Results 71 to 80 of about 29,170 (291)
Advanced Science, EarlyView.A developmentally guided protocol reproducibly specifies EN1‐positive ventral midbrain dopaminergic (vmDA) progenitors from human pluripotent stem cells and yields functional vmDA neurons. Optogenetic induction of α‐synuclein aggregation elicits selective degeneration of TH‐positive neurons in 2D cultures and 3D neurospheroids, while transplanted ...
Heechang Moon +12 more
wiley +1 more source
, 2008 FIGURES 1–6. 1–4. Myrsidea lightae. 1. Female dorsoventral metathorax and abdomen. 2. Male genitalia. 3. Male genital sac sclerite. 4. Male dorsoventral metathorax and abdomen. 5–6. M. johnklickai. 5. Female dorsoventral metathorax and abdomen. 6.
Dalgleish, Robert C. +2 more
core +1 more source
DmMyD88 controls dorsoventral patterning of the Drosophila embryo [PDF]
The EMBO Reports, 2003 MyD88 is an adapter protein in the signal transduction pathway mediated by interleukin-1 (IL-1) and Toll-like receptors. A Drosophila homologue of MyD88 (DmMyD88) was recently shown to be required for the Toll-mediated immune response. In Drosophila, the Toll pathway was originally characterized for its role in the dorsoventral patterning of the embryo.
Kambris, Zakaria +5 more
openaire +3 more sources
Advanced Science, EarlyView.Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan +12 more
wiley +1 more source
in dorsoventral pattern formation
, 2000 International audienceABSTRACT A bone morphogenetic protein (BMP) signaling pathway acts in the establishment of the dorsoventral axis of the vertebrate embryo.
Stephanie A. Connors +13 more
core +1 more source
Microsurgical and laser ablation analysis of leaf positioning and dorsoventral patterning in tomato [PDF]
, 2004 Leaves are arranged according to regular patterns, a phenomenon referred to as phyllotaxis. Important determinants of phyllotaxis are the divergence angle between successive leaves, and the size of the leaves relative to the shoot axis.
Martin Frenz +11 more
core +2 more sources
A UBE3A‐UTX Proteostasis‐Epigenetic Axis Governs Hypothalamic Energy Homeostasis
Advanced Science, EarlyView.Ubiquitin protein ligase E3A (UBE3A) regulates hypothalamic energy homeostasis and promotes degradation of the histone demethylase UTX (KDM6A). Neuronal UBE3A loss increases susceptibility to diet‐induced obesity and is accompanied by UTX accumulation, reduced histone H3 lysine 27 trimethylation, and altered endoplasmic reticulum stress‐responsive gene
Junekyoung Lee +7 more
wiley +1 more source
Implications for dorsoventral axis determination from the zebrafish mutation janus
, 1994 THE mechanisms underlying the formation of dorsoventral polarity in the zebrafish Danio rerio are unknown. Here we describe the zebrafish recessive maternal-effect mutation janusm55.
Driever, Wolfgang +11 more
core +1 more source
Advanced Electronic Materials, EarlyView.In this study, we developed a cost‐efficient neural probe by replacing traditional gold with an aluminum‐based Ti/Al/Ni multilayer stack. Optimizing this metal architecture suppressed oxidation and ensured robust electrical stability, achieving signal quality comparable to standard gold probes. It enables a highly accessible and economical solution for
Sehwan Park +6 more
wiley +1 more source