Results 111 to 120 of about 653,512 (354)
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Effect of Bio-phosphate on Increasing the Phosphorus Availability, the Growth and the Yield of Lowland Rice in Ultisol [PDF]
, 2010 Effects of Bio-phosphate on Increasing the Phosphorus Availability, the Growth and the Yield of Lowland Rice in Ultisol (Yafizham and M Abubakar): Ultisol soil is low of macro and micro nutrient, pH and base saturation as well as high toxicity of Al ...
Abubakar, Muslim, Yafizham, Yafizham
core +1 more source
Neuroprotective effect and preparation methods of berberine
Frontiers in PharmacologyBerberine (BBR) is a natural alkaloid, which has played an important role in the field of medicine since its discovery in the late 19th century. However, the low availability of BBR in vivo prevents its full effect.
Yi-Xuan Sunhe +4 more
doaj +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
The Effect of Silica Surface Area on Microparticle Retention Systems [PDF]
, 1997 Retention of fines and fillers has always been a concern in the paper industry. There has been many different types of retention aids in the past, but they lack performance under the vigorous conditions in today\u27s paper mills.
Hoffmann, Jason P.
core +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
A critical comparison between dosage forms in traditional Persian pharmacy and those reported in current pharmaceutical sciences [PDF]
Research Journal of Pharmacognosy, 2017 There were many natural pharmaceutical dosage forms cited by Persian pharmacists and physicians in the historical pharmacopeias (Qarabadins). This work aimed to perform a comprehensive study on “Qarābādin-e-Sālehi” (1765 A.D.), one of the main Persian ...
M. Baranifard +4 more
doaj
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
DETERMINATION OF ANTAZOLINE IN DOSAGE FORMS AND WITH NAPHAZOLINE IN COMBINATION [PDF]
, 1984 S. El-Shabouri +3 more
openalex +1 more source
Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source