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Intranasal cocaine self-administration in male mice [PDF]
Nature CommunicationsIntravenous drug self-administration has been widely used in behavioral neuroscience to model addiction and heightened motivational states; however, the technique is notoriously difficult and its utility has been in steady decline.
Kirsty R. Erickson +9 more
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Scientific Reports, 2022 Progressive ratio (PR) schedules of drug delivery are used to determine the ‘motivational’ state of an animal and drug ‘reinforcing efficacy’. This widely held interpretation is supported mainly by the observation that the PR breakpoint (BP) is ...
Vladimir L. Tsibulsky, Andrew B. Norman
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Preclinical Determinants of Drug Choice under Concurrent Schedules of Drug Self-Administration [PDF]
Advances in Pharmacological Sciences, 2012 Drug self-administration procedures have played a critical role in the experimental analysis of psychoactive compounds, such as cocaine, for over 50 years. While there are numerous permutations of this procedure, this paper will specifically focus on choice procedures using concurrent schedules of intravenous drug self-administration.
Banks, Matthew L., Negus, S. Stevens
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Administration of four different doses of gabapentin reduces awakening from breakthrough pain and adverse effects in outpatients with neuropathic pain during the initial titration [PDF]
Korean Journal of Anesthesiology, 2013 BackgroundGabapentin is a safe and well-tolerated anticonvulsant with a wide therapeutic index, and it is used for neuropathic pain. The aim of this study was to compare previous dosing methods with the administration of four different doses of ...
Jong-Yeun Yang +5 more
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The development of a preference for cocaine over food identifies individual rats with addiction-like behaviors. [PDF]
PLoS ONE, 2013 Cocaine dependence is characterized by compulsive drug taking that supercedes other recreational, occupational or social pursuits. We hypothesized that rats vulnerable to addiction could be identified within the larger population based on their ...
Adam N Perry +2 more
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Scientific Reports, 2023 It has been proposed that opiates modulate memory consolidation, but recent work has indicated that this effect may be mediated by how the drug is experienced (i.e., passive injections vs. self-administration).
Travis Francis, Francesco Leri
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PLoS ONE, 2021 BackgroundShortages of opioid analgesics are increasingly common, interfere with patient care and increase healthcare cost. This study characterized the incidence of shortages of opioid analgesics in the period 2015-2019 and evaluated potential ...
Rosa Rodriguez-Monguio +2 more
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Annals of Intensive Care, 2023 Background The prolonged β-lactam antibiotics infusion has been an attractive strategy in severe infections, because it provides a more stable free drug concentration and a longer duration of free drug concentration above the minimum inhibitory ...
Xiaoming Li +6 more
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Naloxone interventions in opioid overdoses: a systematic review protocol
Systematic Reviews, 2019 Background North America is in the midst of an unabated opioid overdose epidemic due to the increasing non-medical use of fentanyl and ultra-potent opioids.
Lindsay Victoria Shaw +9 more
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BMC Health Services Research, 2022 Background Proper home medication management plays a role in improving medication adherence, preserving drug efficacy and ensuring safe medication practices, which is crucial to establish positive treatment outcomes.
Christine Li Ling Lau +6 more
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