Results 181 to 190 of about 448,304 (219)

Central and peripheral changes in oxygenation and temperatures induced by intravenous nicotine in freely moving male rats. [PDF]

Brain Res
Arce A, Limiac F, Kiyatkin EA.
europepmc   +1 more source

Positive Affect Is Associated With Better Physical Function in Early Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective This study examined the association between positive affect and physical function in individuals with early rheumatoid arthritis (RA). Methods We analyzed baseline data from 129 adults with early RA (persistent joint symptoms for ≤24 months) and active disease enrolled in the Central Pain in RA 2 (CPIRA‐2) study.
Burcu Aydemir, Jing Song, Lutfiyya N. Muhammad, Wendy Marder, Kevin Deane, Clifton Bingham, Lisa A. Mandl, Robert Edwards, Judith T. Moskowitz, Yvonne C. Lee   +9 more
wiley   +1 more source

Effect Modification of Cigarette Smoking on the Relationship Between Posttraumatic Stress Disorder, Other Mental Health Conditions, and Rheumatoid Arthritis Risk: A Large Case‐Control Study in US Veterans

Arthritis Care &Research, EarlyView.
Objective We examined associations of posttraumatic stress disorder (PTSD) and other mental health disorders (OMH) with rheumatoid arthritis (RA), accounting for effects of smoking. Methods We conducted a matched case‐control study, identifying incident RA cases and controls using national Veterans Health Administration data (2006–2019).
Kelsey Coziahr, Harlan Sayles, Tate M. Johnson, Joshua F. Baker, Punyasha Roul, Grant W. Cannon, Gary A. Kunkel, Katherine D. Wysham, Gail S. Kerr, Amir A. Razmjou, Isaac Smith, Jennifer L. Barton, Maria I. Danila, Jonathan S. Richards, Bryant R. England, Ted R. Mikuls   +15 more
wiley   +1 more source

Population Pharmacokinetic, Exposure-Response Efficacy and Safety Analyses of Favezelimab in Patients With Solid Tumors. [PDF]

Clin Transl Sci
Gaurav M, Barcomb H, Maxwell KF, Kandala B, Chatterjee MS.   +4 more
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Hierarchical Composite Endpoints for Dose Optimization in Early Phase Oncology Trials. [PDF]

Pharm Stat
Wu Y, Guo X, Li R, Le Corre C.
europepmc   +1 more source

Cardiac Vagal Decoupling in Canine Anesthesia: A Physiological Concept for Graded Vasopressor Titration. [PDF]

Vet Sci
Nagahama S.
europepmc   +1 more source

Equipotent Doses and ED95 Extrapolation: Methodological Concerns in Trials of Ciprofol-Esketamine/Sufentanil for Elderly ESD [Letter]. [PDF]

Drug Des Devel Ther
Li L, Zhang Z, Wang Z, Li C.
europepmc   +1 more source