Results 251 to 260 of about 734,043 (307)

Camizestrant causes reversible pharmacological effects on retinal responses in rats. [PDF]

Transl Oncol
Hamm G, Maglennon G, Purbrick S, Flint L, Hawthorne G, Atkinson J, Macdonald R, Harmer A, Jones S, Krakova Y, Ver Hoeve J, Walding A, Wright L.   +12 more
europepmc   +1 more source

Dose-response relationship between the triglyceride-glucose index and metabolic syndrome risk in patients with type 2 diabetes: a cross-sectional analysis of 1,560 cases. [PDF]

Front Endocrinol (Lausanne)
Chen F, Gu Z, Peng R.
europepmc   +1 more source

Pulmonary toxicity induced by carfilzomib: a case report and review of the literature. [PDF]

J Med Case Rep
Ziarkiewicz M, Zacny A, Basak G, Grabowska-Derlatka L.   +3 more
europepmc   +1 more source

Dose-response relationship and incidence of adverse drug reactions with isradipine in patients with essential hypertension [PDF]

The American Journal of Medicine, 1989
Based on pooled data from three randomized placebo-controlled dose-finding studies in a total of 489 patients, the dose-response relationship for efficacy and adverse events was estimated, using the Michaelis-Menten equation: Effect = maximal effect multiplied by dose/constant plus dose. Three conclusions were derived from the pooled data: (1) A marked
K. Simonsen, Carl-David Sundstedt
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An Alternate Method for Estimating the Dose-Response Relationships of Neuromuscular Blocking Drugs

Anesthesia & Analgesia, 2000
Slopes of the dose-response relationships for all available neuromuscular blocking drugs appear to be essentially parallel and to approximate a log-dose/logit value of 4.75. We tested the possibility of estimating both 50% effective dose (ED(50)) and 95% effective dose (ED(95)) values from a single dose-response data point when that slope is postulated.
George G. Neuman, Aaron F. Kopman, Monika M. Klewicka   +2 more
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The multiple propensity score for analysis of dose–response relationships in drug safety studies

Pharmacoepidemiology and Drug Safety, 2001
AbstractIn order to detect adverse drug reactions, large observational drug safety studies are necessary as randomized clinical trials rarely have enough power. However, in order to obtain reliable results the issue of confounding, especially confounding by indication, should be addressed.
Wang, Jixian, Donnan, Peter T., Steinke, Douglas, MacDonald, Thomas M.   +3 more
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Dose‐response relationship characterization in current anti‐hypertensive drug development

Clinical Pharmacology & Therapeutics, 2003
Clinical Pharmacology & Therapeutics (2003) 73, P68–P68; doi:
R. J. Lipicky, Jogarao V. S. Gobburu
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A Flexible Bayesian Approach for Modeling Monotonic Dose–Response Relationships in Drug Development Trials

Journal of Biopharmaceutical Statistics, 2015
Clinical trials often involve comparing 2-4 doses or regimens of an experimental therapy with a control treatment. These studies might occur early in a drug development process, where the aim might be to demonstrate a basic level of proof (the so-called proof of concept (PoC) studies), at a later stage, to help establish a dose or doses that should be ...
Amy Racine, David Ohlssen
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Dose-response relationships with antihypertensive drugs

Pharmacology & Therapeutics, 1992
A variety of antihypertensive drugs have been introduced into clinical practice at excessively high dose. Examples include most thiazide diuretics, propranolol, oxprenolol, atenolol, methyldopa, hydralazine and captopril. These very high doses have usually resulted from studies in which doses have been increased at regular intervals until the desired ...
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