Results 241 to 250 of about 8,241,341 (344)

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Dose-Response Relationship of Phloretin Therapy on Water and Glucose Transport during Experimental Peritoneal Dialysis. [PDF]

Kidney360
Björk M, Martus G, Öberg CM.
europepmc   +1 more source

The dose-response relationship between cigarette consumption, biochemical markers and risk of lung cancer

, 1997
MR Law, Joan K. Morris, HC Watt, NJ Wald
openalex   +1 more source

Dose–response relationships: an overview, a generative model and its application to the verification of descriptive models [PDF]

, 2002
M.A. Murado, Ma.P. González, José Antonio Vázquez   +2 more
openalex   +1 more source

A generalized dose-response relationship for adenovirus infection and illness by exposure pathway

Epidemiology and Infection, 2016
P. Teunis, J. Schijven, S. Rutjes
semanticscholar   +1 more source

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source

Clinical Evidence of the Relationship Between Alanine Aminotransferase and Diabetic Kidney Disease

Diabetes, Metabolic Syndrome and Obesity
Yaru Bi,1,* Yang Yang,2,* Xiaojie Yuan,3 Jiping Wang,3 Zhiyuan Liu,4 Suyan Tian,5 Chenglin Sun1,3 1Department of Endocrinology and Metabolism, First Hospital of Jilin University, Changchun, 130000, People’s Republic of China; 2Department of ...
Bi Y, Yang Y, Yuan X, Wang J, Liu Z, Tian S, Sun C   +6 more
doaj  

Exploring the Dose-Response Relationship Between Nature-Based Outdoor Activities, Nature Connectedness and Social Health In Adolescents: A Quasi-Experimental Controlled Study. [PDF]

J Adolesc
Choe EY, Lee JY, Zhu S.
europepmc   +1 more source

Lack of a Dose‐response Relationship for Carcinogenicity in the Rat Liver with Low Doses of 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline or N‐Nitrosodiethylamine [PDF]

, 2002
Shoji Fukushima, Hideki Wanibuchi, Keiichirou Morimura, Min Wei, Dai Nakae, Yoichi Konishi, Hiroyuki Tsuda, Nobuaki Uehara, Katsumi Imaida, Tomoyuki Shirai, Masae Tatematsu, Tetsuya Tsukamoto, Masao Hirose, Fumio Furukawa, Keiji Wakabayashi, Yukari Totsuka   +15 more
openalex   +1 more source

3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes

Advanced Biology, EarlyView.
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins, Ah Joung Yu, Cheryl T. Gomillion   +2 more
wiley   +1 more source