Results 11 to 20 of about 150,877 (218)

Targeted drug delivery by gemtuzumab ozogamicin: mechanism-based mathematical model for treatment strategy improvement and therapy individualization. [PDF]

PLoS ONE, 2011
Gemtuzumab ozogamicin (GO) is a chemotherapy-conjugated anti-CD33 monoclonal antibody effective in some patients with acute myeloid leukemia (AML). The optimal treatment schedule and optimal timing of GO administration relative to other agents remains ...
Eva Jager, Vincent H J van der Velden, Jeroen G te Marvelde, Roland B Walter, Zvia Agur, Vladimir Vainstein   +5 more
doaj   +1 more source

Cost-minimization analysis of individually tailored or fixed-scheduled rituximab maintenance therapy for antineutrophil-cytoplasm antibody associated vasculitides [PDF]

Farmacia Hospitalaria, 2020
Objective: Patients included in MAINRITSAN2 trial received either an individually tailored or a fixed-schedule therapy with rituximab as maintenance treatment of antineutrophil cytoplasm antibody associated vasculitides.
Ana Belén Guisado-Gil, Marina Muñoz-Burgos, Ana Ortega-Eslava, Francisco Javier García-Hernández, Bernardo Santos-Ramos   +4 more
doaj   +1 more source

Sequential dose-dense single agent chemotherapy for locally advanced breast cancer [PDF]

Archive of Oncology, 2003
Chemotherapy of breast cancer is still the area of intensive research. Based on mathematical model of tumor cell growth kinetics, articulated by Larry Norton, novel concept of chemotherapy in breast cancer was launched and it implies dose-densification ...
Vrbić Svetislav, Pejčić Ivica, Filipović Slađana, Radić Stojan S.   +3 more
doaj   +1 more source

Abordaje terapéutico de la otitis media aguda en atención primaria de un área urbana. Evaluación de la prescripción diferida de antibióticos

Anales de Pediatría, 2022
Resumen: Introducción: La otitis media aguda (OMA) es una de las causas más frecuentes de consulta y prescripción antibiótica en pediatría. El objetivo de este trabajo es valorar la prescripción antibiótica diferida en OMA en pediatría en atención ...
María García Ventura, César García Vera, Juan Ruiz-Canela Cáceres   +2 more
doaj   +1 more source

Prevalence, reasons and factors associated with intentional nonadherence to prescribed medications: a population-based study [PDF]

Revista Brasileira de Epidemiologia
Objective: To evaluate the frequency, reasons and factors associated with intentional nonadherence to drug therapy. Methods: A population-based cross-sectional study was conducted with data from the National Survey on Access, Use and Promotion of ...
Tatiana da Silva Sempé, Emilia da Silva Pons, Tatiane da Silva Dal Pizzol, Daniela Riva Knauth, Sotero Serrate Mengue   +4 more
doaj   +1 more source

Deep brain stimulation of the nucleus accumbens core but not shell reduces motivational components of heroin taking and seeking in rats

Brain and Neuroscience Advances, 2017
Background: Deep brain stimulation is explored as a new intervention for treatment-resistant substance use dependence. A candidate brain region is the nucleus accumbens, due to its involvement in reward and motivation. This study aimed to explore effects
Maria C. Schippers, Mathijs Gaastra, Tanja Mesman, Dustin Schetters, Yvar van Mourik, Damiaan Denys, Tommy Pattij, Taco J. De Vries   +7 more
doaj   +1 more source

Sex and Feeding Status Differently Affect Natural Reward Seeking Behavior in Olfactory Bulbectomized Rats

Frontiers in Behavioral Neuroscience, 2018
Substance abuse and depression are common psychiatric disorders with a high rate of comorbidity. Both conditions affect differently men and women and preclinical research has showed many sex differences in drug addiction and depression.
Jana Ruda-Kucerova, Mary Tresa Zanda, Petra Amchova, Walter Fratta, Walter Fratta, Liana Fattore, Liana Fattore   +6 more
doaj   +1 more source

Audit of outpatient prescription at a tertiary care hospital in South India: An observational study

National Journal of Physiology, Pharmacy and Pharmacology, 2021
Background: Prescriptions are medico-legal documents and it is the duty of every physician to write a complete, legible, and valid prescription to ensure rational drug use and prevent the occurrence of medication errors.
Anuranjani Dhamodharan, Nishanthi Anandabaskar, Nitya Selvaraj, Meenakshi R, Shanthi M   +4 more
doaj   +1 more source

Delicate Balances in Cancer Chemotherapy: Modeling Immune Recruitment and Emergence of Systemic Drug Resistance

Frontiers in Immunology, 2020
Metronomic chemotherapy can drastically enhance immunogenic tumor cell death. However, the mechanisms responsible are still incompletely understood. Here, we develop a mathematical model to elucidate the underlying complex interactions between tumor ...
Anh Phong Tran, M. Ali Al-Radhawi, Irina Kareva, Junjie Wu, David J. Waxman, Eduardo D. Sontag, Eduardo D. Sontag, Eduardo D. Sontag   +7 more
doaj   +1 more source

Dramatic increase in lever-pressing activity in rats after training on the progressive ratio schedule of cocaine self-administration

Scientific Reports, 2021
Transition from the highest rate of lever-pressing activity during the unloading (extinction) phase of a cocaine self-administration session to an extremely low activity rate during the remission phase is in many cases gradual. This makes it difficult to
Vladimir L. Tsibulsky, Andrew B. Norman
doaj   +1 more source