Results 301 to 310 of about 931,718 (350)
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Biometrical journal. Biometrische Zeitschrift, 2018
Successful pharmaceutical drug development requires finding correct doses. The issues that conventional dose‐response analyses consider, namely whether responses are related to doses, which doses have responses differing from a control dose response, the
A. Gould
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Successful pharmaceutical drug development requires finding correct doses. The issues that conventional dose‐response analyses consider, namely whether responses are related to doses, which doses have responses differing from a control dose response, the
A. Gould
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Naunyn-Schmiedeberg's Archives of Pharmacology, 2007
The objective of this study was to characterize the anticonvulsant and acute adverse-effect potentials of topiramate (TPM) and gabapentin (GBP)-two second-generation antiepileptic drugs administered alone and in combination in the maximal electroshock (MES)-induced seizures and chimney test in mice.
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The objective of this study was to characterize the anticonvulsant and acute adverse-effect potentials of topiramate (TPM) and gabapentin (GBP)-two second-generation antiepileptic drugs administered alone and in combination in the maximal electroshock (MES)-induced seizures and chimney test in mice.
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[Timed dose-response relationship analysis of pressor and hypotensive action of drugs].
Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1993The graded and timed dose-response relationship (TDRR) of pressor and hypotensive action by i.v. norepinephrine (NE) and sodium nitroprusside (SNP) respectively were studied in 13 male rabbits. The arterial blood pressure was dose-dependently raised by NE 0.98-125 micrograms.kg-1 and lowered by SNP 7.81-500 micrograms.kg-1 (F test, P < 0.01).
M Y, Wang, J Q, Zheng, B A, Wang
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IEEE/ACM Transactions on Computational Biology & Bioinformatics, 2019
Drug-induced hepatotoxicity may cause acute and chronic liver disease, leading to great concern for patient safety. It is also one of the main reasons for drug withdrawal from the market.
R. Su +4 more
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Drug-induced hepatotoxicity may cause acute and chronic liver disease, leading to great concern for patient safety. It is also one of the main reasons for drug withdrawal from the market.
R. Su +4 more
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[Age as a factor in dose-response relationship of drugs].
Zeitschrift fur Gerontologie und Geriatrie, 1996Drug therapy in the elderly requires careful individualization of the dosage. Whether dose adjustment is due to altered pharmacokinetic or due to altered pharmacodynamic is a matter of experimental evidence which can be found by performing studies with simultaneous measurements of concentration and effect over time.
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Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1997
1. From a review of published literature it is concluded that the minimum dose of a neuroleptic drug (NLD) required to alleviate psychosis is very similar to that producing minimal parkinsonian side effects (PSE). This conclusion is reached both from group comparisons and individual comparisons of dose/response relations (DRR) for the two effects. 2. A
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1. From a review of published literature it is concluded that the minimum dose of a neuroleptic drug (NLD) required to alleviate psychosis is very similar to that producing minimal parkinsonian side effects (PSE). This conclusion is reached both from group comparisons and individual comparisons of dose/response relations (DRR) for the two effects. 2. A
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Toxic Effects of Nonsteroidal Anti-Inflammatory Drugs in Overdose
Drug Safety, 1990Nonsalicylate, nonsteroidal anti-inflammatory drugs (NSAIDs) can be divided into 4 chemical classes: acetic acids, fenamic acids, oxicams and propionic acids. Most NSAID overdoses result in a benign outcome. Of 50,614 exposures reported to poison centres in the United States in a 2-year period, 131 (0.26%) had a major outcome, with 10 deaths.
S C, Smolinske +4 more
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Psychopharmacologia, 1974
Conflict behaviour in a T-maze can be observed at the choice point, involving simultaneous tendencies to move left and right and in the goal box involving simultaneous tendencies to approach the reward and to return towards the choice point. Firstly, the effects of different doses (from 0.06 to 1 mg/kg) of the cholinolytic drug 3-quinuclidinyl ...
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Conflict behaviour in a T-maze can be observed at the choice point, involving simultaneous tendencies to move left and right and in the goal box involving simultaneous tendencies to approach the reward and to return towards the choice point. Firstly, the effects of different doses (from 0.06 to 1 mg/kg) of the cholinolytic drug 3-quinuclidinyl ...
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Effects of drugs on nondiscriminated avoidance behavior
Psychopharmacologia, 1964Thirteen male, Long-Evans rats were trained to press a lever to postpone a brief electric shock. Each rat was subjected to several different doses of chlorpromazine, d-amphetamine, atropine and benactyzine, and then tested for four hours under a mixed schedule of extinction and nondiscriminated avoidance behavior.
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