Results 291 to 300 of about 925,610 (310)

Strain differences in the dose–response relationship for morphine self-administration and impulsive choice between Lewis and Fischer 344 rats

Journal of Psychopharmacology, 2011
Dose–response studies are thought to be a valuable tool to predict the most genetically drug-vulnerable individuals. However, dose–response curves for morphine self-administration have not yet been examined and nor strain differences might be evident ...
C. Garcı́a-Lecumberri, I. Torres, Sonsoles Martı́n, J. A. Crespo, M. Miguéns, Cristina Nicanor, A. Higuera-Matas, E. Ambrosio   +7 more
semanticscholar   +1 more source

Age-dependent dose-response relationship of ORG NC 45 in anaesthetized patients.

British Journal of Anaesthesia, 1983
The effects of age on the dose of Org NC 45 were studied in 24 healthy, anaesthetized patients using an on-demand infusion of the drug which produced a stable twitch height of 10% of its initial value.
A. d'Hollander, F. Massaux, M. Nevelsteen, S. Ágoston   +3 more
semanticscholar   +1 more source

Dose-response relationship of epirubicin in the treatment of postmenopausal patients with metastatic breast cancer: a randomized study of epirubicin at four different dose levels performed by the Danish Breast Cancer Cooperative Group.

Journal of Clinical Oncology, 1996
PURPOSE To test for possible correlations between dose of single-drug epirubicin and efficacy/toxicity in postmenopausal women with metastatic breast cancer.
Lars Bastholt, Mads Dalmark, S. Gjedde, Per Pfeiffer, Dorte Pedersen, Erik Sandberg, M. Kjaer, H. T. Mouridsen, Carsten Rose, O. S. Nielsen, Preben Jakobsen, Søren M. Bentzen   +11 more
semanticscholar   +1 more source

Dose-response relationship in isotretinoin therapy for conglobate acne.

Dermatologica, 1983
58 male patients with therapy-resistant conglobate acne were randomly selected for treatment with isotretinoin 1.0 or 0.5 mg/kg bodyweight. 27 patients received the high-dose regimen and 31 patients the lower dosage.
H.L.M. van der Meeren, J. G. V. D. Schroeff, T. Stijnen, J. A. V. Duren, Hulens Dries, P. C. V. V. Vader   +5 more
semanticscholar   +1 more source

BMA‐Mod: A Bayesian model averaging strategy for determining dose‐response relationships in the presence of model uncertainty

Biometrical journal. Biometrische Zeitschrift, 2018
Successful pharmaceutical drug development requires finding correct doses. The issues that conventional dose‐response analyses consider, namely whether responses are related to doses, which doses have responses differing from a control dose response, the
A. Gould
semanticscholar   +1 more source

Naproxen dose and concentration: response relationship in rheumatoid arthritis.

British Journal of Rheumatology, 1988
Information on the relationship between the plasma concentration of nonsteroidal anti-inflammatory drugs (NSAIDs) and clinical response in rheumatoid arthritis is sparse. As a result treatment is often relatively empirical.
F. Dunagan, P. McGill, A. Kelman, B. Whiting   +3 more
semanticscholar   +1 more source

Developing a Multi-Dose Computational Model for Drug-Induced Hepatotoxicity Prediction Based on Toxicogenomics Data

IEEE/ACM Transactions on Computational Biology & Bioinformatics, 2019
Drug-induced hepatotoxicity may cause acute and chronic liver disease, leading to great concern for patient safety. It is also one of the main reasons for drug withdrawal from the market.
R. Su, Huichen Wu, Bo Xu, Xiaofeng Liu, Leyi Wei   +4 more
semanticscholar   +1 more source

Dose‐response relationship between sulfonylureas and major adverse cardiovascular events in elderly patients with type 2 diabetes

Pharmacoepidemiology and Drug Safety, 2016
A. Abdelmoneim, D. Eurich, A. Senthilselvan, Weiyu Qiu, S. Simpson   +4 more
semanticscholar   +1 more source

European study on dose-response relationship of acarbose as a first-line drug in non-insulin-dependent diabetes mellitus: efficacy and safety of low and high doses

Acta Diabetologica, 1998
S. Fischer, Markolf Hanefeld, M. Spengler, K. Boehme, T. Temelkova-Kurktschiev   +4 more
semanticscholar   +1 more source

The Hematopoietic Syndrome of the Acute Radiation Syndrome in Rhesus Macaques: A Systematic Review of the Lethal Dose Response Relationship

Health Physics, 2015
T. MacVittie, A. Farese, William E. Jackson   +2 more
semanticscholar   +1 more source