Results 71 to 80 of about 16,329 (248)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Medical Oxygen Concentrators for Releasing Seed Dormancy

Crop Science, 2015
ABSTRACTA new method is demonstrated for using concentrated oxygen (O2 gas) to release seed dormancy. Concentrated O2 gas in air is known to release seed dormancy in some seeds, including some foxtail (Setaria) species. New medical equipment makes O2 gas easier to work with than before, so laboratories working with dormant seeds can now use ...
Niemi, Jarad, Brenner, David, Dekker, Jack, Pfiffner, Lisa   +3 more
openaire   +3 more sources

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Effects of temperature on dormancy release in woody plants. [PDF]

Silva Fennica, 1987
Logical structure of three simulation models and one conceptual model concerning effects of temperature on dormancy release in woody plants was examined. The three basic types of simulation models differed in their underlying assumptions. Contrasting implications of the models were inferred by deduction.
openaire   +2 more sources

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Transcriptomic and Proteomic Analyses Provide Insight into Sugar Metabolism-Induced Dormancy Release of Flower Buds of Pyrus pyrifolia ‘Cuiguan’

Horticulturae
Pear buds exhibit inherent dormancy, during which carbohydrates play a pivotal role in dormancy release and germination. In this study, Pyrus pyrifolia ‘Cuiguan’ was employed as the experimental material to investigate the molecular mechanisms underlying
Huiquan Wang, Ling Ding, Qinghua Ye, Xueying Huang, Lei Xu, Shaohua Wu, Dongjin He   +6 more
doaj   +1 more source

Comparative transcriptomic analysis reveals genes regulating the germination of morphophysiologically dormant Paris polyphylla seeds during a warm stratification.

PLoS ONE, 2019
We previously analyzed the expression of genes associated with Paris polyphylla var. yunnanensis seed maturation and dormancy release; however, we were unable to clarify the relationship between gene expression levels and these processes.
Dengqun Liao, Juan Zhu, Menghuan Zhang, Xian'en Li, Peng Sun, Jianhe Wei, Jianjun Qi   +6 more
doaj   +1 more source

Transcriptome Analysis of Seed in Dormancy and Dormancy Release State of Epimedium koreanum Nakai

Agronomy
Epimedium koreanum is a perennial herb of the Berberidaceae family, which is a traditional tonic in Chinese medicine. Seed germination of E. koreanum is difficult. Dormancy is an intrinsic factor that affects seed germination. Elucidating the molecular mechanism of seed dormancy and the lifting process of E.
Zhang, Yonggang, Wu, Feng, Yu, Jingjing, Zhang, Zhiqiang, Huang, Xiangdi, Hou, Huiling, Yang, Limin   +6 more
openaire   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Isolation and Role of PmRGL2 in GA-mediated Floral Bud Dormancy Release in Japanese Apricot (Prunus mume Siebold et Zucc.)

Frontiers in Plant Science, 2018
Bud dormancy release is regulated by gibberellins (GAs). DELLA proteins are highly conserved and act as negative regulators in GA signaling pathway. The present study established a relationship between PmRGL2 in Japanese apricot and GA4 levels during ...
Lin Lv, Ximei Huo, Luhua Wen, Zhihong Gao, Muhammad Khalil-ur-Rehman   +4 more
doaj   +1 more source