source

Metabolomics analysis reveals Embden Meyerhof Parnas pathway activation and flavonoids accumulation during dormancy transition in tree peony

open access: yesBMC Plant Biology, 2020
Background Bud dormancy is a sophisticated strategy which plants evolve to survive in tough environments. Endodormancy is a key obstacle for anti-season culture of tree peony, and sufficient chilling exposure is an effective method to promote dormancy ...
Tao Zhang   +6 more
doaj   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

open access: yesFEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima   +7 more
wiley   +1 more source

Transcriptomic and Metabolomic Research on the Germination Process of Panax ginseng Overwintering Buds

open access: yesPlants
Ginseng (Panax ginseng C. A. Meyer) is a perennial plant with a long dormancy period. While some researchers employ gibberellin and other substances to stimulate premature germination, this method is limited to laboratory settings and cannot be applied ...
Ranqi Li   +6 more
doaj   +1 more source

SAN 9789: A Seed Dormancy Releasing Chemical

open access: yesJournal of Plant Physiology, 1985
Summary The ability of the herbicide SAN 9789 to release primary as well as different forms of secondary dormancy in lettuce seeds ( Lactuca sativa cv. Grand Rapids) was examined. Primary-, thermo-, osmo-, and far-red-dormant seeds treated with 28 μg/ml SAN 9789 in the dark at 25°C, germinated to 88, 61, 52 and 31 % respectively.
Mitrakos, K., Georghiou, K., Psaras, G.
openaire   +2 more sources

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