Results 61 to 70 of about 11,911,230 (418)
Enabling modular dosage form concepts for individualized multidrug therapy: Expanding the design window for poorly water-soluble drugs [PDF]
, 2021 Multidrug dosage forms (aka combination dosage forms, polypills, etc.) create value for patients through reduced pill burdens and simplified administration to improve adherence to therapy.
Abrahms\ue9n-Alami, Susanna +4 more
core +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Tocotrienols In Solid Dosage Form [PDF]
, 2014 The bioavailability study of Tocomax® 20% powder containing mixed tocotrienols was carried out using Sprague-Dawley rats. The study showed that Tocomax® 20% powder had comparative oral bioavailability as the Tocovid® Suprabio (1.0, 1.0 and 1.2 times for ...
Cheah, Mei Mei
core
Review Article on Inprocess Problems and Evaluation Tests of Tablets Manufacturing [PDF]
, 2023 Tablets are the traditional over all medicinal dosage forms for solid dosages. A tablet is a solid pharmaceutical dosage form that is typically manufactured by compressing or moldings the medicinal component with appropriate diluents.
Hashmi, Masrror +3 more
core +2 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Pharmaceuticals, 2022 This is a registry-based study with the aim of describing and comparing the frequency of manipulations of solid oral and rectal medicines in 2009 and 2019 at inpatient units and an emergency department in a paediatric hospital within a Swedish university
Åsa C. Andersson +4 more
doaj +1 more source
Diphthamide synthesis is linked to the eEF2‐client chaperone machinery
FEBS Letters, EarlyView.The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr +4 more
wiley +1 more source
Biosensors, 2022 Selective spectrofluorometric sensing is introduced for the analysis of non-steroidal anti-androgens, darolutamide, and thalidomide in pharmaceutical preparations and biofluids.
Wael Talaat +2 more
doaj +1 more source
Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells
FEBS Letters, EarlyView.Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga +6 more
wiley +1 more source
Drug Transport System Based on Phospholipid Nanoparticles: Production Technology and Characteristics
Pharmaceutics, 2022 One of the current trends in modern pharmaceuticals is the supply of drugs by transport systems. The use of delivery systems allows to increase the therapeutic efficacy, tolerability, and safety of drug therapy.
Elena G. Tikhonova +7 more
doaj +1 more source