Results 81 to 90 of about 402,447 (218)

The neural correlates of optimistic and depressive tendencies of self-evaluations and resting-state default mode network

open access: yesFrontiers in Human Neuroscience, 2015
: Unrealistic optimism is common among people making self-evaluations while reduced optimism has been linked to increased depressive symptoms. Given the importance of optimism for adaptive functioning, surprisingly little is known about resting brain ...
Jinfeng eWu   +5 more
doaj   +1 more source

Using e-greedy reinforcement learning methods to further understand ventromedial prefrontal patients' deficits on the Iowa Gambling Task [PDF]

open access: yes, 2005
An important component of decision making is the process of choosing from a set of options. This choice is often based on an evaluation of the potential costs or benefits of selecting an option, its estimated reward value.
Kalidindi, Kiran   +2 more
core  

Modulating Activity in the Prefrontal Cortex Changes Intertemporal Choice for Loss: A Transcranial Direct Current Stimulation Study

open access: yesFrontiers in Human Neuroscience, 2019
Intertemporal choice refers to decisions involving tradeoffs between costs and benefits occurring at different times. Studies have found that weighting the time and benefits during decision-making involves a complex neural network that includes the ...
Guanxing Xiong   +11 more
doaj   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

open access: yesObesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey   +7 more
wiley   +1 more source

Acute Psychological Stress Reduces Working Memory-Related Activity in the Dorsolateral Prefrontal Cortex

open access: yes, 2009
Background: Acute psychological stress impairs higher-order cognitive function such as working memory (WM). Similar impairments are seen in various psychiatric disorders that are associated with higher susceptibility to stress and with prefrontal ...
Fernandez, Guillen   +4 more
core   +1 more source

Distinct Neural Circuits Underlie Prospective and Concurrent Memory-Guided Behavior

open access: yesCell Reports, 2019
Summary: The past is the best predictor of the future. This simple postulate belies the complex neurobiological mechanisms that facilitate an individual’s use of memory to guide decisions. Previous research has shown integration of memories bias decision-
Amanda G. Hamm, Aaron T. Mattfeld
doaj   +1 more source

Temporal Interference Modulates Medial Temporal and Frontoparietal Activity During Mnemonic Discrimination: A High‐Resolution Whole‐Brain fMRI Investigation

open access: yesHippocampus, Volume 36, Issue 6, November 2026.
ABSTRACT Mnemonic discrimination—the ability to distinguish between existing memories and similar new inputs—supports accurate memory in the face of interference (e.g., in a card game, recognizing that the card you are currently seeing, the King of Hearts, is distinct from the King of Diamonds you encountered earlier in the same hand).
Min Sung Seo   +4 more
wiley   +1 more source

Anterior cingulate cortex-related connectivity in first-episode schizophrenia: a spectral dynamic causal modeling study with functional magnetic resonance imaging

open access: yesFrontiers in Human Neuroscience, 2015
Understanding the neural basis of schizophrenia (SZ) is important for shedding light on the neurobiological mechanisms underlying this mental disorder. Structural and functional alterations in the anterior cingulate cortex (ACC), dorsolateral prefrontal ...
Long-Biao eCui   +12 more
doaj   +1 more source

Cell‐based polygenic risk scores predict clinical progression and prioritize network‐based therapeutic targets in Alzheimer's disease

open access: yesAlzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract BACKGROUND Late‐onset Alzheimer's disease (AD) exhibits substantial biological heterogeneity. We developed a framework linking cell‐type–specific polygenic risk profiles to precision medicine in AD. METHODS Cell‐based polygenic risk scores (cbPRSs) derived from single‐nucleus RNA‐seq co‐expression networks were evaluated in Alzheimer's Disease
Nathan Sahelijo   +16 more
wiley   +1 more source

Repetitive Transcranial Magnetic Stimulation Combined With Median Nerve Electrical Stimulation for Severe Traumatic Brain Injury

open access: yesBrain and Behavior, Volume 16, Issue 10, October 2026.
Combining top‐down rTMS over the left DLPFC with bottom‐up right median nerve stimulation markedly outperformed either modality alone, awakening 93% of patients with severe TBI by week 4 and improving EEG, hemodynamics, and GCS—supporting dual‐pathway neuromodulation as a safe, high‐efficacy strategy for coma recovery.
Nana Wang, Manrong Li, Guozhen Zhang
wiley   +1 more source

Home - About - Disclaimer - Privacy