Results 51 to 60 of about 402,447 (218)

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Temporal‐Targeted Accelerated 40 Hz tACS Enhances Cognitive Function and Network Integration in Alzheimer's Disease: A Randomized Clinical Trial

Advanced Science, EarlyView.
Bilateral temporal accelerated 40‐Hz tACS improves cognitive function in patients with Alzheimer's disease. Resting‐state fNIRS identifies treatment‐related increases in frontotemporoparietal functional connectivity, which are associated with cognitive improvement. ABSTRACT The temporal lobes are key hubs for memory and cognition.
Rong Guo, Xingxing Li, Chenjun Zou, Chao Zheng, Xiaohong Wu, Xuechao Lu, Jiaying Yan, Junfang Zhang, Xiaoyan Luo, Shiwei Ye, Dongsheng Zhou   +10 more
wiley   +1 more source

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

Creativity and its link to epilepsy

Epilepsia Open, EarlyView.
Abstract Creative thinking represents one of our highest‐order cognitive processes, involving multiple cortical structures and an intricate interplay between several cortical and subcortical networks. It results in novel ideas that translate to useful products or concepts. The evolutionary purpose of creativity is therefore apparent, as it advances our
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Integration of auditory and visual communication information in the primate ventrolateral prefrontal cortex [PDF]

, 2006
The integration of auditory and visual stimuli is crucial for recognizing objects, communicating effectively, and navigating through our complex world.
Tadashi Sugihara, Mark D. Diltz, Sugihara, T, Averbeck, BB, Romanski, LM, Lizabeth M. Romanski, Diltz, MD, Bruno B. Averbeck   +7 more
core  

Effects of Low Frequency Prefrontal Repetitive Transcranial Magnetic Stimulation on the N2 Amplitude in a GoNogo Task. [PDF]

PLoS ONE, 2013
During the last decade, repetitive transcranial magnetic stimulation (rTMS) of the prefrontal cortex has become established as a treatment for various mental diseases.
Nicola Grossheinrich, Maren Reinl, Oliver Pogarell, Susanne Karch, Christoph Mulert, Monika Brueckl, Kristina Hennig-Fast, Anne Rau, Maria Epple, Ariane Hornig, Frank Padberg   +10 more
doaj   +1 more source

Transcriptional signatures of cortical morphometric variability in temporal lobe epilepsy

Epilepsia Open, EarlyView.
Abstract Objective Widespread cognitive deficits in temporal lobe epilepsy (TLE) are associated with macroscale brain structural changes. However, the correlation between the changes in the cortical morphological similarity of the TLE and gene expression remains unclear.
Yaping Dong, Shuai Wang, Jingjie Luo, Juan Meng, Yuanmei Liu, Song Zhang   +5 more
wiley   +1 more source

Identifiable regional and neural network abnormalities in early childhood anxiety

JCPP Advances, EarlyView.
Abstract Background Although the neural underpinnings of anxiety have been investigated, most research has been confined to adolescence and adulthood, with less of a focus on the early childhood period. Little is known about the role of anticipatory fear processing early childhood, which is a sensitive period for anxiety development.
Khalil I. Thompson, Yiwen Zhang, Denny Schaedig, Anna Bankston, Anoushka Parnerkar, Shrinidhi Jeyaram, Nadine Melhem, Susan B. Perlman   +7 more
wiley   +1 more source

Model-Based Decision Making in the Human Brain [PDF]

, 2007
Many real-life decision making problems incorporate higher-order structure, involving interdependencies between different stimuli, actions, and subsequent rewards.
Hampton, Alan Nicolás
core   +1 more source

Transcranial direct current stimulation (tDCS) improves emotion regulation in children with attention-deficit hyperactivity disorder (ADHD)

Scientific Reports
Children with attention deficit/hyperactivity disorder (ADHD) typically exhibit difficulties in emotion regulation. It has been shown that the dorsolateral prefrontal cortex (dlPFC) and ventromedial prefrontal cortex (vmPFC) are crucially involved in ...
Reza Estaji, Mariam Hosseinzadeh, Fariba Arabgol, Vahid Nejati   +3 more
doaj   +1 more source