Results 111 to 120 of about 10,254,775 (266)

Hepatitis in Dengue Shock Syndrome

Brazilian Journal of Infectious Diseases
Dengue fever is the most frequent arbovirus disease in the world and the most important one in terms of morbidity and mortality. Atypical manifestations of dengue have become commonplace during the last few years, including hepatic damage, which ...
Luiz José de Souza, Helder Gonçalves Carneiro, João Tadeu Damian Souto Filho, Thiago Ferreira de Souza, Vitor Azevedo Côrtes, Carlos Gicovate Neto, Diogo Assed Bastos, Edno Wallace da Silva Siqueira   +7 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Acúmulo de nutrientes na parte aérea do pinhão-manso em duas condições edafoclimáticas

Semina: Ciências Agrárias, 2018
Com a possibilidade de utilização do óleo do pinhão-manso como uma alternativa energética, tem-se a necessidade de realizar estudos referentes à absorção e acúmulo de nutrientes nas diferentes fases de desenvolvimento da cultura para manejo adequado da ...
Sávio Coelho Magalhães, Enilson de Barros Silva, Evander Alves Ferreira, Thassio de Menezes Reis, Gustavo Antônio Mendes Pereira, Filipe Vieira Araújo, Tânia Pires da Silva   +6 more
doaj  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Avaliação da progressão cognitiva no internato de clínica médica

Revista Brasileira de Educação Médica
Este artigo investiga o crescimento cognitivo de estudantes de Medicina durante o internato de Clínica Médica do Centro Universitário Serra dos Órgãos, de janeiro de 1999 a dezembro de 2004.
Sávio Silva Santos, Rodrigo Siqueira-Batista, Andréia Patrícia Gomes, Loriléa Chaves de Almeida, Lúcia Brandão de Oliveira, Rodolpho Jacques M. Farinazzo, Sérgio Pettendorfer, Luiz Felipe da Silva Pinto   +7 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

DoS‐a‐DoS

Eos, Transactions American Geophysical Union, 1995
When it comes to creating a Department of Science (DoS), House Science Committee chair Robert Walker (R‐Pa.) says he is “not looking to create a science dictator here.” Although the details of the new bill are still being ironed out, Walker says the agency, as a singular cabinet agency, would house the National Science Foundation, NASA, the ...
openaire   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Vacinação contra influenza e pneumococo na insuficiência cardíaca: uma recomendação pouco aplicada

Arquivos Brasileiros de Cardiologia, 2011
FUNDAMENTO: A insuficiência cardíaca (IC) cursa com frequentes descompensações e admissões ao serviço de emergência. Vacinação contra Influenza (INF) e Pneumococo (PNM) são recomendadas nas diretrizes, entretanto, as infecções respiratórias são a ...
Wolney de Andrade Martins, Margarete Domingues Ribeiro, Lucia Brandão de Oliveira, Luciana da Silva Nogueira de Barros, Ana Cristina da Silva Moreira Jorge, Camila Mirante dos Santos, Daniella de Paiva Almeida, Isaías Fiuza Cabral, Renata Tavares de Souza, Thyago Antônio Biagioni Furquim   +9 more
doaj