Results 151 to 160 of about 1,331,644 (204)
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2009
In general, the effect of a drug can be considered to be proportional to its dose; the documentation of such a relationship is important in early investigations of drug effects; effects with biological substances as e.g. interferons may go through an optimum, i.e. decreasing with increasing doses; → see also phase i.
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In general, the effect of a drug can be considered to be proportional to its dose; the documentation of such a relationship is important in early investigations of drug effects; effects with biological substances as e.g. interferons may go through an optimum, i.e. decreasing with increasing doses; → see also phase i.
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Dose-Response Relationship With Venlafaxine
Journal of Clinical Psychopharmacology, 1996Considerations when selecting a first-line antidepressant agent include the potential for achieving greater response with increasing dosages, thereby allowing greater flexibility in dosing. The efficacy and dose-response of venlafaxine, a novel serotonin and norepinephrine reuptake inhibitor, was evaluated in two placebo-controlled studies.
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Dose-response relationship in skin sensitization
Food and Chemical Toxicology, 1994The dose-response relationship (challenge phase) of the skin sensitization response was investigated in previously sensitized Hartley guinea pigs. Larger numbers of animals were used per group at the lower doses so that statistically significant observations could be made.
R L, Bronaugh, C D, Roberts, J L, McCoy
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Dose-Response Relationship of Phototherapy for Hyperbilirubinemia
Pediatrics, 2012BACKGROUND AND OBJECTIVE: Using light-emitting diodes during conventional phototherapy, it is possible to reduce the distance from light source to infant, thus increasing light irradiance. The objective of this study was to search for a “saturation point” (ie, an irradiation level above which there is no further
Vandborg, Pernille Kure +3 more
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The Dose-Response Relationship of Tranexamic Acid
Anesthesiology, 1995Background Prophylactic administration of the antifibrinolytic drug tranexamic acid decreases bleeding and transfusions after cardiac operations. However, the best dose of tranexamic acid for this purpose remains unknown. This study explored the dose-response relationship of tranexamic acid for hemostatic efficacy after cardiac
J C, Horrow +4 more
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1985
In this chapter, experimental results concerning the quantitative relationship between the atmospheric concentrations of ozone and PAN and effects on higher plants will be described, documented, and evaluated. The goal is to establish the limits of impact by photochemical oxidants on vegetation as a basis for risk prognosis and to pave the way for ...
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In this chapter, experimental results concerning the quantitative relationship between the atmospheric concentrations of ozone and PAN and effects on higher plants will be described, documented, and evaluated. The goal is to establish the limits of impact by photochemical oxidants on vegetation as a basis for risk prognosis and to pave the way for ...
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Dose-response relationships represent the cornerstone of toxicological assessment, quantifying how biological systems react to varying exposure levels of toxic substances. These relationships help determine whether effects follow threshold or non-threshold models, with threshold responses occurring only above specific dose levels while non-threshold ...
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Modeling Dose-Response Relationships
1997Theories of the effects of the environment on health are founded on the axiom that each state of health is reached through a series of changes in the body which may be identified as distinct stages1. A particular health effect, therefore, requires several changes in the cells, tissues or organs of the body, and often requires doses from several ...
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Dose-response relationships with antihypertensive drugs
Pharmacology & Therapeutics, 1992A variety of antihypertensive drugs have been introduced into clinical practice at excessively high dose. Examples include most thiazide diuretics, propranolol, oxprenolol, atenolol, methyldopa, hydralazine and captopril. These very high doses have usually resulted from studies in which doses have been increased at regular intervals until the desired ...
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Dose-response relationship for supraglottic laryngeal carcinoma
International Journal of Radiation Oncology*Biology*Physics, 1983In this editorial, two important issues in the treatment of cancers of the supraglottic larynx which had been raised by other authors, Harwood et al., are discussed. The first is the technique of elective irradiation of clinically uninvolved neck nodes.
L J, Peters, H D, Thames
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