Results 71 to 80 of about 925,610 (310)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Practical considerations for optimal designs in clinical dose finding studies [PDF]

, 2008
Determining an adequate dose level for a drug and, more broadly, characterizing its dose response relationship, are key objectives in the clinical development of any medicinal drug.
Bretz, Frank, Dette, Holger, Pinheiro, Jose   +2 more
core   +1 more source

Pharmacokinetic/pharmacodynamic modelling approaches in paediatric infectious diseases and immunology. [PDF]

, 2014
Pharmacokinetic/pharmacodynamic (PKPD) modelling is used to describe and quantify dose-concentration-effect relationships. Within paediatric studies in infectious diseases and immunology these methods are often applied to developing guidance on ...
Abdel-Rahman, Ahsman, Ambrose, Anderson, Anderson, Anderson, Andes, Andes, Assael, Baley, Barclay, Barclay, Barlogis, Bartelink, Bayles, Benjamin, Benson, Berger, Bhandari, Blumer, Bomgaars, Bonate, Botha, Bouazza, Bradley, Buck, Burkhardt, Call, Charles, Charlotte I.S. Barker, Charrier, Chen, Clave, Cohen-Wolkowiez, Cohen-Wolkowiez, Committee, Craig, De Beaudrap, de Groot, de Hoog, de Hoog, de Hoog, de Repentigny, Doby, Doogue, Dowell, Downing, Driscoll, Driscoll, Drusano, Drylewicz, Du, Dudley, Duval, Elter, Englund, Ette, Ette, Ette, Eva Germovsek, Fallen, Fedele, Filler, Fletcher, Foot, Forrest, Frenkel, Friberg, Garcia, Garrido, Giannelli, Giuliano, Glowka, Gonzalez-Peralta, Grimsley, Groll, Groll, Guedj, Hassan, Hennig, Herbrecht, Hintz, Hong, Hope, Hope, Hope, Hope, Hosoya, Huenecke, Iida, Ikawa, Izquierdo, Jacqz-Aigrain, Jensen, Joanna Lewis, Jodi M. Lestner, Joseph F. Standing, Kafetzis, Karlsson, Kaufman, Kearns, Kelley, Kicklighter, Kim, Kimberlin, Kimberlin, Kimberlin, Knoderer, Koehl, Koenig, Kohli, Krakovska, Krishna, Lam, Lankester, Lavielle, Lee, Lee, Lestner, Lewis, Lewis, Lewis, Li, Li, Lodise, Louie, Luck, Lukas, Marques-Minana, McJunkin, Meszner, Mohamed, Moore, Muller, Muller, Neely, Neely, Nielsen, Ogungbenro, Ohata, Olkinuora, Oxford, Padari, Palumbo, Parker, Pascual, Payen, Perelson, Pescovitz, Pescovitz, Piper, Plunkett, Prague, Preston, Pullen, Putter, Rajagopalan, Renard, Rodriguez, Rodriguez-Tudela, Rollo L. Hoare, Rong, Rudd, Sabin, Saez-Llorens, Saez-Llorens, Salinger, Sardemann, Saxen, Schaefer, Schmitt, Schwinger, Seibel, Seidel, Sherwin, Smith, Standing, Starke, Sugaya, Sullender, Surh, Suyagh, Tamma, Tarral, Tasso, Tedeschi, Terragna, Thiebaut, Thiébaut R, Tod, Tod, Touw, Tulkens, van den Anker, van Hasselt, Vandecasteele, Vaudry, Vervelde, Vezina, Walsh, Waxman, Willemze, Wu, Wurthwein, Yoshizawa, Zeng, Zhang, Zhao, Zobell   +208 more
core   +1 more source

Predicting Drug-Drug Interactions from Heterogeneous Data: An Embedding Approach [PDF]

arXiv, 2021
Predicting and discovering drug-drug interactions (DDIs) using machine learning has been studied extensively. However, most of the approaches have focused on text data or textual representation of the drug structures. We present the first work that uses multiple data sources such as drug structure images, drug structure string representation and ...
arxiv  

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Episcleral Venous Pressure and the Ocular Hypotensive Effects of Topical and Intracameral Prostaglandin Analogs. [PDF]

, 2019
There is a limit beyond which increasing either the concentration of a prostaglandin analog (PGA) or its dosing frequency fails to produce increases in ocular hypotensive efficacy with topical dosing.
Alm, Blondeau, Brubaker, Celebi, Chen, Cymbor, Eveleth, Foroozan, Friberg, Funk, Funk, Katz, Krieglstein, Lee, Lee, Lee, Lewis, Lindén, Lovering, McDougal, Nagasubramanian, Ogundele, Phelps, Prum, Seal, Selbach, Selbach, Sherwood, Sit, Sit, Strohmaier, Tsai, Walløe, Watts, Wilke, Zamora, Zamora   +36 more
core   +2 more sources

Determination of the minimum effective volume of bupivacaine for ultrasound-guided infraclavicular brachial plexus block: a prospective, observer-blind, controlled study

Brazilian Journal of Anesthesiology, 2022
Background: We aimed to determine the minimum effective volume (MEV) of 0.5% bupivacaine for infraclavicular brachial plexus block. Methods: We assigned patients to volume groups consisting of five consecutive patients.
Semih Başkan, Çağıl Vural, Necati Alper Erdoğmuş, İsmail Aytaç   +3 more
doaj  

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Palbociclib has no clinically relevant effect on the QTc interval in patients with advanced breast cancer. [PDF]

, 2018
The aim of this study was to assess the potential effects of palbociclib in combination with letrozole on QTc. PALOMA-2, a phase 3, randomized, double-blind, placebo-controlled trial, compared palbociclib plus letrozole with placebo plus letrozole in ...
Durairaj, Chandrasekar, Ettl, Johannes, Finn, Richard S, Gauthier, Eric R, Hoffman, Justin T, Huang, Xin, Joy, Anil A, Lu, Dongrui R, Rugo, Hope S, Ruiz-Garcia, Ana, Wang, Diane D, Wilner, Keith D, Zheng, Jenny   +12 more
core   +2 more sources

HeTriNet: Heterogeneous Graph Triplet Attention Network for Drug-Target-Disease Interaction [PDF]

arXiv, 2023
Modeling the interactions between drugs, targets, and diseases is paramount in drug discovery and has significant implications for precision medicine and personalized treatments. Current approaches frequently consider drug-target or drug-disease interactions individually, ignoring the interdependencies among all three entities.
arxiv