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Dose‐response relationship characterization in current anti‐hypertensive drug development

Clinical Pharmacology & Therapeutics, 2003
Clinical Pharmacology & Therapeutics (2003) 73, P68–P68; doi:
J. V. Gobburu, R. J. Lipicky
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An Alternate Method for Estimating the Dose-Response Relationships of Neuromuscular Blocking Drugs

Anesthesia & Analgesia, 2000
Slopes of the dose-response relationships for all available neuromuscular blocking drugs appear to be essentially parallel and to approximate a log-dose/logit value of 4.75. We tested the possibility of estimating both 50% effective dose (ED(50)) and 95% effective dose (ED(95)) values from a single dose-response data point when that slope is postulated.
A F, Kopman, M M, Klewicka, G G, Neuman
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Dose-response relationships with antihypertensive drugs

Pharmacology & Therapeutics, 1992
A variety of antihypertensive drugs have been introduced into clinical practice at excessively high dose. Examples include most thiazide diuretics, propranolol, oxprenolol, atenolol, methyldopa, hydralazine and captopril. These very high doses have usually resulted from studies in which doses have been increased at regular intervals until the desired ...
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Pharmacogenetics and Genetic Factors in Drug Dose-Response Relationships

2023
Abstract Pharmacogenetics and pharmacogenomics are related areas of research that aim to determine the relationship between genotypic variation, including changes in gene expression, and variations in drug response seen across patient groups. Understanding the genetic bases of variability in drug response due to altered pharmacokinetics (
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