Results 11 to 20 of about 490,902 (326)

Preclinical Determinants of Drug Choice under Concurrent Schedules of Drug Self-Administration [PDF]

Advances in Pharmacological Sciences, 2012
Drug self-administration procedures have played a critical role in the experimental analysis of psychoactive compounds, such as cocaine, for over 50 years. While there are numerous permutations of this procedure, this paper will specifically focus on choice procedures using concurrent schedules of intravenous drug self-administration.
Banks, Matthew L., Negus, S. Stevens
  +8 more sources

Online scheduling using a fixed template: the case of outpatient chemotherapy drug administration [PDF]

Health Care Management Science, 2022
AbstractIn this paper, we use a fixed template of slots for the online scheduling of appointments. The template is a link between planning the service capacity at a tactical level and online scheduling at an operational level. We develop a detailed heuristic for the case of drug administration appointments in outpatient chemotherapy.
Alireza F. Hesaraki, Nico P. Dellaert, Ton de Kok   +2 more
openaire   +6 more sources

Random-ratio schedules produce greater demand for i.v. drug administration than fixed-ratio schedules in rhesus monkeys [PDF]

Psychopharmacology, 2014
Organisms emit more responses when food is provided according to random as compared with fixed schedules of reinforcement. Similarly, many human behaviors deemed compulsive are maintained on variable schedules (e.g., gambling). If greater amounts of behavior are maintained by drugs of abuse when earned according to variably reinforced schedules, this ...
Carla H, Lagorio, Gail, Winger
openaire   +4 more sources

Low-dose (5 mg/kg) desferrioxamine treatment in acutely aluminium-intoxicated haemodialysis patients using two drug administration schedules [PDF]

Nephrology Dialysis Transplantation, 1996
According to the recommendations proposed at The Consensus Conference on Diagnosis and Treatment of Aluminium Overload in End-Stage Renal Failure Patients, Paris, 1992 low-dose desferrioxamine (DFO) treatment was applied for the first time in 41 acutely aluminium-intoxicated patients.DFO-related neurological/ophthalmological side-effects were observed ...
Barata, J.D., d' Haese, Patrick C., Pires, C., Lamberts, L.V., Simoes, J., de Broe, Marc E.   +5 more
  +6 more sources

Defining the Optimal Schedule of Drug Administration: Art or Science? [PDF]

Journal of Clinical Oncology, 2008
The optimal use of the oral fluoropyrimidine carbamate capecitabine (Xeloda; Hoffman-Roche, Nutley, NJ) has been the subject of much debate, with empirical exploration of both doses and schedules different from those approved. In the current issue of the Journal, Traina et al describe a phase I trial of a 7-day capecitabine schedule derived rationally ...
Chris Twelves
openaire   +2 more sources

Intranasal cocaine self-administration in male mice [PDF]

Nature Communications
Intravenous drug self-administration has been widely used in behavioral neuroscience to model addiction and heightened motivational states; however, the technique is notoriously difficult and its utility has been in steady decline.
Kirsty R. Erickson, Yizhen Quan, Zahra Z. Farahbakhsh, Hannah E. Branthwaite, Keaton Song, Justin D. Kim, Janice J. Lee, Katherine N. Gibson-Corley, Eyal Y. Kimchi, Cody A. Siciliano   +9 more
doaj   +2 more sources

Enhanced self-administration of the CB1 receptor agonist WIN55,212-2 in olfactory bulbectomized rats: evaluation of possible serotonergic and dopaminergic underlying mechanisms [PDF]

Frontiers in Pharmacology, 2014
Depression has been associated with drug consumption, including heavy or problematic cannabis use. According to an animal model of depression and substance use disorder comorbidity, we combined the olfactory bulbectomy model of depression with ...
Petra eAmchova, Petra eAmchova, Jana eKucerova, Jana eKucerova, Valentina eGiugliano, Zuzana eBabinska, Zuzana eBabinska, Mary Tresa Zanda, Maria eScherma, Ladislav eDusek, Paola eFadda, Paola eFadda, Paola eFadda, Vincenzo eMicale, Alexandra eSulcova, Walter eFratta, Walter eFratta, Walter eFratta, Liana eFattore, Liana eFattore   +19 more
doaj   +3 more sources

Nicotine and cocaine self-administration using a multiple schedule of intravenous drug and sucrose reinforcement in rats [PDF]

Behavioural Pharmacology, 2010
There appears to be a relatively narrow range of contingencies in which intravenous (i.v) infusions of nicotine will maintain responding in rats. The schedule of reinforcement typically used when investigating i.v. nicotine self-administration is a simple fixed-ratio (FR) schedule.
Dustin J, Stairs, Nichole M, Neugebauer, Michael T, Bardo   +2 more
openaire   +3 more sources

Investigation on Administration Schedule Practice of Hypnotic Drugs of Outpatients.

Japanese Journal of Hospital Pharmacy, 1992
KENZO YONEZAWA, ISAMU YAMAGUCHI, FUMIAKI ISHIZAWA, YASUNORI SUGAWARA, EMIKO TANAKA, TAMAO MIURA, HIROMI ONUKI   +6 more
openaire   +3 more sources

Consideration on proper administration schedule of Antibody Drug Conjugate （ADC） drugs in clinic

Drug Delivery System
Toshimitsu Uenaka
openaire   +3 more sources