Results 261 to 270 of about 435,631 (309)
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Journal of Psychoactive Drugs, 1995
This study examined the impact of treatment intensity on cocaine use. Seventy-seven cocaine-using methadone patients were enrolled in a six-month, structured, manual-driven, cognitive-behavioral treatment program. Sessions consisted of five individual and/or group sessions per week.
Andrew Rosenblum +2 more
exaly +3 more sources
This study examined the impact of treatment intensity on cocaine use. Seventy-seven cocaine-using methadone patients were enrolled in a six-month, structured, manual-driven, cognitive-behavioral treatment program. Sessions consisted of five individual and/or group sessions per week.
Andrew Rosenblum +2 more
exaly +3 more sources
The multiple propensity score for analysis of dose–response relationships in drug safety studies [PDF]
Pharmacoepidemiology and Drug Safety, 2001 AbstractIn order to detect adverse drug reactions, large observational drug safety studies are necessary as randomized clinical trials rarely have enough power. However, in order to obtain reliable results the issue of confounding, especially confounding by indication, should be addressed.
Wang, Jixian +3 more
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An Alternate Method for Estimating the Dose-Response Relationships of Neuromuscular Blocking Drugs
Anesthesia & Analgesia, 2000Slopes of the dose-response relationships for all available neuromuscular blocking drugs appear to be essentially parallel and to approximate a log-dose/logit value of 4.75. We tested the possibility of estimating both 50% effective dose (ED(50)) and 95% effective dose (ED(95)) values from a single dose-response data point when that slope is postulated.
A F, Kopman, M M, Klewicka, G G, Neuman
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Pharmacogenetics and Genetic Factors in Drug Dose-Response Relationships
2023Abstract Pharmacogenetics and pharmacogenomics are related areas of research that aim to determine the relationship between genotypic variation, including changes in gene expression, and variations in drug response seen across patient groups. Understanding the genetic bases of variability in drug response due to altered pharmacokinetics (
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Dose-response relationships with antihypertensive drugs
Pharmacology & Therapeutics, 1992A variety of antihypertensive drugs have been introduced into clinical practice at excessively high dose. Examples include most thiazide diuretics, propranolol, oxprenolol, atenolol, methyldopa, hydralazine and captopril. These very high doses have usually resulted from studies in which doses have been increased at regular intervals until the desired ...
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Cellular and Molecular Bioengineering, 2021
Ischemic stroke treatment has advanced in the last two decades and intravenous thrombolysis is now considered the standard of care for selected patients. Recanalization can also be achieved by mechanical endovascular treatment for patients with large vessel occlusions.
Qin, Zhen +4 more
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Ischemic stroke treatment has advanced in the last two decades and intravenous thrombolysis is now considered the standard of care for selected patients. Recanalization can also be achieved by mechanical endovascular treatment for patients with large vessel occlusions.
Qin, Zhen +4 more
openaire +3 more sources
Dose‐response relationship characterization in current anti‐hypertensive drug development
Clinical Pharmacology & Therapeutics, 2003Clinical Pharmacology & Therapeutics (2003) 73, P68–P68; doi:
J. V. Gobburu, R. J. Lipicky
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AAPS PharmSciTech, 2023
The objective of this study is to investigate the dose-response relationship between various concentrations of permeation enhancers (PEs) and their ability to enhance drug release from a polymer matrix, utilizing an innovative parameter known as release enhancement efficiency (K). Additionally, the molecular mechanism underlying dynamic enhancement was
Jiuheng Ruan +3 more
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The objective of this study is to investigate the dose-response relationship between various concentrations of permeation enhancers (PEs) and their ability to enhance drug release from a polymer matrix, utilizing an innovative parameter known as release enhancement efficiency (K). Additionally, the molecular mechanism underlying dynamic enhancement was
Jiuheng Ruan +3 more
openaire +2 more sources
The American Journal of Medicine, 1989
Based on pooled data from three randomized placebo-controlled dose-finding studies in a total of 489 patients, the dose-response relationship for efficacy and adverse events was estimated, using the Michaelis-Menten equation: Effect = maximal effect multiplied by dose/constant plus dose. Three conclusions were derived from the pooled data: (1) A marked
K, Simonsen, C D, Sundstedt
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Based on pooled data from three randomized placebo-controlled dose-finding studies in a total of 489 patients, the dose-response relationship for efficacy and adverse events was estimated, using the Michaelis-Menten equation: Effect = maximal effect multiplied by dose/constant plus dose. Three conclusions were derived from the pooled data: (1) A marked
K, Simonsen, C D, Sundstedt
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Drug Action: Target Tissue, Dose-Response Relationships, and Receptors
1972In the complex processes of drug action three main phases can be distinguished (Fig. 1): the pharmaceutical phase, the pharmacokinetic phase and the pharmacodynamic phase. They form a suitable frame for the discussion of the chemical basis of drug action.
E. J. Ariëns, A. M. Simonis
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