Results 151 to 160 of about 7,158,818 (312)

Vacinação contra influenza e pneumococo na insuficiência cardíaca: uma recomendação pouco aplicada

Arquivos Brasileiros de Cardiologia, 2011
FUNDAMENTO: A insuficiência cardíaca (IC) cursa com frequentes descompensações e admissões ao serviço de emergência. Vacinação contra Influenza (INF) e Pneumococo (PNM) são recomendadas nas diretrizes, entretanto, as infecções respiratórias são a ...
Wolney de Andrade Martins, Margarete Domingues Ribeiro, Lucia Brandão de Oliveira, Luciana da Silva Nogueira de Barros, Ana Cristina da Silva Moreira Jorge, Camila Mirante dos Santos, Daniella de Paiva Almeida, Isaías Fiuza Cabral, Renata Tavares de Souza, Thyago Antônio Biagioni Furquim   +9 more
doaj  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Distribuição dos moluscos terrestres da ilha do Pico (Açores) e variabilidade de Oxychilus (Droutia) minor (Morelet, 1860) [PDF]

, 2006
XII Expedição Científica do Departamento de Biologia - Pico 2005.Os moluscos terrestres da ilha do Pico têm sido objecto de estudos vários, mas sobre eles de facto pouco se tem publicado.
Melo, Paulo Jorge, Martins, António M. de Frias, Cunha, Regina Tristão da, Sousa, Maria Helena S.   +3 more
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Manejo quirúrgico del angiofibroma nasofaríngeo juvenil

Anales de la Facultad de Medicina, 2007
Objetivos: Describir el manejo quirúrgico del angiofibroma nasofaríngeo juvenil, tanto en el abordaje como en la anestesia, evidenciar el grado de compromiso y estadio de los casos intervenidos y determinar las complicaciones y recurrencias del ...
Juan Oré, José Saavedra, Ladislao Pasache, Roberto Iwaki, Francisco Avello, Johnny Cárdenas   +5 more
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Functional Capacity as a Correlate of Health-Related Quality of Life in Patients With Heart Failure: A Cross-Sectional Study. [PDF]

Nurs Health Sci
Dos Santos JAG, de Oliveira Mangueira S, Santos VB, Juárez-Vela R, Cabral JVB, de Sousa MM.   +5 more
europepmc   +1 more source