Results 191 to 200 of about 523,044 (279)

Genome Aging in Women: Hematopoietic Loss of X Chromosome as An Exemplar

open access: yesAging Cell, Volume 25, Issue 11, November 2026.
As studies at the intersection of genetics and aging are rapidly advancing, genome aging provides a novel mechanism by which aging phenotypes occur. In this Review, the authors examine the rise, expansion, and the consequences of X chromosome loss in female blood cells.
Xihan Guo, Xueqin Dai
wiley   +1 more source

Neural focalization of dorsolateral prefrontal cortex and the inferior parietal lobule is associated with inhibitory control performance in adolescence. [PDF]

open access: yesDev Cogn Neurosci
Meredith WJ   +8 more
europepmc   +1 more source

Lysergic Acid Diethylamide Induces Transcriptional Changes Opposing Signatures of Brain Ageing and Neurodegeneration

open access: yesAging Cell, Volume 25, Issue 11, November 2026.
Lysergic acid diethylamide (LSD) induces transcriptional programmes in the rodent prefrontal cortex that oppose signatures of human brain ageing and neurodegeneration. In primary cortical cultures, LSD also attenuates amyloid‐β‐induced alterations. Consistent with the signature reversion principle, these findings provide a data‐driven rationale for ...
Aurora Savino   +9 more
wiley   +1 more source

Uncovering the signatures of aging and senescence in the human dorsolateral prefrontal cortex. [PDF]

open access: yesCell Genom
Sloan NX   +25 more
europepmc   +1 more source

GABAergic Network Dysregulation in Alcohol Use Disorder: Receptor–Transporter Interactions Driving the Transition From Goal‐Directed to Compulsive Behaviour

open access: yesAddiction Biology, Volume 31, Issue 11, November 2026.
Astrocytic GAT3 regulates ambient GABA levels in the globus pallidus externus (GPe). Reduced GAT3 function enhances extrasynaptic GABAergic signalling and disrupts subthalamic nucleus (STN) regulation and cortical signal fidelity.ABSTRACTAlcohol use disorder (AUD) is characterized by a shift from controlled, goal‐directed drinking to compulsive ...
Hannah Aranda   +3 more
wiley   +1 more source

Physiological Arousal During Alcohol Cue Exposure in Adult Drinkers: Sex Differences in Neural and Clinical Correlates

open access: yesAddiction Biology, Volume 31, Issue 11, November 2026.
In 94 adult drinkers, females exhibited greater physiological arousal to ‘alcohol〉neutral’ cues, but only males showed positive associations between cue‐evoked arousal and alcohol expectancy, novelty seeking, pgACC response and problem drinking severity.
Yu Chen   +5 more
wiley   +1 more source

The developmental trajectories of working memory updating from early childhood to adolescence: A meta‐analysis

open access: yesBritish Journal of Psychology, Volume 117, Issue 4, Page 1367-1395, November 2026.
Abstract Working memory updating is a crucial cognitive function for learning and academic achievement that develops significantly throughout childhood and adolescence. Despite the varieties of existing tasks to measure children's working memory updating, its overall developmental trajectory and task‐specific developmental patterns remain inadequately ...
Ye Song, Chen Cheng
wiley   +1 more source

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