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Pharmacogenetics and Genetic Factors in Drug Dose-Response Relationships
2023Abstract Pharmacogenetics and pharmacogenomics are related areas of research that aim to determine the relationship between genotypic variation, including changes in gene expression, and variations in drug response seen across patient groups. Understanding the genetic bases of variability in drug response due to altered pharmacokinetics (
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Dose‐response relationship characterization in current anti‐hypertensive drug development
Clinical Pharmacology & Therapeutics, 2003Clinical Pharmacology & Therapeutics (2003) 73, P68–P68; doi:
J. V. Gobburu, R. J. Lipicky
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AAPS PharmSciTech, 2023
The objective of this study is to investigate the dose-response relationship between various concentrations of permeation enhancers (PEs) and their ability to enhance drug release from a polymer matrix, utilizing an innovative parameter known as release enhancement efficiency (K). Additionally, the molecular mechanism underlying dynamic enhancement was
Jiuheng Ruan +3 more
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The objective of this study is to investigate the dose-response relationship between various concentrations of permeation enhancers (PEs) and their ability to enhance drug release from a polymer matrix, utilizing an innovative parameter known as release enhancement efficiency (K). Additionally, the molecular mechanism underlying dynamic enhancement was
Jiuheng Ruan +3 more
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Cellular and Molecular Bioengineering, 2021
Ischemic stroke treatment has advanced in the last two decades and intravenous thrombolysis is now considered the standard of care for selected patients. Recanalization can also be achieved by mechanical endovascular treatment for patients with large vessel occlusions.
Qin, Zhen +4 more
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Ischemic stroke treatment has advanced in the last two decades and intravenous thrombolysis is now considered the standard of care for selected patients. Recanalization can also be achieved by mechanical endovascular treatment for patients with large vessel occlusions.
Qin, Zhen +4 more
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The American Journal of Medicine, 1989
Based on pooled data from three randomized placebo-controlled dose-finding studies in a total of 489 patients, the dose-response relationship for efficacy and adverse events was estimated, using the Michaelis-Menten equation: Effect = maximal effect multiplied by dose/constant plus dose. Three conclusions were derived from the pooled data: (1) A marked
K, Simonsen, C D, Sundstedt
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Based on pooled data from three randomized placebo-controlled dose-finding studies in a total of 489 patients, the dose-response relationship for efficacy and adverse events was estimated, using the Michaelis-Menten equation: Effect = maximal effect multiplied by dose/constant plus dose. Three conclusions were derived from the pooled data: (1) A marked
K, Simonsen, C D, Sundstedt
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Journal of Biopharmaceutical Statistics, 2015
Clinical trials often involve comparing 2-4 doses or regimens of an experimental therapy with a control treatment. These studies might occur early in a drug development process, where the aim might be to demonstrate a basic level of proof (the so-called proof of concept (PoC) studies), at a later stage, to help establish a dose or doses that should be ...
David, Ohlssen, Amy, Racine
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Clinical trials often involve comparing 2-4 doses or regimens of an experimental therapy with a control treatment. These studies might occur early in a drug development process, where the aim might be to demonstrate a basic level of proof (the so-called proof of concept (PoC) studies), at a later stage, to help establish a dose or doses that should be ...
David, Ohlssen, Amy, Racine
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Journal of Psychopharmacology, 2011
Dose–response studies are thought to be a valuable tool to predict the most genetically drug-vulnerable individuals. However, dose–response curves for morphine self-administration have not yet been examined and nor strain differences might be evident ...
C. Garcı́a-Lecumberri +7 more
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Dose–response studies are thought to be a valuable tool to predict the most genetically drug-vulnerable individuals. However, dose–response curves for morphine self-administration have not yet been examined and nor strain differences might be evident ...
C. Garcı́a-Lecumberri +7 more
semanticscholar +1 more source
Drug Action: Target Tissue, Dose-Response Relationships, and Receptors
1972In the complex processes of drug action three main phases can be distinguished (Fig. 1): the pharmaceutical phase, the pharmacokinetic phase and the pharmacodynamic phase. They form a suitable frame for the discussion of the chemical basis of drug action.
E. J. Ariëns, A. M. Simonis
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2021
The human disease tuberculosis (TB) is the leading cause of death from a single infectious agent. A quarter of the world's population is estimated to be latently infected. Drug development and screening is slow and costly. We have developed a physiologically relevant assay to screen drugs against TB when inside immune cells.
Samantha, Donnellan +3 more
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The human disease tuberculosis (TB) is the leading cause of death from a single infectious agent. A quarter of the world's population is estimated to be latently infected. Drug development and screening is slow and costly. We have developed a physiologically relevant assay to screen drugs against TB when inside immune cells.
Samantha, Donnellan +3 more
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The Journal of Pharmacology and Experimental Therapeutics, 1988
We have developed a 2-week bioassay that quantitates the effect of immunosuppressive drugs on organ allograft rejection. This assay is not only rapid and reliable, but also simple and relatively inexpensive and sparing of test substances. We refined the method by which neonatal mouse hearts are transplanted into pouches in the pinnae of ears of adult ...
G, Babany +3 more
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We have developed a 2-week bioassay that quantitates the effect of immunosuppressive drugs on organ allograft rejection. This assay is not only rapid and reliable, but also simple and relatively inexpensive and sparing of test substances. We refined the method by which neonatal mouse hearts are transplanted into pouches in the pinnae of ears of adult ...
G, Babany +3 more
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