Results 71 to 80 of about 440,820 (164)

Exposure/Response vs. Dose/Response Relationships in Drug Development

BMC News and views, 2003
openaire   +1 more source

Pharmaceutical Industry Perspectives on Exposure-Response Confounding in Large Molecule Therapeutics: Results From an IQ Consortium Survey. [PDF]

CPT Pharmacometrics Syst Pharmacol
Salama E, Lamba M, Ait-Oudhia S, Wang E, Semiond D, Li Z, Long T, Suryawanshi S, Arrington L, Gao W, Guan X, Giovinazzo H, Miles D, Turner DC.   +13 more
europepmc   +1 more source

Clinical Impact of Target-Mediated Drug Disposition of Small Molecules with Focus on Early Phase I Study Designs. [PDF]

Clin Pharmacol Ther
Tessaro F, Parrott NJ, Wittwer MB, Stark FS, Olivares-Morales A, Derks M, Sturm S.   +6 more
europepmc   +1 more source

Dose response relationships in the evaluation of the effect of drugs on allergen and histamine induced skin wheals

Journal of Allergy and Clinical Immunology, 1982
M.J. Phillips, R. Thomas, R.J. Davies
openaire   +1 more source

Time-Dependent Bias and Prognostic Confounding in Exposure-Response Analysis of Targeted Therapies: Lessons from Sunitinib in Metastatic Renal Cancer. [PDF]

Clin Pharmacol Ther
Liu H, Friberg LE.
europepmc   +1 more source

Evolutionary Antifragile Therapy Is a Treatment Strategy to Suppress Drug Resistance by Exploiting Dose-Response Convexity. [PDF]

Cancer Res
West J, Desai B, Strobl MAR, Gallaher J, Robertson-Tessi M, Marusyk A, Anderson ARA.   +6 more
europepmc   +1 more source

Model-Informed Drug Development (MIDD) for Analgesics: Review of Applications, Regulatory Integration, and Emerging Directions. [PDF]

J Pain Res
Dahan A, Pergolizzi JV, Niesters M, Olofsen E, Raffa RB.   +4 more
europepmc   +1 more source

Hierarchical Composite Endpoints for Dose Optimization in Early Phase Oncology Trials. [PDF]

Pharm Stat
Wu Y, Guo X, Li R, Le Corre C.
europepmc   +1 more source

Population Pharmacokinetic, Exposure-Response Efficacy and Safety Analyses of Favezelimab in Patients With Solid Tumors. [PDF]

Clin Transl Sci
Gaurav M, Barcomb H, Maxwell KF, Kandala B, Chatterjee MS.   +4 more
europepmc   +1 more source

Successful Translational Prediction of Bedaquiline's Phase 2a Clinical Trial Results against Tuberculosis: The Zebrafish as a New Approach Methodology. [PDF]

Clin Pharmacol Ther
van Lieshout B, Hanuun A, van Hasselt JGC, van Wijk RC.   +3 more
europepmc   +1 more source