Results 231 to 240 of about 7,945,859 (267)

Genetic dose-response modelling predicts drug mechanisms, dosing, and adverse events

Stefanucci L, Considine D, Ke Z, Hellewell J, Bakker O, Alcantara MP, Soskic B, Freimann K, Turchin MC, Holzinger ER, Chiou J, Nakic N, Ongen H, Lorenc A, Ghoussaini M, Buniello A, Dunham I, McDonagh EM, Maranville JC, Lees JA, Alasoo K, Ochoa D, Tsepilov Y, Trynka G.   +23 more
europepmc   +1 more source

Effects of table tennis on vision in children and adolescents: a multilevel dose-response meta-analysis. [PDF]

Front Med (Lausanne)
Jin X, Wang Y, Guo J, Cao A.
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Isometric exercise training and blood pressure control: exploring the dose-response to training frequency in a randomised controlled trial. [PDF]

BMJ Open Sport Exerc Med
Swift HT, Pedlar C, Coleman DA, Buckley JP, Wiles JD.   +4 more
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Comprehensive Effects of Magnesium Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose-Response Meta-Analysis. [PDF]

Nutrients
Mohammadi S, Palermo A, Ojani P, Alaghemand N, Pirayvatlou PS, Mirkarimi M, Mavi SA, Tahouri K, Shokouhifar S, Ettehad Y, Borzabadi A, Ashtary-Larky D, Suzuki K, Bouzas C, Rodrigues D, Tur JA.   +15 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Dose-response relationship between physical activity and sarcopenia in peritoneal dialysis patients. [PDF]

Ren Fail
Xiong Y, Huang J, Wu Y, Xu X, Zheng Y, Liu H, Lang C, Zhang X, Sun X, Wu K, Zheng Q, Zhou H, Yuan J, Li H.   +13 more
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Positive and Negative Symptoms Changes in Schizophrenia Patients on Antipsychotic Treatment: a Systematic Review and Dose-Response Meta-analysis. [PDF]

Schizophr Bull
Lin X, Siafis S, Tian J, Wu H, Correll CU, Schneider-Thoma J, Leucht S.   +6 more
europepmc   +1 more source