Results 41 to 50 of about 490,902 (326)

Prevalence, reasons and factors associated with intentional nonadherence to prescribed medications: a population-based study [PDF]

Revista Brasileira de Epidemiologia
Objective: To evaluate the frequency, reasons and factors associated with intentional nonadherence to drug therapy. Methods: A population-based cross-sectional study was conducted with data from the National Survey on Access, Use and Promotion of ...
Tatiana da Silva Sempé, Emilia da Silva Pons, Tatiane da Silva Dal Pizzol, Daniela Riva Knauth, Sotero Serrate Mengue   +4 more
doaj   +1 more source

Environmental enrichment facilitates cocaine-cue extinction, deters reacquisition of cocaine self-administration and alters AMPAR GluA1 expression and phosphorylation [PDF]

, 2015
This study investigated the combination of environmental enrichment (EE) with cocaine‐cue extinction training on reacquisition of cocaine self‐administration.
Dhonnchadha, Brid Aine Nic, Gauthier, Jamie M., Kantak, Kathleen M., Lin, Amy, Man, Heng-Ye, Spealman, Roger D.   +5 more
core   +1 more source

Mathematical and computational models of drug transport in tumours [PDF]

, 2014
The ability to predict how far a drug will penetrate into the tumour microenvironment within its pharmacokinetic (PK) lifespan would provide valuable information about therapeutic response.
Groh, C.M., Hubbard, Matthew E., Jones, P.F., Loadman, P.M., Periasamy, N., Phillips, R.M., Sleeman, B.D., Smye, S.W., Twelves, C.J.   +8 more
core   +1 more source

Deep brain stimulation of the nucleus accumbens core but not shell reduces motivational components of heroin taking and seeking in rats

Brain and Neuroscience Advances, 2017
Background: Deep brain stimulation is explored as a new intervention for treatment-resistant substance use dependence. A candidate brain region is the nucleus accumbens, due to its involvement in reward and motivation. This study aimed to explore effects
Maria C. Schippers, Mathijs Gaastra, Tanja Mesman, Dustin Schetters, Yvar van Mourik, Damiaan Denys, Tommy Pattij, Taco J. De Vries   +7 more
doaj   +1 more source

Phase I dose-escalation and pharmacokinetic study of dasatinib in patients with advanced solid tumors [PDF]

, 2009
PURPOSE: To determine the maximum tolerated dose, dose-limiting toxicity (DLT), and recommended phase II dose of dasatinib in metastatic solid tumors refractory to standard therapies or for which no effective standard therapy exists.
Agarwal, Shruti, Brunton, Valerie G., Demetri, George D., Evans, T.R. Jeffry, Lo Russo, Patricia, MacPherson, Iain R.J., Morgan, Jeffrey A., Paliwal, Prashni, Voi, Maurizio, Wang, Ding   +9 more
core   +1 more source

Sex and Feeding Status Differently Affect Natural Reward Seeking Behavior in Olfactory Bulbectomized Rats

Frontiers in Behavioral Neuroscience, 2018
Substance abuse and depression are common psychiatric disorders with a high rate of comorbidity. Both conditions affect differently men and women and preclinical research has showed many sex differences in drug addiction and depression.
Jana Ruda-Kucerova, Mary Tresa Zanda, Petra Amchova, Walter Fratta, Walter Fratta, Liana Fattore, Liana Fattore   +6 more
doaj   +1 more source

Audit of outpatient prescription at a tertiary care hospital in South India: An observational study

National Journal of Physiology, Pharmacy and Pharmacology, 2021
Background: Prescriptions are medico-legal documents and it is the duty of every physician to write a complete, legible, and valid prescription to ensure rational drug use and prevent the occurrence of medication errors.
Anuranjani Dhamodharan, Nishanthi Anandabaskar, Nitya Selvaraj, Meenakshi R, Shanthi M   +4 more
doaj   +1 more source

Dramatic increase in lever-pressing activity in rats after training on the progressive ratio schedule of cocaine self-administration

Scientific Reports, 2021
Transition from the highest rate of lever-pressing activity during the unloading (extinction) phase of a cocaine self-administration session to an extremely low activity rate during the remission phase is in many cases gradual. This makes it difficult to
Vladimir L. Tsibulsky, Andrew B. Norman
doaj   +1 more source

Blockade of alpha 2-adrenergic receptors in prelimbic cortex: impact on cocaine self-administration in adult spontaneously hypertensive rats following adolescent atomoxetine treatment [PDF]

, 2017
RATIONALE: Research with the spontaneously hypertensive rat (SHR) model of attention deficit/hyperactivity disorder demonstrated that chronic methylphenidate treatment during adolescence increased cocaine self-administration established during adulthood ...
Baskin, Britahny M., Dhonnchadha, Brid A. Nic, Dwoskin, Linda P., Kantak, Kathleen M.   +3 more
core   +1 more source

Delicate Balances in Cancer Chemotherapy: Modeling Immune Recruitment and Emergence of Systemic Drug Resistance

Frontiers in Immunology, 2020
Metronomic chemotherapy can drastically enhance immunogenic tumor cell death. However, the mechanisms responsible are still incompletely understood. Here, we develop a mathematical model to elucidate the underlying complex interactions between tumor ...
Anh Phong Tran, M. Ali Al-Radhawi, Irina Kareva, Junjie Wu, David J. Waxman, Eduardo D. Sontag, Eduardo D. Sontag, Eduardo D. Sontag   +7 more
doaj   +1 more source