Results 121 to 130 of about 10,254,775 (266)

Rastreio do cancro do colo do útero dos açores – A mudança do paradigma

, 2023
O programa de Rastreio Organizado do Cancro do Colo do Útero dos Açores (ROCCA) está implementado desde 2010 com o objetivo de diagnosticar precocemente lesões precursoras de malignidade e carcinoma invasivo. A metodologia primária de rastreio utilizada nos três primeiros ciclos do ROCCA foi a citologia líquida, e a partir do quarto ciclo, desde 2021 ...
Maciel, Débora, Fernandes, Sílvia, Silva, Regina A.   +2 more
openaire   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tendinite em equinos atletas

Pubvet
A tendinite é uma afecção de considerável importância em equinos, especialmente naqueles utilizados em atividades esportivas, como o hipismo (salto), por causar significativas perdas econômicas e impactos no bem-estar animal.
Angela Rosa Tassoni, Eduarda Finger Maciel, Guilherme Ribeiro, Gustavo Silveira Franzoni da Silva, Naiza Eduarda Grevinell Padilha, Sofia Schuler de Fraga , Ilusca Finger   +6 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Projeto ONCO: preparo odontológico para pacientes portadores de neoplasias malignas

Revista Ciência em Extensão, 2011
Introdução: É esperado que pacientes com câncer desenvolvam algum tipo de complicação na região oral, que pode estar relacionada às condições de saúde bucal do paciente e ao tipo de terapia utilizada.
Vivian Narana Ribeiro El Achkar, Emanuel Rovai, Érica Crastechini, Fernando Vagner Raldi, Lúcio Murilo dos Santos, Maria Filomena R. Lima Huhtala, Rodrigo Dias Nascimento, Rosana Ferreira Silva, Rosemary Soares Santana, Warley David Kerbauy   +9 more
doaj  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Manejo quirúrgico del angiofibroma nasofaríngeo juvenil

Anales de la Facultad de Medicina, 2007
Objetivos: Describir el manejo quirúrgico del angiofibroma nasofaríngeo juvenil, tanto en el abordaje como en la anestesia, evidenciar el grado de compromiso y estadio de los casos intervenidos y determinar las complicaciones y recurrencias del ...
Juan Oré, José Saavedra, Ladislao Pasache, Roberto Iwaki, Francisco Avello, Johnny Cárdenas   +5 more
doaj  

Dos Mundos: A Communicative Approach [PDF]

, 1989
Gardiol, Rita
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source