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Radiation dose-response relationships
2018Clinical radiobiology is a field of medical research concerned with the relationship between a given physical absorbed dose of radiation in the range used for cancer therapy and the resulting biological response in a human as well as with the factors that influence this relationship. What is seen in clinical practice is a broad range of doses where the
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Mechanisms and dose-response relationships for radiation-induced cardiovascular disease
Annals of the ICRP, 2012Epidemiological studies have shown a clear association between therapeutic doses of thoracic irradiation and increased risk of cardiovascular disease in long-term cancer survivors. Survivors of Hodgkin's lymphoma and childhood cancers, for example, show 2- to >7-fold increases in risk of cardiac death after total tumour doses of 30–40 Gy, given in ...
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The dose-response relationship for tumourigenesis by UV radiation in the region 311 – 312 nm
Journal of Photochemistry and Photobiology B: Biology, 1988Groups of hairless mice were irradiated daily with Philips TL01 UVB sources. This type of lamp has become available recently and was developed for UVB phototherapy of psoriasis. The TL01 emits radiation in a narrow band around 311-312 nm. Tumours developed on all animals.
H. van Weelden +2 more
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Dose–Response Relationship for Parathyroid Adenoma after Exposure to Ionizing Radiation in Infancy
Radiation Research, 2002Several authors have suggested that there is an excess risk of hyperparathyroidism, adenomas or hyperplasia after exposure to ionizing radiation. There is still, however, some uncertainty about this association, because these diseases are often asymptomatic and escape clinical detection if not specially searched for.
Lars-Erik Holm +4 more
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Environmental and Molecular Mutagenesis, 1994
AbstractMicronuclei were assessed among the bone marrow PCEs of mice 28 hr after exposures to 1 to 8 Gy of X‐rays and at 6‐hr intervals from 12‐60 hr after exposures to 2 or 6 Gy. At 28 hr, the frequency of micronuclei declined as the exposure level increased from 1 to 8 Gy.
Alfred F. McFee +2 more
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AbstractMicronuclei were assessed among the bone marrow PCEs of mice 28 hr after exposures to 1 to 8 Gy of X‐rays and at 6‐hr intervals from 12‐60 hr after exposures to 2 or 6 Gy. At 28 hr, the frequency of micronuclei declined as the exposure level increased from 1 to 8 Gy.
Alfred F. McFee +2 more
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Radiotherapy and Oncology, 1984
One hundred and thirteen patients with advanced locoregional recurrent (77), residual (18) or primarily inoperable (18) colorectal carcinoma were treated with radiotherapy. Eighty-five patients had locoregional disease only and 28 had both local disease and distant metastases.
Overgaard, Marie +2 more
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One hundred and thirteen patients with advanced locoregional recurrent (77), residual (18) or primarily inoperable (18) colorectal carcinoma were treated with radiotherapy. Eighty-five patients had locoregional disease only and 28 had both local disease and distant metastases.
Overgaard, Marie +2 more
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Journal of Photochemistry and Photobiology B: Biology, 2008
Vitamin D deficiency is a major health concern worldwide. Very little is understood regarding its production in the human body by exposure to UV radiation. In particular, we have no means of predicting how much vitamin D (cholecalciferol) will be produced in the skin after exposure to sunlight.
Olds, William J. +3 more
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Vitamin D deficiency is a major health concern worldwide. Very little is understood regarding its production in the human body by exposure to UV radiation. In particular, we have no means of predicting how much vitamin D (cholecalciferol) will be produced in the skin after exposure to sunlight.
Olds, William J. +3 more
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Tests of the Linear, No-threshold Dose-Response Relationship for High-Let Radiation
Health Physics, 1987It is pointed out that induction of lung cancer by exposure to Rn daughters, applied at high doses to miners and at low doses to exposures in homes, provides a very stringent and sensitive test of the linear, no-threshold dose-response relationship for high-LET radiation, because this relationship predicts that a substantial fraction of lung cancer ...
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Radiotherapy and Oncology, 2010
To evaluate dosimetric factors predictive for radiation-induced pneumonitis (RP) after pulmonary stereotactic body radiotherapy (SBRT).A retrospective analysis was performed based on 59 consecutive patients treated with cone-beam CT-based image-guided SBRT for primary NSCLC (n=21) or pulmonary metastases (n=54).
Gerd Mueller +7 more
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To evaluate dosimetric factors predictive for radiation-induced pneumonitis (RP) after pulmonary stereotactic body radiotherapy (SBRT).A retrospective analysis was performed based on 59 consecutive patients treated with cone-beam CT-based image-guided SBRT for primary NSCLC (n=21) or pulmonary metastases (n=54).
Gerd Mueller +7 more
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Radiation Protection Dosimetry, 2009
Using a single colour fluorescence in situ hybridisation technique, dose-responses were derived for a range of chromosomally aberrant cell types and categories of aberrations induced in peripheral blood lymphocytes by alpha-particle radiation and analysed in their first in vitro division.
EJ Tawn, Hubert Thierens
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Using a single colour fluorescence in situ hybridisation technique, dose-responses were derived for a range of chromosomally aberrant cell types and categories of aberrations induced in peripheral blood lymphocytes by alpha-particle radiation and analysed in their first in vitro division.
EJ Tawn, Hubert Thierens
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