Results 241 to 250 of about 188,637 (301)
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Rational aspirin dosage regimens
Clinical Pharmacology & Therapeutics, 1978There has been considerable recent concern about the design of safe and effective dosage regimens of aspirin for the treatment of pain, fever, and inflammatory disease. In 1972 the Commissioner of the Food and Drug Administration appointed a special Advisory Panel on Internal Analgesic and Antirheumatic Products to prepare a report on the safety ...
G, Levy, K M, Giacomini
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Optimum Dosage Regimen of Palivizumab?
Therapeutic Drug Monitoring, 2002Palivizumab is a humanized, monoclonal antibody used to protect at-risk infants against respiratory syncytial virus (RSV) infection. The regular dosage scheme causes a low initial trough level and accumulation of the antibody after subsequent injections.
Zaaijer, Hans L. +2 more
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Individualization of phenytoin dosage regimens
Clinical Pharmacology & Therapeutics, 1977Two methods for arriving at optimum, individual phenytoin dosage regimens have been evaluated in 12 patients. (1) Individual Michaelis‐Menten pharmacokinetic parameters for phenytoin were estimated from two reliable steady‐state phenytoin serum concentrations resulting from different daily doses: The observed steady‐state phenytoin serum levels ...
T M, Ludden +8 more
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Systematically Individualizing Tobramycin Dosage Regimens
The Journal of Clinical Pharmacology, 1980Tobramycin dosage regimens were individually calculated from serum concentration-time data in 64 patients. Tobramycin pharmacokinetic parameters and dosage requirements demonstrated wide interpatient variation. The tobramycin half-life varied from 0.5 to 8.6 hours in patients with normal serum creatinines.
R J, Cipolle +3 more
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Dosage Regimen Design: Pharmacodynamic Considerations
The Journal of Clinical Pharmacology, 1992Pharmacokinetic methodology to define the time course of drug in an accessible biologic fluid is now well established as are models that relate concentration to effect. When steady-state conditions are not readily available to define a dose- or concentration-effect relationship, non-steady-state pharmacokinetic/pharmacodynamic models can be applied ...
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Cost of individualizing aminoglycoside dosage regimens
American Journal of Health-System Pharmacy, 1979The estimated annual costs associated with operating a clinical pharmacokinetics service within a 450-bed, metropolitan county hospital were studied. Using three aminoglycoside serum level determinations, a computer program estimates the patient's pharmacokinetic variables and calculates a dosage regimen which will maintain serum concentrations in the ...
J L, Bootman +3 more
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Individualization of Drug Dosage Regimens
Clinics in Laboratory Medicine, 1987Individualizing drug dosage regimens is a common application of therapeutic drug monitoring. For drugs with a narrow therapeutic index or variable pharmacokinetic parameters, pharmacokinetic-based dosing can be useful. Pharmacokinetic methods that can aid the clinician in targeting for desired drug serum concentrations have been developed and ...
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Standard gentamicin dosage regimen in neonates
American Journal of Health-System Pharmacy, 1999A standard gentamicin dosage regimen intended to result in fewer trough concentrations of >2 microg/mL was studied. At a neonatal intensive care unit, gentamicin dosage guidelines of 2.5 mg/kg (as the sulfate) administered i.v. over 30 minutes every 12, 18, or 24 hours to neonates with a gestational age (GA) of > or =30 weeks were resulting in some ...
T M, Langlass, T R, Mickle
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Dosage regimens in anaesthesia
Current Opinion in Anaesthesiology, 1992This review concerns recent contributions to establish how much drug to administer and how often. It considers a spectrum of approaches, ranging from the use of simple clinical signs to the development of sophisticated closed-loop control systems.
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Studies on an Intermittent Corticosteroid Dosage Regimen
New England Journal of Medicine, 1963CORTISOL and its derivatives are effective and necessary in the management of some patients with certain diseases, but their prolonged use may be associated with undesirable side effects ranging from minor and annoying ones to life-threatening reactions.
J G, HARTER, W J, REDDY, G W, THORN
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