Results 181 to 190 of about 11,911,230 (418)

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

The second peak in the serum levels curve after oral administration of a slow‐release quinidine dosage form: effect of food [letter] [PDF]

, 1982
Jean Spénard, G Sirois, Ma Hew Gagnon
openalex   +1 more source

TASTE MASKED ORODISPERSIBLE TABLETS: A HIGHLY PATIENT COMPLAINT DOSAGE FORM [PDF]

, 2016
Objective: Tablet is still most popular conventional dosage forms existing today, but the drawback of solid dosage forms is the difficulty in swallowing(dysphagia) or chewing in some patients particularly pediatric and geriatric patients. For this reason,
Singh, Shivangi, Verma, Navneet
core   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

FORMULATION AND CHARACTERIZATION OF CARVEDILOL NANOEMULSION ORAL LIQUID DOSAGE FORM [PDF]

, 2015
Objective: Carvedilol is antihypertensive. It is practically water insoluble. Therefore, the objective of this investigation is a formulation and characterization of carvedilol nano emulsion (NE) employing orally to increase carvedilol solubility for ...
Drais, Hayder Kadhim, Hussein, Ahmed Abbas   +1 more
core  

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source

Commercial Chinese polyherbal preparation: current status and future perspectives

Frontiers in Pharmacology
ObjectiveWith the modernization of traditional Chinese medicine (TCM) industry, the investment in research and development of new commercial Chinese polyherbal preparations (CCPPs) is increasing, and the varieties of CCPPs are growing.
Zhang Chenyao, Hu Haiyin, Shi Menglong, Ma Yucong, Alice Josephine Fauci, Alice Josephine Fauci, Myeong Soo Lee, Wu Xiaolei, Zhang Junhua, Ji Zhaochen, Ji Zhaochen, Ji Zhaochen   +11 more
doaj   +1 more source

Development of a Dosage form for a Photoswitchable Local Anesthetic Ethercaine. [PDF]

Pharmaceuticals (Basel), 2023
Noev A, Morozova N, Suvorov N, Vasil'ev Y, Pankratov A, Grin M.   +5 more
europepmc   +1 more source

Performance Characteristics of Methods of Analysis Used for Regulatory Purposes. I. Drug Dosage Forms. F. Gravimetric and Titrimetric Methods [PDF]

, 1988
Michel Margosis, William Horwitz, Richard H Albert   +2 more
openalex   +1 more source

Gel Dosage Form

Definitions, 2020

semanticscholar   +1 more source