Results 51 to 60 of about 11,911,230 (418)
Reliable Off-Policy Learning for Dosage Combinations [PDF]
arXiv, 2023 Decision-making in personalized medicine such as cancer therapy or critical care must often make choices for dosage combinations, i.e., multiple continuous treatments. Existing work for this task has modeled the effect of multiple treatments independently, while estimating the joint effect has received little attention but comes with non-trivial ...
arxiv
NOVEL PHARMACEUTICAL DOSAGE FORM [PDF]
, 2018 Objective of the proposed idea is to introduce novel pharmaceutical dosage form prepared of biodegradable polymeric balls. These polymeric balls will encircle oral liquid dosage forms within an edible membrane which can be flavoured, coloured, and can be
Maheshwari, RK, Padiyar, A
core +2 more sources
Multicomponent crystals: Solubility enhancement of simvastatin using arginine and glycine coformers [PDF]
Journal of Pharmacy & Pharmacognosy ResearchContext: Simvastatin can be modified by the formation of multicomponent crystals to increase its solubility. Aims: To compare the solubility of multicomponent simvastatin crystals to pure simvastatin. Methods: The in silico study of simvastatin and
Iyan Sopyan +3 more
doaj +1 more source
Using Limited Trial Evidence to Credibly Choose Treatment Dosage when Efficacy and Adverse Effects Weakly Increase with Dose [PDF]
arXiv, 2023 In medical treatment and elsewhere, it has become standard to base treatment intensity (dosage) on evidence in randomized trials. Yet it has been rare to study how outcomes vary with dosage. In trials to obtain drug approval, the norm has been to specify some dose of a new drug and compare it with an established therapy or placebo.
arxiv
A Preformulation of a Water Soluble Furosemide Dosage Form [PDF]
, 2005 Solid dispersion system of water-insoluble furosemide in polyvinylpirolidon (PVP) was prepared by a solvent method in various ratios of 1 : 1, 1 : 3, 1 : 5, 1 : 7 and 1 : 9 of the drug and PVP, respectively in order to improve furosemide solubility and ...
Hakim, Lukman +2 more
core +2 more sources
Pharmaceutics, 2023 Posterior capsule opacification (PCO) remains the most common cause of vision loss post cataract surgery. The clinical management of PCO formation is limited to either physical impedance of residual lens epithelial cells (LECs) by implantation of ...
Xinyang Li +7 more
doaj +1 more source
LIQUISOLID TECHNIQUE: A NOVEL APPROACH FOR DOSAGE FORM DESIGN [PDF]
, 2017 The liquisolid technique is a novel approach for delivery of drugs through the oral route. This technique is suitable for poorly soluble or water insoluble drugs, highly permeable drugs (BCS Class II drugs) and also for immediate or sustained release ...
Panda, Satyajit +3 more
core +2 more sources
mAbsHighly concentrated antibody solutions are necessary for developing subcutaneous injections but often exhibit high viscosities, posing challenges in antibody-drug development, manufacturing, and administration.
Lateefat A. Kalejaye +19 more
doaj +1 more source
Andrographis paniculata Dosage Forms and Advances in Nanoparticulate Delivery Systems: An Overview
Molecules, 2022 Andrographis paniculata is a well-known Asian medicinal plant with a major phytoconstituent of diterpene lactones, such as andrographolide, 14-deoxyandrographolide, and neoandrographolide. A World Health Organization (WHO) monograph on selected medicinal
Subashini Raman +2 more
doaj +1 more source
Scheduling Dosage of Proton Pump Inhibitors Using Constrained Optimization With Gastric Acid Secretion Model [PDF]
arXiv, 2023 Dosage schedule of the Proton Pump Inhibitors (PPIs) is critical for gastric acid disorder treatment. In this paper, we develop a constrained optimization based approach for scheduling the PPIs dosage. In particular, we exploit a mathematical prediction model describing the gastric acid secretion, and use it within the optimization algorithm to predict
arxiv