Results 41 to 50 of about 734,043 (307)

Efikasnost terapijskog monitoringa ciklosporina određivanjem C2 i PIK0−4 tokom prva 24 meseca posle transplantacije bubrega [PDF]

Vojnosanitetski Pregled, 2008
Background/Aim. Cyclosporine (CyA) therapeutic drug monitoring (TDM) through the measurement of drug concentration in blood two hours after the administration (C2), and/or according to the calculated value of the area under the concentration - time curve
Vavić Neven, Ignjatović Ljiljana, Drašković Biljana, Hrvačević Rajko, Kovačević Zoran, Paunić Zoran   +5 more
doaj   +1 more source

Sugammadex ED90 dose to reverse the rocuronium neuromuscular blockade in obese patients

Revista do Colégio Brasileiro de Cirurgiões
Objective: to determine the ED90 (minimum effective dose in 90% of patients) of sugammadex for the reversal of rocuronium-induced moderate neuromuscular blockade (NMB) in patients with grade III obesity undergoing bariatric surgery.
MAURO PRADO DA SILVA, CHRISTIANO MATSUI, DANIEL DONGIOU KIM, JOAQUIM EDSON VIEIRA, CARLOS ALBERTO MALHEIROS, LIGIA ANDRADE SILVA TELLES MATHIAS   +5 more
doaj   +1 more source

Negative Symptoms in Schizophrenia: Exploring Glutamatergic Modulation Using a Computer-Based Quantitative Systems Pharmacology Approach

Frontiers in Pharmacology, 2014
Although many antipsychotics can reasonably control positive symptoms in schizophrenia, patients’ return to society is often hindered by negative symptoms and cognitive deficits.
Hugo eGeerts, Hugo eGeerts, Athan eSpiros, Patrick eRoberts, Patrick eRoberts   +4 more
doaj   +1 more source

Aspects of the Relationship between Drug Dose and Drug Effect

Dose-Response, 2009
It is generally assumed that there exists a well-defined relationship between drug dose and drug effect and that this can be expressed by a dose-response curve.
Abraham Peper
doaj   +1 more source

Two-compartment pharmacokinetic model of itraconazole after single oral dose administration - gender differences [PDF]

Vojnosanitetski Pregled
Background/Aim. Itraconazole (ICZ) is a widely used antifungal drug with hypervariable pharmacokinetics (PK), which is the result of the molecule’s nature itself, as well as the influence of multiple factors.
Miljković Milijana, Kovačević Aleksandra, Mikov Momir, Stanojković Tijana, Dragojević-Simić Viktorija   +4 more
doaj   +1 more source

Giardicidal effect of black tea (camellia sinensis) in the treatment of giardia duodenalis in swiss mice

Revista Contexto & Saúde
This study evaluated the in vivo giardicidal potential of black tea (Camellia sinensis) in male Swiss mice experimentally infected with 104 cysts of Giardia duodenalis assemblage BIV.
Liara Izabela Lopes Romera, Cristiane Maria Colli, Amanda Gubert Alves dos Santos, Gessilda de Alcântara Nogueira de Melo, Ariana Ferrari, Mônica Lúcia Gomes   +5 more
doaj   +1 more source

Comparing Two Different Doses of Intravenous Midazolamin in Pediatric Sedation and Analgesia

Archives of Academic Emergency Medicine, 2018
Introduction: Midazolam has turned into a common drug for pediatric procedural sedation and analgesia. However, there is not much data regarding its proper dose and potential side effects in the Iranian children population.
Hassan Barzegari, Arash Forouzan, Kambiz Masoumi, Hassan Motamed, Behzad Zohrevandi, Shima Zeynadini Meymand   +5 more
doaj   +1 more source

Assessing the similarity of dose response and target doses in two non-overlapping subgroups [PDF]

, 2017
We consider two problems that are attracting increasing attention in clinical dose finding studies. First, we assess the similarity of two non-linear regression models for two non-overlapping subgroups of patients over a restricted covariate space.
Bretz, Frank, Dette, Holger, Liu, Wei, Möllenhoff, Kathrin, Trampisch, Matthias   +4 more
core   +2 more sources

Estimating the turnover time of high intravenous intake of vitamin C [PDF]

Archive of Oncology, 2011
Background: Intravenous dosing is generally recognized to be the only effective means of maintaining a high concentration of vitamin C in the plasma.
Wong Alfred
doaj   +1 more source

Everolimus dosing recommendations for tuberous sclerosis complex–associated refractory seizures [PDF]

, 2018
ObjectiveThe present analysis examined the exposure-response relationship by means of the predose everolimus concentration (C-min) and the seizure response in patients with tuberous sclerosis complex-associated seizures in the EXIST-3 study ...
Brandt, Christian, Cheung, Wing, Coello, Neva, Franz, David N, French, Jacqueline A, Grosch, Kai, Kohrman, Michael H, Lawson, John A, Milh, Mathieu, Voi, Maurizio, Wiemer-Kruel, Adelheid, Wong, Michael, Yapici, Zuhal   +12 more
core   +2 more sources