Results 171 to 180 of about 263,492 (281)

Treatment strategy in stereotactic radiosurgery for trigeminal neuralgia, essential tremor, and coexisting intracranial tumors: The impact of biologically effective dose on clinical outcome. [PDF]

J Appl Clin Med Phys
Sinha S, Goulenko V, Madhugiri VS, Prasad S, Almeida ND, Shekher R, Podgorsak MB, Plunkett RJ, Prasad D.   +8 more
europepmc   +1 more source

A Dose-response Relationship for the Incidence of Radiation-related Heart Disease

International Journal of Radiation Oncology*Biology*Physics, 2010
McGale, P, Darby, S C, Brønnum, Dorthe Scavenius, Correa, C, Ewertz, M, Gagliardi, G, Gigante, B, Nisbet, A, Taylor, C, Hall, P   +9 more
openaire   +4 more sources

Stereotactic MR-guided online adaptive radiation therapy (SMART) for ultracentral thorax malignancies: Results of a phase 1 trial [PDF]

, 2018
Bradley, Jeffrey D, Contreras, Jessika A, Curcuru, Austen, DeWees, Todd A, Green, Olga L, Henke, Lauren E, Kashani, Rojano, Michalski, Jeff, Mutic, Sasa, Olsen, Jeffrey R, Parikh, Parag J, Roach, Michael C, Robinson, Clifford G   +12 more
core   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Comparison of stereotactic body radiotherapy following transcatheter arterial chemoembolization <i>vs</i> transcatheter arterial chemoembolization alone in hepatocellular carcinoma. [PDF]

World J Gastrointest Surg
Chen L, Wang L, Wang H.
europepmc   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Carbon ion FLASH irradiation reduces acute skin toxicity compared with conventional dose rate irradiation. [PDF]

Sci Rep
Yoshida Y, Suda H, Tashiro M, Yusa K, Nakao M, Ando K, Takahashi A, Ohno T.   +7 more
europepmc   +1 more source

Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

Advanced Science, EarlyView.
This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang, Jie Zhu, Zequn Ding, Zhiyuan Xie, Xingchen Liu, Feihong Zhang, Xiaojun Liu, Yan Zhang, Haiyan Chen   +8 more
wiley   +1 more source

Impact of Low-Dose CT Radiation on Gene Expression and DNA Integrity. [PDF]

Int J Mol Sci
Schmid N, Gorte V, Akers M, Verloh N, Haimerl M, Stroszczynski C, Scherthan H, Orben T, Stewart S, Kubitscheck L, Kaatsch HL, Port M, Abend M, Ostheim P.   +13 more
europepmc   +1 more source

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source