Results 41 to 50 of about 699,010 (308)

Sugammadex ED90 dose to reverse the rocuronium neuromuscular blockade in obese patients

Revista do Colégio Brasileiro de Cirurgiões
Objective: to determine the ED90 (minimum effective dose in 90% of patients) of sugammadex for the reversal of rocuronium-induced moderate neuromuscular blockade (NMB) in patients with grade III obesity undergoing bariatric surgery.
MAURO PRADO DA SILVA, CHRISTIANO MATSUI, DANIEL DONGIOU KIM, JOAQUIM EDSON VIEIRA, CARLOS ALBERTO MALHEIROS, LIGIA ANDRADE SILVA TELLES MATHIAS   +5 more
doaj   +1 more source

Negative Symptoms in Schizophrenia: Exploring Glutamatergic Modulation Using a Computer-Based Quantitative Systems Pharmacology Approach

Frontiers in Pharmacology, 2014
Although many antipsychotics can reasonably control positive symptoms in schizophrenia, patients’ return to society is often hindered by negative symptoms and cognitive deficits.
Hugo eGeerts, Hugo eGeerts, Athan eSpiros, Patrick eRoberts, Patrick eRoberts   +4 more
doaj   +1 more source

A Phase I Study of Abiraterone Acetate Combined with BEZ235, a Dual PI3K/mTOR Inhibitor, in Metastatic Castration Resistant Prostate Cancer. [PDF]

, 2017
Lessons learnedThe combination of standard dose abiraterone acetate and BEZ235, a pan-class I PI3K and mTORC1/2 inhibitor, was poorly tolerated in men with progressive mCRPC.Although the clinical development of BEZ235 has been discontinued in prostate ...
Friedlander, Terence, Hsieh, Andrew C, Kim, Won, Lin, Amy M, Louttit, Mirela, Ryan, Charles J, Wei, Xiao X   +6 more
core   +1 more source

Aspects of the Relationship between Drug Dose and Drug Effect

Dose-Response, 2009
It is generally assumed that there exists a well-defined relationship between drug dose and drug effect and that this can be expressed by a dose-response curve.
Abraham Peper
doaj   +1 more source

Everolimus dosing recommendations for tuberous sclerosis complex–associated refractory seizures [PDF]

, 2018
ObjectiveThe present analysis examined the exposure-response relationship by means of the predose everolimus concentration (C-min) and the seizure response in patients with tuberous sclerosis complex-associated seizures in the EXIST-3 study ...
Brandt, Christian, Cheung, Wing, Coello, Neva, Franz, David N, French, Jacqueline A, Grosch, Kai, Kohrman, Michael H, Lawson, John A, Milh, Mathieu, Voi, Maurizio, Wiemer-Kruel, Adelheid, Wong, Michael, Yapici, Zuhal   +12 more
core   +2 more sources

Estimating the turnover time of high intravenous intake of vitamin C [PDF]

Archive of Oncology, 2011
Background: Intravenous dosing is generally recognized to be the only effective means of maintaining a high concentration of vitamin C in the plasma.
Wong Alfred
doaj   +1 more source

Population Pharmacokinetic Study of Benznidazole in Pediatric Chagas Disease Suggests Efficacy despite Lower Plasma Concentrations than in Adults [PDF]

, 2014
Introduction:Chagas disease, caused by the parasite Trypanosoma cruzi, can lead to long term cardiac morbidity. Treatment of children with benznidazole is effective, but no pediatric pharmacokinetics data are available and clinical pharmacology ...
Altcheh, Jaime Marcelo, Ballering, Griselda, Bisio, Margarita María Catalina, García Bournissen, Facundo, Giglio, Norberto, Koren, Gideon, Marson, María Elena, Mastrantonio Garrido, Guido Enrique, Moroni, Samanta, Moscatelli, Guillermo   +9 more
core   +5 more sources

Giardicidal effect of black tea (camellia sinensis) in the treatment of giardia duodenalis in swiss mice

Revista Contexto & Saúde
This study evaluated the in vivo giardicidal potential of black tea (Camellia sinensis) in male Swiss mice experimentally infected with 104 cysts of Giardia duodenalis assemblage BIV.
Liara Izabela Lopes Romera, Cristiane Maria Colli, Amanda Gubert Alves dos Santos, Gessilda de Alcântara Nogueira de Melo, Ariana Ferrari, Mônica Lúcia Gomes   +5 more
doaj   +1 more source

Comparing Two Different Doses of Intravenous Midazolamin in Pediatric Sedation and Analgesia

Archives of Academic Emergency Medicine, 2018
Introduction: Midazolam has turned into a common drug for pediatric procedural sedation and analgesia. However, there is not much data regarding its proper dose and potential side effects in the Iranian children population.
Hassan Barzegari, Arash Forouzan, Kambiz Masoumi, Hassan Motamed, Behzad Zohrevandi, Shima Zeynadini Meymand   +5 more
doaj   +1 more source

Dose optimisation and scarce resource allocation: two sides of the same coin

BMJ Open, 2022
Objective A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines.Summary of key data The vast majority of drug development and ...
Govind Persad, Srinivas Murthy, William F Parker, Garth Strohbehn   +3 more
doaj   +1 more source