Results 81 to 90 of about 653,512 (354)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Intranasal scopolamine preparation and method [PDF]

A new method and preparation for intranasal delivery of scopolamine provides a safe and effective treatment for motion sickness and other conditions requiring anticholinergic therapy. The preparation can be in the form of aqueous nasal drops, mist spray,
Cintron, Nitza M., Putcha, Lakshmi
core   +1 more source

Tocotrienols In Solid Dosage Form [PDF]

, 2014
The bioavailability study of Tocomax® 20% powder containing mixed tocotrienols was carried out using Sprague-Dawley rats. The study showed that Tocomax® 20% powder had comparative oral bioavailability as the Tocovid® Suprabio (1.0, 1.0 and 1.2 times for ...
Cheah, Mei Mei
core  

Comparison of ibuprofen release from minitablets and capsules containing ibuprofen: β-Cyclodextrin complex [PDF]

, 2010
NOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Pharmaceutics and Biopharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting ...
Amidon, Berggren, Brewster, Bugay, Carr, Cirri, Custodio, Dhareshwar, Engers, Fages, Fell, Frömming, Gil, H.M. Cabral-Marques, Higashi, J.F. Pinto, Khamar, Martin Del Valle, Miller, Mura, Ng, P.C. Costa, P.J. Salústio, Reddy, Rupp, Salústio, Sapkal, Sebhatu, Talari, Wu, Yamamura, Yano   +31 more
core   +1 more source

Ayurvedic Dosage Forms: Pressing Priorities and Challenges therein with Respect to Solid and Semisolid Oral Dosage Forms

Indian Journal of Ayurveda and Integrative Medicine KLEU
Continuous improvements in elevating traditional dosage forms to increase therapeutic efficacy, to enable patient-centric approaches, and to improve patient compliance are becoming more rational with advancements in technology and an advanced vision to ...
Sakshi Badyal, Poonam Dang, Puneet Dhawan, Himanshu Shekhar Tiwari   +3 more
doaj   +1 more source

Acetylsalicylic acid resistance: relevance of correct dosage form

Медицинский совет, 2013
Acetylsalicylic acid (ASA) is a well-known anti-thrombotic agent which has been used in medical practice for more than 100 years. The effectiveness of low-dose ASA (75-150 mg/day) in secondary prevention of cardiovascular disease is proved by numerous ...
N. M. Vorobyova
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Study of vinpocetine intranasal dosage form consistence properties

Zaporožskij Medicinskij Žurnal, 2014
Aim. Study of structural-mechanical nasal semisolid dosage forms on emulsion bases providing with optimal release active substance was done. Methods and results.
N. A. Nagornaya, V. V. Gladyshev, B. S. Burlaka   +2 more
doaj   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Influence of key polymer attributes, manufacturing conditions and sintering on abuse deterrence of physical barrier type abuse deterrent formulations (ADF) [PDF]

, 2016
When sintering us used to treat tablet formulations containing polyethylene oxide (PEO), the polymer particles are able to form stronger bonds thereby increase tablet tensile strength. This increase in strength can make it more difficult for an abuser to
Boyce, Heather, Byrn, Steve, Dave, Vivek S, Gurvich, Vadim J., Hoag, Stephen W., Qu, Wen, Saluja, Bhawana, Scoggins, Myke, Smith, Dan   +8 more
core   +1 more source