Results 91 to 100 of about 1,233,920 (254)

Transmission electron micrographs: dorsal root ganglia

, 2023
Transmission electron micrographs of dorsal root ganglia neurons associated with  Pocratsky et al 2023, Science Translational Medicine  TEM_DRG_metaData.xlsx: summary spreadsheet of raw images provided including codes for genotypes Images were ...
Amanda Pocratsky (6782732), Marco Beato (6771347), Gorkem Ozyurt (7407341), Rob Brownstone (6777962), Roisin Sullivan (7102346), Sunaina Surana (6766286), Benjamin O'Callaghan (7083359), Calvin Smith (6778394), Filipe Do Nascimento Xavier Fernandes (6779813), Ian White (10241246)   +9 more
core   +1 more source

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

Advanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng, Xiaqing Lin, Hongyu Yao, Cheng Li, Huabao Liao, Yuexin Liu, Boxu Cao, Xue‑Jun Song   +7 more
wiley   +1 more source

Axonal sprouting from adjacent dorsal root ganglia following cervical dorsal root avulsion in mice

Neuroscience Research
Brachial plexus injury is a neurological injury caused by trauma, and effective treatments remain limited. Understanding its pathology is necessary to develop new therapeutic strategies.
Gaku Kanemoto, Takahide Itokazu, Toru Nakanishi, Takeru Furumiya, Seiji Okada, Toshihide Yamashita   +5 more
doaj   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3

Annals of Neurology, EarlyView.
Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato, John M. Hayes, Jacen Emerson, Maeha Sridharan, Toluwani Adelaja, Arsal Naeem, Alexandra F. Putka, Hayley S. McLoughlin   +7 more
wiley   +1 more source

Herpes Simplex Virus Type 1 Human Cervical Dorsal Root Ganglionitis

Case Reports in Neurology, 2017
We present a case of a 34-year-old right-handed Caucasian male with chronic occipital neuralgia refractory to medical therapies and minimally invasive pain procedures who underwent surgical cervical dorsal root ganglionectomy which completely relieved ...
Tibor Valyi-Nagy, Jaivir S. Rathore, Andrei M. Rakic, Ranvir S. Rathore, Paavani Jain, Konstantin V. Slavin   +5 more
doaj   +1 more source

Circulating Exosomes Drive Persistent Neuronal Dysfunction in Post‐Herpetic Neuralgia Patients

Annals of Neurology, EarlyView.
Proposed model of exosome‐mediated neuronal dysfunction in post‐herpetic neuralgia (PHN). (1) Circulating, non‐pathogenic exosomes maintain homeostatic processes in healthy skin, where sensory nerve fibers innervate the epidermis and dermis. (2) During acute zoster, reactivating varicella zoster virus (VZV) travels down neurites to the skin causing ...
Christy S. Niemeyer, Seth Frietze, Serena W.R. Lewis, Emily C. Artman, Christina Coughlan, Safa I. Vaseemuddin, Arianna Gentile Polese, Maria A. Nagel, Stephen K. Tyring, Fyona Okundia, Anthony J. Saviola, Gary C. Curhan, Sharon G. Curhan, Diego Restrepo, Andrew N. Bubak   +14 more
wiley   +1 more source

Gene expression changes in dorsal root ganglia following peripheral nerve injury: roles in inflammation, cell death and nociception

Neural Regeneration Research, 2019
Subsequent to a peripheral nerve injury, there are changes in gene expression within the dorsal root ganglia in response to the damage. This review selects factors which are well-known to be vital for inflammation, cell death and nociception, and ...
Sarah L Martin, Adam J Reid, Alexei Verkhratsky, Valerio Magnaghi, Alessandro Faroni   +4 more
doaj   +1 more source

Brain tissue properties differentiate between motor and limbic basal ganglia circuits [PDF]

, 2014
Despite advances in understanding basic organizational principles of the human basal ganglia, accurate in vivo assessment of their anatomical properties is essential to improve early diagnosis in disorders with corticosubcortical pathology and optimize ...
Haynes, J., Weiskopf, N, Ettore A. Accolla, Dukart, J., Kherif, Ferath, Weiskopf, N. ; https://orcid.org/, Kuehn, Andrea A., Helms, Gunther, Gunther Helms, Weiskopf, Nikolaus, Rumana Chowdhury, John‐Dylan Haynes, Chowdhury, R., Dukart, Jürgen, Draganski, Bogdan, Stefan Hetzer, Hetzer, S, Kühn, Andrea A., Draganski, B. ; https://orcid.org/, Accolla, E., Haynes, John-Dylan, Ferath Kherif, Juergen Dukart, Kühn, AA, Accolla, Ettore A., Chowdhury, R, Andrea A. Kühn, Dukart, Juergen, Chowdhury, Rumana, Hetzer, Stefan, Antoine Lutti, Hetzer, S., Lutti, Antoine, Accolla, EA, Draganski, B, Helms, Gunther,, Nikolaus Weiskopf, Kühn, A., Bogdan Draganski, Kherif, F., Kherif, F, Helms, G., Helms, G, Lutti, A, Lutti, A., Lund University., Dukart, J, Haynes, J-D   +47 more
core   +1 more source

Reframing the Gut–Brain Axis: The Gut Wall as a Neural Immune Interface in Multiple Sclerosis and Autoimmune Neurological Diseases

Annals of Neurology, EarlyView.
Gut wall physiology in multiple sclerosis (MS) and autoimmune neurologic diseases remains underexplored but may span gut barrier dysfunction, enteric glial targeting, mucosal immune dysregulation, and autoimmune targets within the enteric nervous system (ENS).
Federico Montini, Sean J. Pittock, Laura Cacciaguerra, Howard L. Weiner, Luke A. Schwerdtfeger   +4 more
wiley   +1 more source